| SUN1 inhibits osteogenesis and promotes adipogenesis of human adipose-derived stem cells by regulating alpha-tubulin and CD36 expression. | SUN1 inhibits osteogenesis and promotes adipogenesis of human adipose-derived stem cells by regulating α-tubulin and CD36 expression.
Fan T, Zhu J, Liu W, Qu R, Khan AU, Shi Y, Liu J, Zhou Z, Xu C, Dai J, Ouyang J., Free PMC Article | 10/10/2024 |
| SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis. | SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
Baskerville V, Rapuri S, Mehlhop E, Coyne AN., Free PMC Article | 01/11/2024 |
| Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans. | Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans.
Meng Q, Shao B, Zhao D, Fu X, Wang J, Li H, Zhou Q, Gao T. | 04/4/2023 |
| Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans. | Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.
Wu H, Zhang X, Hua R, Li Y, Cheng L, Li K, Liu Y, Gao Y, Shen Q, Wang G, Lv M, Xu Y, He X, Cao Y, Liu M. | 10/22/2022 |
| Nuclear restriction of HIV-1 infection by SUN1. | Nuclear restriction of HIV-1 infection by SUN1.
Persaud M, Selyutina A, Buffone C, Opp S, Donahue DA, Schwartz O, Diaz-Griffero F., Free PMC Article | 01/1/2022 |
| The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. | The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
Hieda M, Matsumoto T, Isobe M, Kurono S, Yuka K, Kametaka S, Wang JY, Chi YH, Kameda K, Kimura H, Matsuura N, Matsuura S., Free PMC Article | 12/18/2021 |
| The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure. | The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure.
Satomi E, Ueda M, Katahira J, Hieda M. | 07/3/2021 |
| The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Chen Y, Wang Y, Chen J, Zuo W, Fan Y, Huang S, Liu Y, Chen G, Li Q, Li J, Wu J, Bian Q, Huang C, Lei M., Free PMC Article | 06/12/2021 |
| SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells. | SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
Porter L, Minaisah RM, Ahmed S, Ali S, Norton R, Zhang Q, Ferraro E, Molenaar C, Holt M, Cox S, Fountain S, Shanahan C, Warren D., Free PMC Article | 01/16/2021 |
| Progerin overexpression increased levels of SUN1, which couples the nucleus to microtubules through nesprin-2G and dynein, and microtubule association with the nucleus. Reducing microtubule-nuclear connections through SUN1 depletion or dynein inhibition rescued the polarity defects. | Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.
Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG., Free PMC Article | 05/4/2019 |
| Results provide evidence that SUN1 is involved in mRNA export and this function is regulated by phosphorylation of serine 113 in the N-terminal domain. | The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation.
Li P, Stumpf M, Müller R, Eichinger L, Glöckner G, Noegel AA., Free PMC Article | 04/20/2019 |
| Mechanisms of SUN1 Oligomerization in the Nuclear Envelope | Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope.
Jahed Z, Fadavi D, Vu UT, Asgari E, Luxton GWG, Mofrad MRK., Free PMC Article | 02/23/2019 |
| While Sun1 and Sun2 in HeLa cells are each able to bind KASH-domains, Sun1 is more efficiently incorporated into LINC complexes under normal growth conditions. Furthermore, the balance of Sun1 and Sun2 incorporated into LINC complexes is cell type-specific and is correlated with SRF/Mkl1-dependent gene expression. | Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression.
May CK, Carroll CW., Free PMC Article | 12/22/2018 |
| Low SUN1 expression is associated with HIV infections. | SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A.
Luo X, Yang W, Gao G., Free PMC Article | 08/4/2018 |
| Thus, AID is a conserved functional domain in SUN proteins and this work provides the structural evidence to support the conversation of the AID-mediated autoinhibition of SUN proteins. | Structural conservation of the autoinhibitory domain in SUN proteins.
Xu Y, Li W, Ke H, Feng W. | 03/17/2018 |
| SUN1/SUN2 may function redundantly in early HIV-1 infection steps and therefore influence HIV-1 replication and pathogenesis. | Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.
Schaller T, Bulli L, Pollpeter D, Betancor G, Kutzner J, Apolonia L, Herold N, Burk R, Malim MH., Free PMC Article | 09/30/2017 |
| wndchrm revealed a consistent negative correlation between SUN1 expression and the size of nucleoli in human breast cancer tissues. | Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.
Matsumoto A, Sakamoto C, Matsumori H, Katahira J, Yasuda Y, Yoshidome K, Tsujimoto M, Goldberg IG, Matsuura N, Nakao M, Saitoh N, Hieda M., Free PMC Article | 12/17/2016 |
| Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2, as well as the Sec61 translocon complex. | Nuclear envelope-associated endosomes deliver surface proteins to the nucleus.
Chaumet A, Wright GD, Seet SH, Tham KM, Gounko NV, Bard F., Free PMC Article | 04/30/2016 |
| SUN1 plays a role in hnRNP-involved mRNA export. | Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export.
Li P, Noegel AA., Free PMC Article | 04/2/2016 |
| An important role for SUN1 and SUN2 in muscle disease pathogenesis. | Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.
Meinke P, Mattioli E, Haque F, Antoku S, Columbaro M, Straatman KR, Worman HJ, Gundersen GG, Lattanzi G, Wehnert M, Shackleton S., Free PMC Article | 11/7/2015 |
| these data support a model whereby mitotic phosphorylation of SUN1 disrupts interactions with nucleoplasmic binding partners, promoting disassembly of the nuclear lamina and, potentially, its chromatin interactions | Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact.
Patel JT, Bottrill A, Prosser SL, Jayaraman S, Straatman K, Fry AM, Shackleton S., Free PMC Article | 08/8/2015 |
| The Caenorhabditis elegans lamin, LMN-1, is required for nuclear migration and interacts with the nucleoplasmic domain of the SUN protein UNC-84. | The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration.
Bone CR, Tapley EC, Gorjánácz M, Starr DA., Free PMC Article | 06/6/2015 |
| Results highlight the interactions at the nuclear envelope where mutations in the EMD and TMPO gene in combination with mutations in SUN1 have an impact on several components of the network. | Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies.
Li P, Meinke P, Huong le TT, Wehnert M, Noegel AA. | 01/31/2015 |
| Farnesylation of progerin enhances its interaction with SUN1 and reduces SUN1 mobility. | Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies.
Chen ZJ, Wang WP, Chen YC, Wang JY, Lin WH, Tai LA, Liou GG, Yang CS, Chi YH. | 12/6/2014 |
| Codepletion of SUN1/2 slows cell proliferation and results in an accumulation of morphologically defective and disoriented mitotic spindles. | SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown.
Turgay Y, Champion L, Balazs C, Held M, Toso A, Gerlich DW, Meraldi P, Kutay U., Free PMC Article | 05/24/2014 |