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    FOSL2 FOS like 2, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 2355, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells.

    FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells.
    Du H, Sun J, Wang X, Zhao L, Liu X, Zhang C, Wang F, Wu J.

    10/28/2024
    Role of Fra-2 in cancer.

    Role of Fra-2 in cancer.
    Rampioni Vinciguerra GL, Capece M, Scafetta G, Rentsch S, Vecchione A, Lovat F, Croce CM., Free PMC Article

    02/12/2024
    Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.

    Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.
    Zhang S, Li P, Li J, Gao J, Qi Q, Dong G, Liu X, Jiao Q, Wang Y, Du L, Zhan H, Xu S, Wang C., Free PMC Article

    10/19/2023
    Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.

    Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.
    Yu L, Zhang F, Wang Y.

    09/25/2023
    LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis.

    LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis.
    Chen H, Wang L, Liu J, Wan Z, Zhou L, Liao H, Wan R., Free PMC Article

    06/30/2023
    Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors.

    Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors.
    Ding M, Huang W, Liu G, Zhai B, Yan H, Zhang Y., Free PMC Article

    05/24/2023
    FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects.

    FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects.
    Cospain A, Rivera-Barahona A, Dumontet E, Gener B, Bailleul-Forestier I, Meyts I, Jouret G, Isidor B, Brewer C, Wuyts W, Moens L, Delafontaine S, Keung Lam WW, Van Den Bogaert K, Boogaerts A, Scalais E, Besnard T, Cogne B, Guissard C, Rollier P, Carre W, Bouvet R, Tarte K, Gómez-Carmona R, Lapunzina P, Odent S, Faoucher M, Dubourg C, Ruiz-Pérez VL, Devriendt K, Pasquier L, Pérez-Jurado LA.

    12/17/2022
    Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition.

    Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition.
    Kang SH, Kim HB, Choi JS.

    11/19/2022
    Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.

    Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.
    Ma W, Niu Z, Han D, Wang B, Wang X.

    07/16/2022
    A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.

    A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.
    Shetty A, Tripathi SK, Junttila S, Buchacher T, Biradar R, Bhosale SD, Envall T, Laiho A, Moulder R, Rasool O, Galande S, Elo LL, Lahesmaa R., Free PMC Article

    06/11/2022
    Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer.

    Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer.
    Arnold S, Kortland J, Maltseva DV, Nersisyan SA, Samatov TR, Lezius S, Tonevitsky AG, Milde-Langosch K, Wicklein D, Schumacher U, Stürken C., Free PMC Article

    05/28/2022
    Inhibition of FOSL2 aggravates the apoptosis of ovarian cancer cells by promoting the formation of inflammasomes.

    Inhibition of FOSL2 aggravates the apoptosis of ovarian cancer cells by promoting the formation of inflammasomes.
    Li J, Zhou L, Jiang H, Lin L, Li Y., Free PMC Article

    03/5/2022
    Nucleolar localization of c-Jun.

    Nucleolar localization of c-Jun.
    Miyake T, McDermott JC.

    02/19/2022
    Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b.

    Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b.
    Chen GL, Li R, Chen XX, Wang J, Cao S, Song R, Zhao MC, Li LM, Hannemmann N, Schett G, Qian C, Bozec A., Free PMC Article

    01/29/2022
    KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.

    KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.
    Zhang Q, Zheng Y, Ning M, Li T., Free PMC Article

    10/16/2021
    LncRNA GSTM3TV2 Promotes Cell Proliferation and Invasion via miR-597/FOSL2 Axis in Hepatocellular Carcinoma.

    LncRNA GSTM3TV2 Promotes Cell Proliferation and Invasion via miR-597/FOSL2 Axis in Hepatocellular Carcinoma.
    Hu Y, Qiu W, Kong Z, Wu S, Liu Y, Zhu C, Qin X., Free PMC Article

    09/25/2021
    FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts.

    FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts.
    Wan X, Guan S, Hou Y, Qin Y, Zeng H, Yang L, Qiao Y, Liu S, Li Q, Jin T, Qiu Y, Liu M., Free PMC Article

    08/7/2021
    Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA5973p/FOSL2 pathway.

    Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA‑597‑3p/FOSL2 pathway.
    Gao L, Jin HJ, Zhang D, Lin Q., Free PMC Article

    07/3/2021
    The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis.

    The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis.
    Seidenberg J, Stellato M, Hukara A, Ludewig B, Klingel K, Distler O, Błyszczuk P, Kania G., Free PMC Article

    04/17/2021
    microRNA-143-3p contributes to inflammatory reactions by targeting FOSL2 in PBMCs from patients with autoimmune diabetes mellitus.

    microRNA-143-3p contributes to inflammatory reactions by targeting FOSL2 in PBMCs from patients with autoimmune diabetes mellitus.
    Pan S, Li M, Yu H, Xie Z, Li X, Duan X, Huang G, Zhou Z.

    03/6/2021
    LINC00313 is upregulated in osteosarcoma (OS), and LINC00313 knockdown plays a vital anti-tumor role in OS cell progression through a miR-342-3p/FOSL2 axis.

    LncRNA LINC00313 Knockdown Inhibits Tumorigenesis and Metastasis in Human Osteosarcoma by Upregulating FOSL2 through Sponging miR-342-3p.
    Chen H, Wahafu P, Wang L, Chen X., Free PMC Article

    07/4/2020
    Fra-2 was significantly increased in kidney biopsies of lupus nephritis patients compared with healthy controls and other kidney disease in glomerular podocytes.

    Fra-2 is a novel candidate drug target expressed in the podocytes of lupus nephritis.
    Xu C, Miao Y, Pi Q, Zhu S, Li F.

    10/12/2019
    Results suggest that FOSL2 is a critical regulator of colorectal cancer metastasis.

    Fos-like antigen 2 (FOSL2) promotes metastasis in colon cancer.
    Li S, Fang XD, Wang XY, Fei BY.

    09/28/2019
    there was a negative correlation between miR-133a and FOSL2 expression in Hepatocellular carcinoma samples.

    MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway.
    Sun L, Guo Z, Sun J, Li J, Dong Z, Zhang Y, Chen J, Kan Q, Yu Z.

    01/26/2019
    this study indicates the existence of an aberrant miR-124-3p/Fra-2 pathway that results in glioma aggressiveness

    MiR-124-3p suppresses glioma aggressiveness via targeting of Fra-2.
    Luo L, Chi H, Ling J.

    12/22/2018
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