| TAP-ing into the cross-presentation secrets of dendritic cells. | TAP-ing into the cross-presentation secrets of dendritic cells.
Yee Mon KJ, Blander JM. | 08/10/2023 |
| Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells. | Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells.
Li Z, Lou Y, Tian G, Wu J, Lu A, Chen J, Xu B, Shi J, Yang J., Free PMC Article | 11/21/2020 |
| SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations. | SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.
Costa R, Todt D, Zapatero-Belinchón F, Schenk C, Anastasiou OE, Walker A, Hertel B, Timmer L, Bojkova D, Ruckert M, Sarrazin C, Timm J, Lohmann V, Manns MP, Steinmann E, von Hahn T, Ciesek S. | 09/26/2020 |
| Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC). | The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca(2+) signaling.
Gong B, Shen W, Xiao W, Meng Y, Meng A, Jia S., Free PMC Article | 02/10/2018 |
| hTAP1 reduces the in vitro activity of the phosphatidylinositol-3-kinase gamma (PI3Kgamma) indicating the formation of a stalled/inactive hTAP1/PI3Kgamma heterodimer. | Modulation of phosphorylation of tocopherol and phosphatidylinositol by hTAP1/SEC14L2-mediated lipid exchange.
Zingg JM, Libinaki R, Meydani M, Azzi A., Free PMC Article | 10/17/2015 |
| PI3Kgamma-induced VEGF expression was reduced when the human tocopherol-associated protein 1 (hTAP1/SEC14L2) was overexpressed suggesting formation of an inactive PI3Kgamma/hTAP1 heterodimer. | Induction of VEGF expression by alpha-tocopherol and alpha-tocopheryl phosphate via PI3Kγ/PKB and hTAP1/SEC14L2-mediated lipid exchange.
Zingg JM, Azzi A, Meydani M. | 09/26/2015 |
| SEC14L2 enabled RNA replication of diverse HCV genotypes in several human hepatoma cell lines | SEC14L2 enables pan-genotype HCV replication in cell culture.
Saeed M, Andreo U, Chung HY, Espiritu C, Branch AD, Silva JM, Rice CM., Free PMC Article | 09/26/2015 |
| novel association between the rs737723 polymorphism (SEC14L2/TAP) and higher primary open-angle glaucoma risk | Effects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucoma.
Zanon-Moreno V, Asensio-Marquez EM, Ciancotti-Oliver L, Garcia-Medina JJ, Sanz P, Ortega-Azorin C, Pinazo-Duran MD, Ordovás JM, Corella D., Free PMC Article | 09/7/2013 |
| TAP expression was significantly correlated with Her2/neu receptor expression and breast cancer stage. | Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development.
Tam KW, Ho CT, Lee WJ, Tu SH, Huang CS, Chen CS, Lee CH, Wu CH, Ho YS. | 08/31/2013 |
| Discusses cloning of rat SEC14-like protein 3 and mentions three human SPF-related genes, known as SEC14-like protein 1, 2 and 3. | Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.
Mokashi V, Singh DK, Porter TD. | 02/16/2012 |
| Fndings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis. | Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.
Wang X, Ni J, Hsu CL, Johnykutty S, Tang P, Ho YS, Lee CH, Yeh S. | 01/21/2010 |
| These findings are consistent with alpha-tocopherol-associated protein acting as an antiproliferative factor in estrogen-receptor-positive luminal cells in normal/benign breast tissue | Dual expression of alpha-tocopherol-associated protein and estrogen receptor in normal/benign human breast luminal cells and the downregulation of alpha-tocopherol-associated protein in estrogen-receptor-positive breast carcinomas.
Johnykutty S, Tang P, Zhao H, Hicks DG, Yeh S, Wang X. | 01/21/2010 |
| Genetic variation in TTPA and SEC14L2 is associated with serum alpha-tocopherol but does not have a direct effect on prostate cancer when vitamin E is administered. | Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk.
Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D, Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D., Free PMC Articles: PMC2644342, PMC2644342 | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesAssociation of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk.
Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D, Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q. | 03/25/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. | 09/24/2008 |
| Data report the three-dimensional crystal structure of human supernatant protein factor in complex with RRR-alpha-tocopherylquinone, the major physiological oxidation product of RRR-alpha-tocopherol, at a resolution of 1.95A. | Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis.
Stocker A, Baumann U. | 01/21/2010 |
| phosphorylation enhances its ability to stimulate microsomal squalene monooxygenase; phosphorylation may provide a means for the rapid short term modulation of cholesterol synthesis | Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase.
Singh DK, Mokashi V, Elmore CL, Porter TD. | 01/21/2010 |
| TAP not only mediates vitamin E absorption to facilitate vitamin E antiproliferation effect in prostate cancer cells, but also functions like a tumor suppressor gene to control cancer cell viability through a non-vitamin E manner. | Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway.
Ni J, Wen X, Yao J, Chang HC, Yin Y, Zhang M, Xie S, Chen M, Simons B, Chang P, di Sant'Agnese A, Messing EM, Yeh S. | 01/21/2010 |
| reduced expression of TAP was associated with the cell proliferation status of prostate cancer, adverse pathological parameters and the increased risk of recurrence | Reduced expression of alpha-tocopherol-associated protein is associated with tumor cell proliferation and the increased risk of prostate cancer recurrence.
Wen XQ, Li XJ, Su ZL, Liu Y, Zhou XF, Cai YB, Huang WT, Gao X. | 01/21/2010 |
| SPF has two domain topology, and the ligand binding cavity has a peculiar horseshoe-like shape | Crystal structure of the human supernatant protein factor.
Stocker A, Tomizaki T, Schulze-Briese C, Baumann U. | 01/21/2010 |