| Targetable leukaemia dependency on noncanonical PI3Kgamma signalling. | Targetable leukaemia dependency on noncanonical PI3Kγ signalling.
Luo Q, Raulston EG, Prado MA, Wu X, Gritsman K, Whalen KS, Yan K, Booth CAG, Xu R, van Galen P, Doench JG, Shimony S, Long HW, Neuberg DS, Paulo JA, Lane AA. | 06/26/2024 |
| PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors. | PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors.
Quintanilha JCF, Racioppi A, Wang J, Etheridge AS, Denning S, Peña CE, Skol AD, Crona DJ, Lin D, Innocenti F., Free PMC Article | 03/12/2022 |
| HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression. | HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression.
Liu Y, Jing XB, Wang ZC, Han QK., Free PMC Article | 02/5/2022 |
| G protein betagamma translocation to the Golgi apparatus activates MAPK via p110gamma-p101 heterodimers. | G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.
Khater M, Wei Z, Xu X, Huang W, Lokeshwar BL, Lambert NA, Wu G., Free PMC Article | 08/28/2021 |
| data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. | Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.
Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B., Free PMC Article | 09/26/2015 |
| PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. | Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma.
Khor GH, Froemming GR, Zain RB, Abraham MT, Thong KL. | 07/25/2015 |
| expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. | p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.
Shymanets A, Prajwal, Bucher K, Beer-Hammer S, Harteneck C, Nürnberg B., Free PMC Article | 01/4/2014 |
| Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. | A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia.
Al Tassan N, Khalil D, Shinwari J, Al Sharif L, Bavi P, Abduljaleel Z, Abu Dhaim N, Magrashi A, Bobis S, Ahmed H, Alahmed S, Bohlega S. | 05/19/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group., Free PMC Article | 06/24/2009 |
| Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas | Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival.
Johnson C, Marriott SJ, Levy LS. | 01/21/2010 |
| p101 has a role in membrane recruitment and activation of PI3K gamma | Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.
Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B., Free PMC Article | 01/21/2010 |
| analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma | Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma.
Voigt P, Brock C, Nürnberg B, Schaefer M. | 01/21/2010 |