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    SEC61G SEC61 translocon subunit gamma [ Homo sapiens (human) ]

    Gene ID: 23480, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis.

    Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis.
    Yuan S, Liu J, Yang L, Zhang X, Zhuang K, He S.

    09/4/2024
    SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.

    SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.
    Fan Y, Wang Y, Liu F, Wang H, Li Q., Free PMC Article

    10/1/2022
    SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.

    SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.
    Shi Y, Liang Y, Wang W, Zhang G., Free PMC Article

    03/26/2022
    SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.

    SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.
    Lu T, Chen Y, Gong X, Guo Q, Lin C, Luo Q, Tu Z, Pan J, Li J., Free PMC Article

    03/19/2022
    Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.

    Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
    Zheng Q, Wang Z, Zhang M, Yu Y, Chen R, Lu T, Liu L, Ma J, Liu T, Zheng H, Li H, Li J., Free PMC Article

    02/19/2022
    SEC61G plays an oncogenic role in hepatocellular carcinoma cells.

    SEC61G plays an oncogenic role in hepatocellular carcinoma cells.
    Gao H, Niu W, He Z, Gao C, Peng C, Niu J., Free PMC Article

    11/27/2021
    SEC61G is upregulated and required for tumor progression in human kidney cancer.

    SEC61G is upregulated and required for tumor progression in human kidney cancer.
    Meng H, Jiang X, Wang J, Sang Z, Guo L, Yin G, Wang Y., Free PMC Article

    10/23/2021
    SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.

    SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
    Ma J, He Z, Zhang H, Zhang W, Gao S, Ni X., Free PMC Article

    10/9/2021
    LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G.

    LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G.
    Han B.

    11/21/2020
    High expression of SEC61G was significantly correlated with poor prognosis in all GBM patients. High expression of SEC61G was also associated with poor outcome.

    Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma.
    Liu B, Liu J, Liao Y, Jin C, Zhang Z, Zhao J, Liu K, Huang H, Cao H, Cheng Q., Free PMC Article

    12/7/2019
    Sequencing of childhood ependymoma samples indicate Sec61 gamma subunit protein (SEC61G)-epidermal growth factor receptor (EGFR) chimeric mRNAs in one infratentorial ependymoma , arguing that this fusion occurs in a small proportion of these tumors.

    Novel SEC61G-EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens.
    Servidei T, Meco D, Muto V, Bruselles A, Ciolfi A, Trivieri N, Lucchini M, Morosetti R, Mirabella M, Martini M, Caldarelli M, Lasorella A, Tartaglia M, Riccardi R.

    11/25/2017
    Cotransin, a substrate-selective Sec61 inhibitor, traps nascent transmembrane domains in the cytosolic vestibule, permitting detailed interrogation of an early pre-integration intermediate.

    An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
    Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J., Free PMC Article

    11/28/2015
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