| Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. | Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Jeong A, Cheng S, Zhong R, Bennett DA, Bergö MO, Li L., Free PMC Article | 01/29/2022 |
| Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells. | Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
Klimpel A, Stillger K, Wiederstein JL, Krüger M, Neundorf I. | 07/24/2021 |
| Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. | Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR., Free PMC Article | 02/6/2021 |
| These findings collectively suggest that the combination of farnesyltransferase inhibitors and gamma-secretase inhibitors is a promising therapeutic strategy for glioblastoma through selectively targeting the cancer stem cell subpopulation. | Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.
Ma Y, Cheng Z, Liu J, Torre-Healy L, Lathia JD, Nakano I, Guo Y, Thompson RC, Freeman ML, Wang J., Free PMC Article | 07/21/2018 |
| Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit | Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.
Hagemann A, Müller G, Manthey I, Bachmann HS. | 11/25/2017 |
| our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability | Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ. | 03/31/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB. | 06/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.
Fontaine-Bisson B, Alessi MC, Saut N, Fumeron F, Marre M, Dutour A, Badens C, Levy N, Tichet J, Juhan-Vague I, Trégouët DA, Balkau B, Morange PE. | 12/2/2009 |
| FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity | The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
Zhou J, Vos CC, Gjyrezi A, Yoshida M, Khuri FR, Tamanoi F, Giannakakou P., Free PMC Article | 01/21/2010 |
| Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site. | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Reid TS, Terry KL, Casey PJ, Beese LS. | 01/21/2010 |
| Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. | Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.
Veluthakal R, Kaur H, Goalstone M, Kowluru A. | 01/21/2010 |