| Conformational diversity of human HP1alpha. | Conformational diversity of human HP1α.
Ukmar-Godec T, Yu T, de Opakua AI, Pantoja CF, Munari F, Zweckstetter M., Free PMC Article | 07/8/2024 |
| The local density of H3K9me3 dictates the stability of HP1alpha condensates-mediated genomic interactions. | The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions.
Feng Y, Guo L, Yang C, Zheng H, Xiao X, Ma H. | 06/11/2024 |
| Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic target for HP1alpha-positive intrahepatic cholangiocarcinoma. | Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.
Xiong F, Wang D, Xiong W, Wang X, Huang WH, Wu GH, Liu WZ, Wang Q, Chen JS, Kuai YY, Wang B, Chen YJ., Free PMC Article | 06/6/2024 |
| Bipartite binding interface recruiting HP1 to chromosomal passenger complex at inner centromeres. | Bipartite binding interface recruiting HP1 to chromosomal passenger complex at inner centromeres.
Sako K, Furukawa A, Nozawa RS, Kurita JI, Nishimura Y, Hirota T., Free PMC Article | 05/24/2024 |
| How to evict HP1 from H3: Using a complex salt bridge. | How to evict HP1 from H3: Using a complex salt bridge.
Papamokos GV, Kaxiras E. | 08/9/2023 |
| HP1alpha promotes the progression of prostate cancer. | HP1α promotes the progression of prostate cancer.
Zhang S, Li H, Shen C, Cao F, Kang S. | 05/18/2023 |
| Molecular interactions underlying the phase separation of HP1alpha: role of phosphorylation, ligand and nucleic acid binding. | Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding.
Her C, Phan TM, Jovic N, Kapoor U, Ackermann BE, Rizuan A, Kim YC, Mittal J, Debelouchina GT., Free PMC Article | 01/14/2023 |
| Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression. | Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression.
Shi X, Song S, Gao Y, Cui Z, Wang W, Liu M. | 05/21/2022 |
| Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. | Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.
Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, Gourkanti S, Chou T, Barin E, Velleca A, Rohwetter T, Chow A, Taggart J, Savino AM, Hoskova K, Dhodapkar M, Schurer A, Barlowe TS, Vu LP, Leslie C, Steidl U, Rabadan R, Kharas MG., Free PMC Article | 04/23/2022 |
| HP1 proteins compact DNA into mechanically and positionally stable phase separated domains. | HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.
Keenen MM, Brown D, Brennan LD, Renger R, Khoo H, Carlson CR, Huang B, Grill SW, Narlikar GJ, Redding S., Free PMC Article | 01/29/2022 |
| Changes in the properties of membrane tethers in response to HP1alpha depletion in MCF7 cells. | Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells.
Pradhan S, Williams MAK, Hale TK. | 01/15/2022 |
| HP1alpha is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics. | HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics.
Strom AR, Biggs RJ, Banigan EJ, Wang X, Chiu K, Herman C, Collado J, Yue F, Ritland Politz JC, Tait LJ, Scalzo D, Telling A, Groudine M, Brangwynne CP, Marko JF, Stephens AD., Free PMC Article | 12/4/2021 |
| Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy. | Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy.
Suetake I, Nakazawa S, Sato K, Mutoh R, Mishima Y, Kawakami T, Takei T, Watanabe M, Sakai N, Fujiwara T, Takui T, Miyata M, Shinohara A, Hojo H, Arata T. | 11/22/2021 |
| Depletion of HP1alpha alters the mechanical properties of MCF7 nuclei. | Depletion of HP1α alters the mechanical properties of MCF7 nuclei.
Pradhan S, Solomon R, Gangotra A, Yakubov GE, Willmott GR, Whitby CP, Hale TK, Williams MAK., Free PMC Article | 07/31/2021 |
| Physical modeling of the heritability and maintenance of epigenetic modifications. | Physical modeling of the heritability and maintenance of epigenetic modifications.
Sandholtz SH, MacPherson Q, Spakowitz AJ., Free PMC Article | 10/24/2020 |
| HP1s modulate the S-Adenosyl Methionine synthesis pathway in liver cancer cells. | HP1s modulate the S-Adenosyl Methionine synthesis pathway in liver cancer cells.
Mancini M, Papon L, Mangé A, Cammas F, Fabbrizio E. | 10/24/2020 |
| CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. | CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.
Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ., Free PMC Article | 09/19/2020 |
| This study demonstrates that phosphorylation of the HP1alpha linker likely regulates its association with importin subunit alpha-1, which has implications for HP1alpha access to the nucleus, where it functions. | Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.
Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R., Free PMC Article | 07/11/2020 |
| Aurora kinase B S92-phosphorylated HP1alpha is generated in cells at early prophase, localizes to centromeres, and associates with regulators of chromosome stability | Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.
Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA., Free PMC Article | 07/4/2020 |
| show that TBX2 interacts with HP1 through a conserved HP1-binding motif in its N-terminus, which in turn leads to the recruitment of KAP1 and other associated proteins | TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells.
Crawford NT, McIntyre AJ, McCormick A, D'Costa ZC, Buckley NE, Mullan PB., Free PMC Article | 02/15/2020 |
| TLR4 enhances the telomerase activity by reducing the interplay between telomerase reverse transcriptase catalytic subunit (TERT) and TERRA. More importantly, our results reveal that tri-complexes of HP1 isoformsare required for the oncogenic action of TLR4. | Inflammatory factor receptor Toll-like receptor 4 controls telomeres through heterochromatin protein 1 isoforms in liver cancer stem cell.
Zheng Q, Xu J, Lin Z, Lu Y, Xin X, Li X, Yang Y, Meng Q, Wang C, Xiong W, Lu D., Free PMC Article | 11/30/2019 |
| LRIF1 interacts directly with HP1 alpha chromoshadow domain via an evolutionarily conserved PXVXL motif within its C-terminus. Importantly, the LRIF1-HP1 alpha interaction is critical for Aurora B activity in the inner centromere. | LRIF1 interacts with HP1α to coordinate accurate chromosome segregation during mitosis.
Akram S, Yang F, Li J, Adams G, Liu Y, Zhuang X, Chu L, Liu X, Emmett N, Thompson W, Mullen M, Muthusamy S, Wang W, Mo F, Liu X., Free PMC Article | 09/21/2019 |
| The ability of the heterochromatin protein-1 (HP1) to phase separate into droplets suggests new mechanisms of gene organization in the cell nucleus. This study describes procedures for imaging HP1 droplets by brightfield microscopy, and two methods to quantify phase separation. | Visualization and Quantitation of Phase-Separated Droplet Formation by Human HP1α.
Keenen MM, Larson AG, Narlikar GJ., Free PMC Article | 07/27/2019 |
| Mechanistically, mH2A1.2 directly interacts with HP1alpha and H1.2 and requires them to inactivate LTbeta gene in prostate cancer cells. | MacroH2A1.2 inhibits prostate cancer-induced osteoclastogenesis through cooperation with HP1α and H1.2.
Kim JM, Shin Y, Lee S, Kim MY, Punj V, Shin HI, Kim K, Koh JM, Jeong D, An W., Free PMC Article | 07/6/2019 |
| The observations indicate a novel mechanism underlying Neuroendocrine prostate cancer development mediated by abnormally expressed heterochromatin genes, with HP1alpha as an early functional mediator and a potential therapeutic target for Neuroendocrine prostate cancer prevention and management. | Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer.
Ci X, Hao J, Dong X, Choi SY, Xue H, Wu R, Qu S, Gout PW, Zhang F, Haegert AM, Fazli L, Crea F, Ong CJ, Zoubeidi A, He HH, Gleave ME, Collins CC, Lin D, Wang Y. | 06/15/2019 |