| Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods. | Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.
Kozlova AA, Vaganova AN, Rodionov RN, Gainetdinov RR, Bernhardt N., Free PMC Article | 10/22/2022 |
| Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population. | Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population.
Faramarzi E, Aftabi Y, Ansarin K, Somi MH, Gilani N, Seyedrezazadeh E., Free PMC Article | 11/22/2021 |
| DDAH2 rs9267551 polymorphism is significantly associated with myocardial infarction in type 2 diabetes mellitus patients of European ancestry. | A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients.
Mannino GC, Pezzilli S, Averta C, Fuoco A, Spiga R, Mancuso E, Di Fatta C, Perticone F, Prudente S, Trischitta V, Andreozzi F, Sesti G., Free PMC Article | 05/9/2020 |
| The presence of the rs805305 SNP in the DDAH2 gene was determined using genomic DNA extraction from buffy coat and whole blood samples by LGC group (Hertfordshire, UK). | Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.
Lambden S, Tomlinson J, Piper S, Gordon AC, Leiper J., Free PMC Article | 06/22/2019 |
| genetic variations in the DDAH2 gene may influence the ADMA concentration and erythropoietin resistance in MHD patients | Association of the -449GC and -1151AC polymorphisms in the DDAH2 gene with asymmetric dimethylarginine and erythropoietin resistance in Chinese patients on maintenance hemodialysis.
Wang T, Zhang Y, Niu K, Wang L, Shi Y, Liu B. | 04/7/2018 |
| The main finding from this study was that it demonstrated that the C-allele of rs3087894 in DDAH1 is a risk factor for hypertension in the Kazakh group but a protective factor in the Uygur group. In addition, we did not find any genotype of DDAH1 and DDAH2 associated with hypertension in the Han group. | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China.
Wang Z, Chen S, Zhang L, Lu G, Zhou C, Wang DW, Wang L, Badengmu B, Zhai Z, Qin L., Free PMC Article | 05/6/2017 |
| Exogenous human DDAH2 gene promotes differentiation of rabbit bone marrow-derived endothelial progenitor cells into mature endothelial cells. | Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro.
Shoeibi S, Mohammadi S, Sadeghnia HR, Mahdipour E, Ghayour-Mobarhan M. | 03/18/2017 |
| expression of DDAH2 is associated with invasiveness of lung adenocarcinoma via tumor angiogenesis | Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma.
Shiozawa T, Iyama S, Toshima S, Sakata A, Usui S, Minami Y, Sato Y, Hizawa N, Noguchi M., Free PMC Article | 08/13/2016 |
| Inhibiting the expression of DDAH1, but not DDAH2, resulted in a significant increase in the sensitivity of the EVT cell line SGHPL-4 to tumour necrosis factor related apoptosis inducing ligand (TRAIL) induced apoptosis | Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL.
Lumicisi BA, Cartwright JE, Leslie K, Wallace AE, Whitley GS., Free PMC Article | 04/16/2016 |
| increased ADMA levels in rheumatoid arthritis do not appear to relate to DDAH genetic polymorphisms | Relationship between dimethylarginine dimethylaminohydrolase gene variants and asymmetric dimethylarginine in patients with rheumatoid arthritis.
Dimitroulas T, Sandoo A, Hodson J, Smith J, Panoulas VF, Kitas GD. | 08/15/2015 |
| The percentage of senescent endothelial progenitor cells increased while the expression of DDAH2 decreased concomitantly with an increase in the plasma levels of asymmetric dimethylarginine in patients with type 2 diabetes mellitus. | Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine.
Yuan Q, Hu CP, Gong ZC, Bai YP, Liu SY, Li YJ, Jiang JL. | 05/30/2015 |
| DDAH-1 is a specific molecular target for portal pressure reduction, through actions on ADMA-mediated regulation of eNOS activity. | Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension.
Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed Fel Z, Davies N, Sharma V, Iwakiri Y, Jalan R., Free PMC Article | 04/4/2015 |
| Our results suggest that the rs805304 C allele of the DDAH gene was associated with decreased risk of myocardial infarction and decreased risk of obesity. | Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction.
Pérez-Hernández N, Vargas-Alarcón G, Arellano-Zapoteco R, Martínez-Rodríguez N, Fragoso JM, Aptilon-Duque G, Posadas-Sánchez R, Posadas-Romero C, Juárez-Cedillo T, Domínguez-López ML, Rodríguez-Pérez JM. | 02/7/2015 |
| Homocysteine disrupts EPCs function via inducing the hypermethylation of DDAH2 promoter, suggesting a key role of epigenetic mechanism in the progression of atherosclerosis | Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients.
Niu PP, Cao Y, Gong T, Guo JH, Zhang BK, Jia SJ., Free PMC Article | 12/20/2014 |
| -476 to -469 of the DDAH2 promoter was a NF-kB responsive element and is important for the transactivation of DDAH2. | [Identification of a NFB responsive element within the dimethylarginine dimethylaminohydrolase 2 gene promoter].
Li Y, Li J, Sun L, Chu G, Zhao Y. | 08/9/2014 |
| The rs9267551 functional variant of the DDAH2 gene is associated with chronic kidney disease with carriers of the C allele having a lower risk of renal dysfunction independently from several confounders | A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease.
Sesti G, Mannino GC, De Lorenzo C, Greco A, Sciacqua A, Marini MA, Andreozzi F, Perticone F. | 05/31/2014 |
| Our approaches revealed signature candidates of differentially hypermethylated genes of DDAH2 and DUSP1 which can be further developed as potential biomarkers for OSCC as diagnostic, prognostic and therapeutic targets in the future. | DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma.
Khor GH, Froemming GR, Zain RB, Abraham MT, Omar E, Tan SK, Tan AC, Vincent-Chong VK, Thong KL., Free PMC Article | 05/24/2014 |
| Enhancing pulmonary DDAH II activity attenuates LPS-mediated lung leak in acute lung injury. | Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.
Aggarwal S, Gross CM, Kumar S, Dimitropoulou C, Sharma S, Gorshkov BA, Sridhar S, Lu Q, Bogatcheva NV, Jezierska-Drutel AJ, Lucas R, Verin AD, Catravas JD, Black SM., Free PMC Article | 04/26/2014 |
| There is a significant difference in distribution of DDAH2 gene polymorphism among hemodialysis patients compared to healthy individuals. | Distribution of dimethylarginine-dimethylaminohydrolase-II (DDAH2) gene polymorphism in hemodialysis patients.
Thaha M, Yusuf M, Empitu MA, Bakarman A, Tomino Y. | 10/19/2013 |
| DDAH2-1151 A/C polymorphism is associated with Chronic renal impairment in type 2 diabetes. | Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects.
Marra M, Marchegiani F, Ceriello A, Sirolla C, Boemi M, Franceschi C, Spazzafumo L, Testa I, Bonfigli AR, Cucchi M, Testa R. | 10/19/2013 |
| Glucose-stimulated insulin secretion is increased in Ddah2-transgenic pancreatic islets by 33%, compared to its levels in wild-type mice. | The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H. | 08/3/2013 |
| Suppression of DDAH2 expression is a culprit for homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells. | Protection of DDAH2 overexpression against homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells.
Liu LH, Guo Z, Feng M, Wu ZZ, He ZM, Xiong Y. | 06/1/2013 |
| Found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG+GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population. | Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension.
Seo HA, Kim SW, Jeon EJ, Jeong JY, Moon SS, Lee WK, Kim JG, Lee IK, Park KG. | 04/6/2013 |
| No association was observed between the DDAH2 polymorphisms at rs805305 and rs2272592 and coronary heart disease. | Association study of dimethylarginine dimethylaminohydrolase 2 gene polymorphisms and coronary heart disease.
Xu AG, Xu RM, Lu CQ, Li DD, Xu QF, Guo J, Fu X, Zhao W, Yao MY. | 03/23/2013 |
| A functional polymorphism of the DDAH2 gene may confer increased risk for type 2 diabetes by affecting insulin sensitivity | A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity.
Andreozzi F, Presta I, Mannino GC, Scarpelli D, Di Silvestre S, Di Pietro N, Succurro E, Sciacqua A, Pandolfi A, Consoli A, Hribal ML, Perticone F, Sesti G., Free PMC Article | 09/8/2012 |