| USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2. | USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2.
Zhou N, Guo C, Li X, Tu L, Du J, Qian Q, Li J, Huang D, Xu Q, Zheng X. | 11/4/2024 |
| MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24. | MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
Hu Z, Zhao Y, Mang Y, Zhu J, Yu L, Li L, Ran J. | 06/1/2023 |
| USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway. | USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
He H, Yi L, Zhang B, Yan B, Xiao M, Ren J, Zi D, Zhu L, Zhong Z, Zhao X, Jin X, Xiong W., Free PMC Article | 03/19/2022 |
| USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. | USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Bedekovics T, Hussain S, Zhang Y, Ali A, Jeon YJ, Galardy PJ. | 05/22/2021 |
| USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy. | USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
Wang SA, Young MJ, Jeng WY, Liu CY, Hung JJ., Free PMC Article | 03/13/2021 |
| The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability. | The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM., Free PMC Article | 11/28/2020 |
| Data indicate that ubiquitin specific peptidase 24 (USP24) promotes Interleukin-6 (IL-6) expression, which might be beneficial for cancer therapy. | USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.
Wang YC, Wu YS, Hung CY, Wang SA, Young MJ, Hsu TI, Hung JJ., Free PMC Article | 01/12/2019 |
| USP24 level was decreased during the early stage of cancer and the mitotic stage of the cell cycle to regulate its substrates p300, Bax, E2F4 and securin, resulting in decreased cell apoptosis and increased cell cycle progression and, thus, cancer formation. | EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.
Wang SA, Wang YC, Chuang YP, Huang YH, Su WC, Chang WC, Hung JJ., Free PMC Article | 09/23/2017 |
| Data show that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples. | Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.
Wang YC, Wang SA, Chen PH, Hsu TI, Yang WB, Chuang YP, Su WC, Liaw HJ, Chang WC, Hung JJ. | 09/16/2017 |
| USP24 deubiquitinase regulates the DNA damage response by directly targeting the p53 tumor suppressor. | The deubiquitinating enzyme USP24 is a regulator of the UV damage response.
Zhang L, Nemzow L, Chen H, Lubin A, Rong X, Sun Z, Harris TK, Gong F., Free PMC Article | 09/26/2015 |
| the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice. | Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.
Peterson LF, Sun H, Liu Y, Potu H, Kandarpa M, Ermann M, Courtney SM, Young M, Showalter HD, Sun D, Jakubowiak A, Malek SN, Talpaz M, Donato NJ. | 08/15/2015 |
| These results suggested that USP24 expression is tightly regulated at its transcription level and NFkappaB plays an important role in this process. | Transcriptional regulation of human USP24 gene expression by NF-kappa B.
Wang K, Liu S, Wang J, Wu Y, Cai F, Song W. | 05/17/2014 |
| The knockdown of USP24 in two human cell lines decreased the steady-state levels of DDB2, indicating that USP24-mediated DDB2 deubiquitination prevents DDB2 degradation. | The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.
Zhang L, Lubin A, Chen H, Sun Z, Gong F., Free PMC Article | 05/18/2013 |
| The present study is the first to report a lack of association between SNPs of USP24 and parkinson disease in Han Chinese patients. Other | Association analysis of single-nucleotide polymorphisms of USP24 and USP40 with Parkinson's disease in the Han Chinese population.
Zhao B, Song W, Chen YP, Huang R, Chen K, Cao B, Yang Y, Shang HF. | 03/9/2013 |
| USP24 alone plays a role in PD susceptibility among Taiwanese people >or=60 years of age, or acting synergistically with USP40 and UCHL1 in the total subjects. | Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
Wu YR, Chen CM, Chen YC, Chao CY, Ro LS, Fung HC, Hsiao YC, Hu FJ, Lee-Chen GJ, Wu YR, Chen CM, Chen YC, Chao CY, Ro LS, Fung HC, Hsiao YC, Hu FJ, Lee-Chen GJ. | 09/6/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
Wu YR, Chen CM, Chen YC, Chao CY, Ro LS, Fung HC, Hsiao YC, Hu FJ, Lee-Chen GJ, Wu YR, Chen CM, Chen YC, Chao CY, Ro LS, Fung HC, Hsiao YC, Hu FJ, Lee-Chen GJ. | 04/7/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.
Li Y, Schrodi S, Rowland C, Tacey K, Catanese J, Grupe A, Li Y, Schrodi S, Rowland C, Tacey K, Catanese J, Grupe A. | 03/13/2008 |
| Data suggest that genetic variants in USP24 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology. | Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.
Li Y, Schrodi S, Rowland C, Tacey K, Catanese J, Grupe A, Li Y, Schrodi S, Rowland C, Tacey K, Catanese J, Grupe A. | 01/21/2010 |