| FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway. | FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
Wang L, Mao X, Yu X, Su J, Li Z, Chen Z, Ren Y, Huang H, Wang W, Zhao C, Hu Y. | 07/10/2024 |
| Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver. | Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
Lee C, Han J, Jung Y., Free PMC Article | 03/7/2023 |
| D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. | D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
Nawaz MI, Rezzola S, Tobia C, Coltrini D, Belleri M, Mitola S, Corsini M, Sandomenico A, Caporale A, Ruvo M, Presta M. | 07/10/2021 |
| Low FPR3 expression is associated with obstructive sleep apnea. | Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.
Chen YC, Su MC, Chin CH, Lin IC, Hsu PY, Liou CW, Huang KT, Wang TY, Lin YY, Zheng YX, Hsiao CC, Lin MC., Free PMC Article | 01/25/2020 |
| These findings provide evidence for defective FPR2/3 and annexin A1 expressions that, associated with decreased M2a polarization, might be involved in the development of cigarette smoking induced persistent airflow limitation in chronic obstructive pulmonary disease. | Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.
Chen YC, Lin MC, Lee CH, Liu SF, Wang CC, Fang WF, Chao TY, Wu CC, Wei YF, Chang HC, Tsen CC, Chen HC, Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE) group., Free PMC Article | 06/15/2019 |
| Taken together, our results suggest that intracellular FPR in naive CD4 T cells and surface FPRs in activated CD4 T cells might regulate immune responses by regulating CD4 T cell activity. | Intracellular formyl peptide receptor regulates naïve CD4 T cell migration.
Lee HY, Jeong YS, Lee M, Kweon HS, Huh YH, Park JS, Hwang JE, Kim K, Bae YS. | 03/17/2018 |
| The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis. | Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors.
Wang X, Wang J, Ge B. | 04/12/2014 |
| The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling. | Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors.
Prevete N, Rossi FW, Rivellese F, Lamacchia D, Pelosi C, Lobasso A, Necchi V, Solcia E, Fiocca R, Ceppa P, Staibano S, Mascolo M, D'Argenio G, Romano M, Ricci V, Marone G, De Paulis A. | 03/29/2014 |
| transcriptional variations of FPR3 occur by an alternative promoter during primate evolution. | Transcriptional variations mediated by an alternative promoter of the FPR3 gene.
Ha HS, Huh JW, Gim JA, Han K, Kim HS. | 01/21/2012 |
| F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils | Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M. | 10/29/2011 |
| N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation. | N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation.
Rabiet MJ, Macari L, Dahlgren C, Boulay F., Free PMC Article | 10/1/2011 |
| Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. | The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor.
Montuori N, Bifulco K, Carriero MV, La Penna C, Visconte V, Alfano D, Pesapane A, Rossi FW, Salzano S, Rossi G, Ragno P., Free PMC Article | 10/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Human monocytes express FPR1, FPR2, and FPR3; human neutrophils express FPR1 and FPR2, but not FPR3. | Functional expression of formyl peptide receptor family in human NK cells.
Kim SD, Kim JM, Jo SH, Lee HY, Lee SY, Shim JW, Seo SK, Yun J, Bae YS. | 01/21/2010 |
| FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro in different conditions | Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils.
Devosse T, Guillabert A, D'Haene N, Berton A, De Nadai P, Noel S, Brait M, Franssen JD, Sozzani S, Salmon I, Parmentier M. | 01/21/2010 |
| Human dendritic cells express functional FPRL2 throughout maturation. FPRL2 & its endogenous ligand may be involved in regulating DC trafficking during Ag uptake & processing s well as the T-cell-stimulating phase of the immune responses. | Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.
Yang D, Chen Q, Gertz B, He R, Phulsuksombati M, Ye RD, Oppenheim JJ. | 01/21/2010 |
| investigated the direct effect of LXA4 as well as the effect on agonist-induced biological responses using transfected HL-60 cells expressing FPR, FPRL1 or FPRL2 | Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.
Christophe T, Karlsson A, Rabiet MJ, Boulay F, Dahlgren C. | 01/21/2010 |
| However, F2L inhibits formyl peptide receptor (FPR) and FPRL1 activities, resulting in the inhibition of intracellular calcium increases, and superoxide generation induced by N-formyl-Met-Leu-Phe, MMK-1, or Trp-Lys-Tyr-Met-Val-d-Met in neutrophils. | F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling.
Lee HY, Lee SY, Shin EH, Kim SD, Kim JM, Lee MS, Ryu SH, Bae YS. | 01/21/2010 |
| an annexin 1 peptide can activate FPR, FPRL1, and FPRL2; results indicate that annexin 1 participates in regulating leukocyte emigration into inflamed tissue by activating and desensitizing different receptors of the FPR family. | An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.
Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U. | 01/21/2010 |
| Results show that humanin (HN) acts as a ligand for formyl peptide receptor-like 1 (FPRL1) and 2 (FPRL2). | N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.
Harada M, Habata Y, Hosoya M, Nishi K, Fujii R, Kobayashi M, Hinuma S. | 01/21/2010 |
| Activation of FPRL2 inhibits lipopolysaccharide-induced dendritic cell maturation. | The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.
Kang HK, Lee HY, Kim MK, Park KS, Park YM, Kwak JY, Bae YS. | 01/21/2010 |