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    SIRT1 sirtuin 1 [ Homo sapiens (human) ]

    Gene ID: 23411, updated on 20-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma.

    Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma.
    Yang X, Li S, Xu C, Liu S, Zhang X, Lian B, Li M., Free PMC Article

    06/20/2024
    SIRT1 as a potential therapeutic target in pelvic organ prolapse due to protective effects against oxidative stress and cellular senescence in human uterosacral ligament fibroblasts.

    SIRT1 as a potential therapeutic target in pelvic organ prolapse due to protective effects against oxidative stress and cellular senescence in human uterosacral ligament fibroblasts.
    Wang X, Zhang W, Zhou Y, Li Y, Xu X, Xue J, Ma Y, Liu P.

    06/13/2024
    Sirtuin 1 overexpression contributes to the expansion of follicular helper T cells in systemic lupus erythematosus and may serve as an accessible therapeutic target.

    Sirtuin 1 overexpression contributes to the expansion of follicular helper T cells in systemic lupus erythematosus and may serve as an accessible therapeutic target.
    He L, Liao W, Wang X, Wang L, Liang Q, Jiang L, Yi W, Luo S, Liu Y, Qiu X, Li Y, Liu J, Wu H, Zhao M, Long H, Lu Q.

    06/11/2024
    Analysis of SIRT1 Gene SNPs and Clinical Characteristics in Medication-Related Osteonecrosis of the Jaw.

    Analysis of SIRT1 Gene SNPs and Clinical Characteristics in Medication-Related Osteonecrosis of the Jaw.
    Bojtor B, Vaszilko M, Armos R, Tobias B, Podani J, Szentpeteri S, Balla B, Lengyel B, Piko H, Illes A, Kiss A, Putz Z, Takacs I, Kosa JP, Lakatos P., Free PMC Article

    05/21/2024
    Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages.

    Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages.
    Zheng S, Bulut GB, Kummarapurugu AB, Ma J, Voynow JA., Free PMC Article

    05/17/2024
    SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor beta.

    SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor β.
    Parija M, Prakash S, Krishna BM, Dash S, Mishra SK.

    05/2/2024
    A MiR181/Sirtuin1 regulatory circuit modulates drug response in biliary cancers.

    A MiR181/Sirtuin1 regulatory circuit modulates drug response in biliary cancers.
    Barbato A, Piscopo F, Salati M, Pollastro C, Evangelista L, Ferrante L, Limongello D, Brillante S, Iuliano A, Reggiani-Bonetti L, Salatiello M, Iaccarino A, Pisapia P, Malapelle U, Troncone G, Indrieri A, Dominici M, Franco B, Carotenuto P., Free PMC Article

    04/24/2024
    Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.

    Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.
    Zhou XN, Zhang Q, Peng H, Qin YJ, Liu YH, Wang L, Cheng ML, Luo XH, Li H., Free PMC Article

    04/18/2024
    Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.

    Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.
    Liao MC, Lo CS, Pang YC, Yang WX, Su K, Zhao XP, Miyata KN, Peng J, Ingelfinger JR, Chan JSD, Zhang SL.

    04/16/2024
    Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.

    Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
    Wang Y, Wang S, Wang Y, Wang C, Tang Y, Zhang C, Hou S, Yu D, Lin N.

    04/12/2024
    SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity.

    SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity.
    Kang JA, Kim YJ, Jang KY, Moon HW, Lee H, Lee S, Song HK, Cho SW, Yoo YS, Han HG, Kim MJ, Chung MJ, Choi CY, Lee C, Chung C, Hur GM, Kim YS, Jeon YJ., Free PMC Article

    04/5/2024
    The role and regulation of SIRT1 in pulmonary fibrosis.

    The role and regulation of SIRT1 in pulmonary fibrosis.
    Ma X, Jiang M, Ji W, Yu M, Tang C, Tian K, Gao Z, Su L, Tang J, Zhao X.

    04/3/2024
    Effect of SIRT1 gene single-nucleotide polymorphisms on susceptibility to type 1 diabetes in a Han Chinese population.

    Effect of SIRT1 gene single-nucleotide polymorphisms on susceptibility to type 1 diabetes in a Han Chinese population.
    Li J, Yang Y, Xia Y, Luo S, Lin J, Xiao Y, Li X, Huang G, Yang L, Xie Z, Zhou Z., Free PMC Article

    04/1/2024
    Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.

    Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.
    Krzysiak TC, Choi YJ, Kim YJ, Yang Y, DeHaven C, Thompson L, Ponticelli R, Mermigos MM, Thomas L, Marquez A, Sipula I, Kemper JK, Jurczak M, Thomas G, Gronenborn AM.,

    03/29/2024
    Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism.

    Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism.
    Liao Z, Cai X, Zheng Y, Lin J, Yang X, Lin W, Zhang Y, He X, Liu C.

    03/29/2024
    The mechanism by which SIRT1 regulates autophagy and EMT in drug-resistant oesophageal cancer cells.

    The mechanism by which SIRT1 regulates autophagy and EMT in drug-resistant oesophageal cancer cells.
    Zhang X, Dong Y, Li W, He M, Shi Y, Han S, Li L, Zhao J, Li L, Huo J, Liu X, Ji Y, Liu Q, Wang C.

    03/20/2024
    Expression and correlation of the NOD-like receptor family, pyrin domain-containing 3 inflammasome and the silent information regulator 1 in patients with drug-resistant epilepsy.

    Expression and correlation of the NOD-like receptor family, pyrin domain-containing 3 inflammasome and the silent information regulator 1 in patients with drug-resistant epilepsy.
    Li Q, Qu Z, Jia L, Wang W.

    03/19/2024
    Inhibition of glycolysis and SIRT1/GLUT1 signaling ameliorates the apoptotic effect of Leptosidin in prostate cancer cells.

    Inhibition of glycolysis and SIRT1/GLUT1 signaling ameliorates the apoptotic effect of Leptosidin in prostate cancer cells.
    Park Y, Lee HJ, Sim DY, Park JE, Ahn CH, Park SY, Lee YC, Shim BS, Kim B, Kim SH.

    03/15/2024
    Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism.

    Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism.
    Wang J, Yang Y, Xu Y, Xu Z, Zhao X, Jia R, Dai Y.

    03/1/2024
    Identification of the SIRT1 gene's most harmful non-synonymous SNPs and their effects on functional and structural features-an in silico analysis.

    Identification of the SIRT1 gene's most harmful non-synonymous SNPs and their effects on functional and structural features-an in silico analysis.
    Thayyil Menambath D, Adiga U, Rai T, Adiga S, Shetty V., Free PMC Article

    03/1/2024
    Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity.

    Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity.
    Jung M, Jung JS, Pfeifer J, Hartmann C, Ehrhardt T, Abid CL, Kintzel J, Puls A, Navarrete Santos A, Hollemann T, Riemann D, Rujescu D., Free PMC Article

    02/28/2024
    Alzheimer's Amyloid-beta Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells.

    Alzheimer's Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells.
    Li R, Li Y, Zuo H, Pei G, Huang S, Hou Y., Free PMC Article

    02/28/2024
    Metformin inhibits high glucose-induced apoptosis of renal podocyte through regulating miR-34a/SIRT1 axis.

    Metformin inhibits high glucose-induced apoptosis of renal podocyte through regulating miR-34a/SIRT1 axis.
    Zhuang X, Sun Z, Du H, Zhou T, Zou J, Fu W., Free PMC Article

    02/27/2024
    SIRT1 and miR-34a-5p Expression in PBMCs as Potential Biomarkers for Patients With Type 2 Diabetes With Cognitive Impairments.

    SIRT1 and miR-34a-5p Expression in PBMCs as Potential Biomarkers for Patients With Type 2 Diabetes With Cognitive Impairments.
    Liu X, Zhao Z, Chen D, Zhang Z, Lin X, Shen Z, Lin Q, Fan K, Wang Q, Zhang W, Ou Q.

    02/22/2024
    Up-regulation of TNF-alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma.

    Up-regulation of TNF-alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma.
    de Castro LR, de Oliveira LD, Milan TM, Eskenazi APE, Bighetti-Trevisan RL, de Almeida OGG, Amorim MLM, Squarize CH, Castilho RM, de Almeida LO.

    02/16/2024
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