| Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia. | Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
Ikhlef L, Yassine M, Chandouri B, Rivière L, Naves T, Dmytruk N, Gachard N, Jauberteau MO, Gallet PF., Free PMC Article | 03/15/2024 |
| Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review). | Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
Yang Y, Zhang W, Wei K, Hu F, Wu S, Ma Y, Ouyang Q. | 03/12/2024 |
| Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications. | Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
Qiu S, Nikolaou S, Zhu J, Jeffery P, Goldin R, Kinross J, Alexander JL, Rasheed S, Tekkis P, Kontovounisios C., Free PMC Article | 02/20/2021 |
| A novel role of NTS in the development of Castration-resistant prostate cancer with Neuroendocrine differentiation (NED), and a possible strategy to prevent the onset of NED by targeting the NTS signaling pathway. | Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.
Zhu S, Tian H, Niu X, Wang J, Li X, Jiang N, Wen S, Chen X, Ren S, Xu C, Chang C, Flores-Morales A, Shang Z, Sun Y, Niu Y., Free PMC Article | 12/14/2019 |
| High NTSR2 expression is associated with B-cell chronic lymphocytic leukemia. | Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis.
Abbaci A, Talbot H, Saada S, Gachard N, Abraham J, Jaccard A, Bordessoule D, Fauchais AL, Naves T, Jauberteau MO., Free PMC Article | 03/16/2019 |
| We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined. | Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.
Kim JT, Weiss HL, Evers BM., Free PMC Article | 03/3/2018 |
| high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells | Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
Kim JT, Li J, Song J, Lee EY, Weiss HL, Townsend CM Jr, Evers BM., Free PMC Article | 08/20/2016 |
| NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells. | Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
Saada S, Marget P, Fauchais AL, Lise MC, Chemin G, Sindou P, Martel C, Delpy L, Vidal E, Jaccard A, Troutaud D, Lalloué F, Jauberteau MO. | 01/26/2013 |
| this study proposes a novel function of NTR2 in the regulation of NTR1 activity. | Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.
Hwang JR, Baek MW, Sim J, Choi HS, Han JM, Kim YL, Hwang JI, Kwon HB, Beaudet N, Sarret P, Seong JY. | 03/22/2010 |
| NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+) | Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.
Swift SL, Burns JE, Maitland NJ. | 02/1/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesEvidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
Dick DM, Meyers J, Aliev F, Nurnberger J Jr, Kramer J, Kuperman S, Porjesz B, Tischfield J, Edenberg HJ, Foroud T, Schuckit M, Goate A, Hesselbrock V, Bierut L. Genetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. | 01/11/2009 |
| NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue. | Expression of neurotensin and its receptors in pituitary adenomas.
Giorgi RR, Chile T, Bello AR, Reyes R, Fortes MA, Machado MC, Cescato VA, Musolino NR, Bronstein MD, Giannella-Neto D, Corrêa-Giannella ML. | 01/21/2010 |
| ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII | Common structural basis for constitutive activity of the ghrelin receptor family.
Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW. | 01/21/2010 |
| Recycling ability depends on a single tyrosine residue | Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.
Martin S, Vincent JP, Mazella J. | 01/21/2010 |