| Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced Dysfunction Through Upregulating SUZ12 Expression to Activate Wnt/beta-catenin Signaling Pathway. | Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced Dysfunction Through Upregulating SUZ12 Expression to Activate Wnt/β-catenin Signaling Pathway.
Li L, Li C, Cao S, Zhou G, Jiang Y, Feng J. | 12/4/2023 |
| An investigation of the etiology and follow-up findings in 35 children with overgrowth syndromes, including biallelic SUZ12 variant. | An investigation of the etiology and follow-up findings in 35 children with overgrowth syndromes, including biallelic SUZ12 variant.
Yüksel Ülker A, Uludağ Alkaya D, Çağlayan AO, Usluer E, Aykut A, Aslanger A, Vural M, Tüysüz B. | 05/15/2023 |
| Imagawa-Matsumoto syndrome: SUZ12-related overgrowth disorder. | Imagawa-Matsumoto syndrome: SUZ12-related overgrowth disorder.
Imagawa E, Seyama R, Aoi H, Uchiyama Y, Marcarini BG, Furquim I, Honjo RS, Bertola DR, Kim CA, Matsumoto N. | 03/7/2023 |
| The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex. | The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex.
Shirahama Y, Yamamoto K. | 02/14/2023 |
| SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels. | SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels.
Chen Y, Liu H, Zeng L, Li L, Lu D, Liu Z, Fu R. | 07/30/2022 |
| JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation. | JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation.
Tavares M, Khandelwal G, Muter J, Viiri K, Beltran M, Brosens JJ, Jenner RG., Free PMC Article | 06/11/2022 |
| RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. | RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells.
Gupta SK, Jea JD, Yen L., Free PMC Article | 02/19/2022 |
| DEP Domain Containing 1 Promotes Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Enhancing Expression of Suppressor of Zest 12. | DEP Domain Containing 1 Promotes Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Enhancing Expression of Suppressor of Zest 12.
Wang Q, Jiang S, Liu J, Ma G, Zheng J, Zhang Y. | 10/9/2021 |
| HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression. | HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression.
Yang Q, Wang Y, Li M, Wang Z, Zhang J, Dai W, Pei M, Hong L, Xiao Y, Hu H, Li J, Lin J, Wu X, Chen Y, Huang M, Li A, Liu S, Tang W, Xiang L, Wang J., Free PMC Article | 07/24/2021 |
| The relationship between chimeric RNAs and gene fusions: Potential implications of reciprocity in cancer. | The relationship between chimeric RNAs and gene fusions: Potential implications of reciprocity in cancer.
Elfman J, Pham LP, Li H., Free PMC Article | 07/10/2021 |
| Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway. | Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway.
Liu J, Zhao H, Zhang Q, Shi Z, Zhang Y, Zhao L, Ren Y, Ou R, Xu Y. | 03/13/2021 |
| Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. | Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.
Youmans DT, Gooding AR, Dowell RD, Cech TR., Free PMC Article | 02/27/2021 |
| we confirmed that miR-487b is a CRC suppressor that prevents the EMT process and targets MYC, SUZ12, and KRAS to inhibit the proliferation, migration and invasion of CRC cells. Meanwhile, miR-487b is negatively regulated by DNA methylation | DNA methylation-regulated and tumor-suppressive roles of miR-487b in colorectal cancer via targeting MYC, SUZ12, and KRAS.
Chen X, Lin ZF, Xi WJ, Wang W, Zhang D, Yang F, Li YF, Huo Y, Zhang TZ, Jiang YH, Qin WW, Yang AG, Wang T., Free PMC Article | 05/16/2020 |
| review the PRC2 complex and clinical syndromes of overgrowth and intellectual disability associated with core components EZH2, EED, and SUZ12 | PRC2-complex related dysfunction in overgrowth syndromes: A review of EZH2, EED, and SUZ12 and their syndromic phenotypes.
Cyrus S, Burkardt D, Weaver DD, Gibson WT. | 05/9/2020 |
| Pathogenic SUZ12 variants may be de novo or inherited, and are sometimes inherited from a mildly-affected parent | Rare SUZ12 variants commonly cause an overgrowth phenotype.
Cyrus SS, Cohen ASA, Agbahovbe R, Avela K, Yeung KS, Chung BHY, Luk HM, Tkachenko N, Choufani S, Weksberg R, Lopez-Rangel E, C.A.U.S.E.S. Study, Brown K, Saenz MS, Svihovec S, McCandless SE, Bird LM, Garcia AG, Gambello MJ, McWalter K, Schnur RE, An J, Jones SJM, Bhalla SK, Pinz H, Braddock SR, Gibson WT. | 05/9/2020 |
| Identification of mutations in the PRC2 components EED and SUZ12 in the majority of MPNSTs may imply noncanonical oncogenic activities of the intact component, EZH2, and provide new opportunities for therapeutic intervention. | Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.
Korfhage J, Lombard DB., Free PMC Article | 05/2/2020 |
| Here we show that CRISPR/Cas9-mediated inactivation of Suz12 cooperates with mutant JAK3 to drive T-cell transformation and T-cell acute lymphoblastic leukemia development | Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.
Broux M, Prieto C, Demeyer S, Vanden Bempt M, Alberti-Servera L, Lodewijckx I, Vandepoel R, Mentens N, Gielen O, Jacobs K, Geerdens E, Vicente C, de Bock CE, Cools J., Free PMC Article | 02/8/2020 |
| TRG-AS1 promotes glioblastoma cell proliferation by acting as a ceRNA of miR-877-5p to regulate SUZ12 expression | LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression.
Xie H, Shi S, Chen Q, Chen Z. | 01/18/2020 |
| Results found that SUZ12 expression is negatively regulated by miR767 which binds to the SUZ12 3'UTR in glioma cells, leading to downregulation of its protein. | miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12.
Zhang J, Xu S, Xu J, Li Y, Zhang J, Zhang J, Lu X., Free PMC Article | 12/28/2019 |
| SUZ12 is indispensable for USP3-mediated oncogenic activity in gastric cancer. | Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer.
Wu X, Liu M, Zhu H, Wang J, Dai W, Li J, Zhu D, Tang W, Xiao Y, Lin J, Zhang W, Sun Y, Zhang Y, Chen Y, Li G, Li A, Xiang L, Liu S, Wang J., Free PMC Article | 12/14/2019 |
| SUZ12 protein is significantly up-regulated and associates with cervical node metastasis in primary head and neck squamous cell carcinoma.SUZ12 might serve as a putative oncogene by promoting cell proliferation, migration and invasion in head and neck squamous cell carcinoma. | SUZ12 is a novel putative oncogene promoting tumorigenesis in head and neck squamous cell carcinoma.
Wu Y, Hu H, Zhang W, Li Z, Diao P, Wang D, Zhang W, Wang Y, Yang J, Cheng J., Free PMC Article | 12/14/2019 |
| These data provide strong evidence that SUZ12 mutations cause Weaver-like syndrome. | Novel SUZ12 mutations in Weaver-like syndrome.
Imagawa E, Albuquerque EVA, Isidor B, Mitsuhashi S, Mizuguchi T, Miyatake S, Takata A, Miyake N, Boguszewski MCS, Boguszewski CL, Lerario AM, Funari MA, Jorge AAL, Matsumoto N. | 11/16/2019 |
| We find that co-occupancy of PLZF and EZH2 on chromatin at PLZF target genes is not associated with SUZ12 or trimethylated lysine 27 of histone H3 (H3K27me3) but with the active histone mark H3K4me3 and active transcription. Removal of EZH2 leads to an increase of PLZF binding and increased gene expression. | Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity.
Koubi M, Poplineau M, Vernerey J, N'Guyen L, Tiberi G, Garciaz S, El-Kaoutari A, Maqbool MA, Andrau JC, Guillouf C, Saurin AJ, Duprez E., Free PMC Article | 07/27/2019 |
| Case Report: JAZF1/SUZ12 translocation in a low-grade endometrioid stromal sarcoma originating in the paratestis. | Low-grade Endometrioid Stromal Sarcoma of the Paratestis: A Novel Report With Molecular Confirmation of JAZF1/SUZ12 Translocation.
Agaimy A, Moskalev EA, Weisser W, Bach T, Haller F, Hartmann A. | 03/23/2019 |
| Nucleosome binding enabled by Jarid2 and Aebp2 is in part accounted for by the structures, which also reveal that disruption of the Jarid2-Suz12 interaction may underlie the disease mechanism of an oncogenic chromosomal translocation of Suz12. | Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
Chen S, Jiao L, Shubbar M, Yang X, Liu X., Free PMC Article | 01/5/2019 |