| WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-kappaB activation. | WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation.
Lim YX, Lin H, Chu T, Lim YP., Free PMC Article | 04/2/2022 |
| WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex. | WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex.
Tabatabaeian H, Lim SK, Chu T, Seah SH, Lim YP., Free PMC Article | 12/4/2021 |
| WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression. | WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
Han Q, Rong X, Lin X, Zhang X, Fan C, Zhao H, Wang E., Free PMC Article | 10/16/2021 |
| WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKbeta1. | WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1.
Zheng Z, Li Y, Fan S, An J, Luo X, Liang M, Zhu F, Huang K., Free PMC Article | 09/18/2021 |
| WBP2 promotes gastric cancer cell migration via novel targeting of LATS2 kinase in the Hippo tumor suppressor pathway. | WBP2 promotes gastric cancer cell migration via novel targeting of LATS2 kinase in the Hippo tumor suppressor pathway.
Hum M, Tan HJ, Yang Y, Srivastava S, Teh M, Lim YP. | 07/17/2021 |
| The emerging roles of WBP2 oncogene in human cancers. | The emerging roles of WBP2 oncogene in human cancers.
Tabatabaeian H, Rao A, Ramos A, Chu T, Sudol M, Lim YP., Free PMC Article | 11/28/2020 |
| WBP2 expression correlates with the response of HER2-positive breast cancer to trastuzumab-based neoadjuvant chemotherapy. | Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study.
Kang SA, Guan JS, Tan HJ, Chu T, Thike AA, Bernadó C, Arribas J, Wong CY, Tan PH, Gudi M, Putti TC, Sohn J, Lim SH, Lee SC, Lim YP. | 05/30/2020 |
| Overexpression of WBP2 in glioma cells promoted cell proliferation and migration, and the number of S-phase cells. | WW domain-binding protein 2 acts as an oncogene by modulating the activity of the glycolytic enzyme ENO1 in glioma.
Chen S, Zhang Y, Wang H, Zeng YY, Li Z, Li ML, Li FF, You J, Zhang ZM, Tzeng CM., Free PMC Article | 11/2/2019 |
| WBP2 directly promoted P-glycoprotein expression through binding to ERalpha to increase the doxorubicin resistance of ERalpha-positive MCF-7 cells. | Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription.
Chen S, Wang H, Li Z, You J, Wu QW, Zhao C, Tzeng CM, Zhang ZM., Free PMC Article | 08/31/2019 |
| WBP2 promoted triple-negative breast cancer (TNBC) growth by integrating JNK with Wnt signaling, and its expression profoundly influenced the sensitivity of TNBC to JNK/TNIK inhibitors. | The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway.
Li Z, Lim SK, Liang X, Lim YP., Free PMC Article | 04/13/2019 |
| Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. | A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.
Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM., Free PMC Article | 12/22/2018 |
| WBP2/ITCH signaling functions to link the intricate Wnt and Hippo signaling networks in breast cancer. | Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.
Lim SK, Lu SY, Kang SA, Tan HJ, Li Z, Adrian Wee ZN, Guan JS, Reddy Chichili VP, Sivaraman J, Putti T, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong W, Lim YP. | 08/12/2017 |
| the miR-206/WBP2 axis can modulate tamoxifen sensitivity via regulating G1/S progression in estrogen receptor + breast cancer | WBP2 modulates G1/S transition in ER+ breast cancer cells and is a direct target of miR-206.
Ren YQ, Wang HJ, Zhang YQ, Liu YB. | 06/24/2017 |
| The authors reported that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse, as well as in two deaf children, each carrying two different variants in the WBP2 gene. | Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.
Buniello A, Ingham NJ, Lewis MA, Huma AC, Martinez-Vega R, Varela-Nieto I, Vizcay-Barrena G, Fleck RA, Houston O, Bardhan T, Johnson SL, White JK, Yuan H, Marcotti W, Steel KP., Free PMC Article | 12/17/2016 |
| data indicate that WBP-2 enhances ER transactivation function at certain genes by facilitating the recruitment and/or the stabilization of a histone modifier enzyme that favors a relaxed chromatin structure, permissive of transcription | Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling.
Buffa L, Saeed AM, Nawaz Z. | 06/8/2013 |
| The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP2 and WBP1 in a highly promiscuous and subtle manner. | Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.
McDonald CB, McIntosh SK, Mikles DC, Bhat V, Deegan BJ, Seldeen KL, Saeed AM, Buffa L, Sudol M, Nawaz Z, Farooq A., Free PMC Article | 12/24/2011 |
| Data show that direct interaction of Wbp2 with TAZ depends on the WW domain of TAZ. | WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ.
Chan SW, Lim CJ, Huang C, Chong YF, Gunaratne HJ, Hogue KA, Blackstock WP, Harvey KF, Hong W., Free PMC Article | 04/23/2011 |
| WW domain binding protein-2, an E6-associated protein interacting protein, acts together with YAP as coactivators of estrogen and progesterone receptors. | WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.
Dhananjayan SC, Ramamoorthy S, Khan OY, Ismail A, Sun J, Slingerland J, O'Malley BW, Nawaz Z. | 01/21/2010 |