| RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p. | RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.
Bai T, Liu N. | 04/6/2023 |
| Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome. | Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.
Enwerem III, Elrod ND, Chang CT, Lin A, Ji P, Bohn JA, Levdansky Y, Wagner EJ, Valkov E, Goldstrohm AC., Free PMC Article | 04/24/2021 |
| Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model. | Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.
Smialek MJ, Ilaslan E, Sajek MP, Swiercz A, Janecki DM, Kusz-Zamelczyk K, Wozniak T, Kotecki M, Handschuh L, Figlerowicz M, Jaruzelska J., Free PMC Article | 03/6/2021 |
| CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging. | CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.
Zhang T, Zhang P, Li HX., Free PMC Article | 02/27/2021 |
| RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs. | RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.
Lee MH, Wu X, Zhu Y., Free PMC Article | 02/6/2021 |
| Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis. | Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.
Wolfe MB, Schagat TL, Paulsen MT, Magnuson B, Ljungman M, Park D, Zhang C, Campbell ZT, Goldstrohm AC, Freddolino PL., Free PMC Article | 01/23/2021 |
| LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2. | LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2.
Duan W, Nian L, Qiao J, Liu NN. | 10/31/2020 |
| The results suggest that PUM1-2 affects the expression of pluripotency genes as well as the efficiency of the cardiac differentiation process. | Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.
Silva ILZ, Robert AW, Cabo GC, Spangenberg L, Stimamiglio MA, Dallagiovanna B, Gradia DF, Shigunov P., Free PMC Article | 09/12/2020 |
| circ_0075932 directly bound with the RNA-binding protein PUM2, which was reported to positively regulated AuroraA kinase, thus activating the NF-kappaB pathway. Moreover, either silencing PUM2, silencing AuroraA, or blockade of NF-kappaB activation, could abrogate the promoting effect of adipocyte-derived exosomal circ_0075932 on cell inflammation and apoptosis. | Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway.
Zhang X, Chen L, Xiao B, Liu H, Su Y. | 01/25/2020 |
| A transcriptome-wide approach was used to determine the binding profiles and inter-dependencies of Argonaute2 (AGO2), Pumilio (PUM1 and PUM2) sites on mRNA 3' untranslated regions (3'UTRs). | Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.
Sternburg EL, Estep JA, Nguyen DK, Li Y, Karginov FV., Free PMC Article | 11/2/2019 |
| We have used the RNA-MaP platform to directly measure equilibrium binding for thousands of designed RNAs and to construct a predictive model for RNA recognition by the human Pumilio proteins PUM1 and PUM2. | A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.
Jarmoskaite I, Denny SK, Vaidyanathan PP, Becker WR, Andreasson JOL, Layton CJ, Kappel K, Shivashankar V, Sreenivasan R, Das R, Greenleaf WJ, Herschlag D., Free PMC Article | 10/26/2019 |
| PUM2 could facilitate the stemness of breast cancer cells by competitively binding to NRP-1 3'UTR with miR-376a. | RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.
Zhang L, Chen Y, Li C, Liu J, Ren H, Li L, Zheng X, Wang H, Han Z. | 08/31/2019 |
| PUM2 promote glioblastoma development via repressing BTG1 expression | PUM2 Promotes Glioblastoma Cell Proliferation and Migration via Repressing BTG1 Expression.
Wang Y, Sun W, Yang J, Yang L, Li C, Liu H, Liu X, Jiao B. | 08/3/2019 |
| Data indicate that RNAs-including mRNAs and non-coding RNAs-that are functionally regulated by Pumilio proteins, PUM1 and PUM2. | Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.
Bohn JA, Van Etten JL, Schagat TL, Bowman BM, McEachin RC, Freddolino PL, Goldstrohm AC., Free PMC Article | 07/13/2019 |
| A PUM2-mediated layer of post-transcriptional regulation links altered Mff translation to mitochondrial dynamics and mitophagy, thereby mediating age-related mitochondrial dysfunctions. | The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J., Free PMC Article | 06/29/2019 |
| PUM2 protein cooperativity mediated by RNA structure has been reported. | Demonstration of protein cooperativity mediated by RNA structure using the human protein PUM2.
Becker WR, Jarmoskaite I, Vaidyanathan PP, Greenleaf WJ, Herschlag D., Free PMC Article | 06/15/2019 |
| Using the novel PUM1 and PUM2 mRNA target SIAH1 as a model, this study shows mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1. | PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.
Sajek M, Janecki DM, Smialek MJ, Ginter-Matuszewska B, Spik A, Oczkowski S, Ilaslan E, Kusz-Zamelczyk K, Kotecki M, Blazewicz J, Jaruzelska J., Free PMC Article | 01/26/2019 |
| PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3'UTR with miRNAs | RNA-binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3'UTR with miRNAs.
Hu R, Zhu X, Chen C, Xu R, Li Y, Xu W., Free PMC Article | 12/22/2018 |
| SAM68 is required for efficient recruitment of PUM2 to NORAD, regulation of Pum activity by NORAD, and proper chromosome segregation in mammalian cells. | SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA.
Tichon A, Perry RB, Stojic L, Ulitsky I., Free PMC Article | 06/9/2018 |
| A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1. | NORAD: Defender of the Genome.
Ventura A. | 11/4/2017 |
| results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth. | PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.
Naudin C, Hattabi A, Michelet F, Miri-Nezhad A, Benyoucef A, Pflumio F, Guillonneau F, Fichelson S, Vigon I, Dusanter-Fourt I, Lauret E., Free PMC Article | 09/2/2017 |
| The study shows that pseudouridine and N(6)-methyladenosine weaken the binding of the human single-stranded RNA binding protein Pumilio 2 (hPUM2) to its consensus motif. | Pseudouridine and N(6)-methyladenosine modifications weaken PUF protein/RNA interactions.
Vaidyanathan PP, AlSadhan I, Merriman DK, Al-Hashimi HM, Herschlag D., Free PMC Article | 06/10/2017 |
| Pumilios (including PUM1 and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW] | Bespoke RNA recognition by Pumilios.
Edwards TA. | 08/27/2016 |
| Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability. | Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.
Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT., Free PMC Article | 06/4/2016 |
| PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation. | PUMILIO-2 is involved in the positive regulation of cellular proliferation in human adipose-derived stem cells.
Shigunov P, Sotelo-Silveira J, Kuligovski C, de Aguiar AM, Rebelatto CK, Moutinho JA, Brofman PS, Krieger MA, Goldenberg S, Munroe D, Correa A, Dallagiovanna B., Free PMC Article | 06/23/2012 |