| results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. | Targeting prion-like protein doppel selectively suppresses tumor angiogenesis.
Al-Hilal TA, Chung SW, Choi JU, Alam F, Park J, Kim SW, Kim SY, Ahsan F, Kim IS, Byun Y., Free PMC Article | 08/20/2016 |
| The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. | PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease.
Flirski M, Sieruta M, Golańska E, Kłoszewska I, Liberski PP, Sobów T., Free PMC Article | 08/11/2012 |
| in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression | Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy.
Rognoni P, Chiarelli LR, Comincini S, Azzalin A, Miracco C, Valentini G., Free PMC Article | 02/26/2011 |
| Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. | Transient expressions of doppel and its structural analog prionDelta32-121 in SH-SY5Y cells caused cytotoxicity possibly by triggering similar apoptosis pathway.
Xu K, Wang X, Tian C, Shi S, Wang GR, Shi Q, Li P, Zhou RM, Jiang HY, Chu YL, Dong XP. | 10/4/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| From the logistic regression ananlsis of this stidy showed that the highest risk for was found for Alzheimer's disease individuals who co-inherited APOE epsilon4 allele, PRNP codon 129 homozygosity, PRND codon 174 Thr allele, and CYP46 rs754203 g allele. | Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes.
Golanska E, Hulas-Bigoszewska K, Sieruta M, Zawlik I, Witusik M, Gresner SM, Sobow T, Styczynska M, Peplonska B, Barcikowska M, Liberski PP, Corder EH, Golanska E, Hulas-Bigoszewska K, Sieruta M, Zawlik I, Witusik M, Gresner SM, Sobow T, Styczynska M, Peplonska B, Barcikowska M, Liberski PP, Corder EH. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes.
Golanska E, Hulas-Bigoszewska K, Sieruta M, Zawlik I, Witusik M, Gresner SM, Sobow T, Styczynska M, Peplonska B, Barcikowska M, Liberski PP, Corder EH, Golanska E, Hulas-Bigoszewska K, Sieruta M, Zawlik I, Witusik M, Gresner SM, Sobow T, Styczynska M, Peplonska B, Barcikowska M, Liberski PP, Corder EH. | 04/29/2009 |
| results suggested that the function of Dpl is antagonistic to PrP rather than synergistic | Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein.
Li P, Dong C, Lei Y, Shan B, Xiao X, Jiang H, Wang X, Gao C, Shi Q, Xu K, Tian C, Han J, Dong X. | 01/21/2010 |
| Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. | The doppel (Dpl) protein influences in vitro migration capability in astrocytoma-derived cells.
Azzalin A, Sbalchiero E, Barbieri G, Palumbo S, Muzzini C, Comincini S., Free PMC Article | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.
Croes EA, Alizadeh BZ, Bertoli-Avella AM, Rademaker T, Vergeer-Drop J, Dermaut B, Houwing-Duistermaat JJ, Wientjens DP, Hofman A, Van Broeckhoven C, van Duijn CM. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesSignificant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study.
Vollmert C, Windl O, Xiang W, Rosenberger A, Zerr I, Wichmann HE, Bickeböller H, Illig T, KORA group, Kretzschmar HA. Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients.
Geldermann H, Bartenschlager H, Preuss S, Melchinger-Wild E, Herzog K, Zerr I. Polymorphism at 3' UTR +28 of the prion-like protein gene is associated with sporadic Creutzfeldt-Jakob disease.
Jeong BH, Kim NH, Choi EK, Lee C, Song YH, Kim JI, Carp RI, Kim YS. Polymorphisms at codons 56 and 174 of the prion-like protein gene (PRND) are not associated with sporadic Creutzfeldt-Jakob disease.
Jeong BH, Kim NH, Kim JI, Carp RI, Kim YS. Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD.
Golanska E, Hulas-Bigoszewska K, Rutkiewicz E, Styczynska M, Peplonska B, Barcikowska M, Bratosiewicz-Wasik J, Liberski PP. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.
Schröder B, Franz B, Hempfling P, Selbert M, Jürgens T, Kretzschmar HA, Bodemer M, Poser S, Zerr I. | 03/13/2008 |
| Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. | [Expression of recombinant human doppel protein and analysis of its cytotoxic activities].
Li P, Han J, Shan B, Lei YJ, Zhou W, Jiang HY, Dong XP. | 01/21/2010 |
| Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. | Diagnostic value of PRND gene expression profiles in astrocytomas: relationship to tumor grades of malignancy.
Comincini S, Ferrara V, Arias A, Malovini A, Azzalin A, Ferretti L, Benericetti E, Cardarelli M, Gerosa M, Passarin MG, Turazzi S, Bellazzi R. | 01/21/2010 |
| Dpl interacts with RACK1 by means of its structured globular carboxyl-terminal region | The prion-like protein Doppel (Dpl) interacts with the human receptor for activated C-kinase 1 (RACK1) protein.
Azzalin A, Del Vecchio I, Ferretti L, Comincini S. | 01/21/2010 |
| Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. | Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob disease.
Peoc'h K, Volland H, De Gassart A, Beaudry P, Sazdovitch V, Sorgato MC, Creminon C, Laplanche JL, Lehmann S. | 01/21/2010 |
| expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs | The human "prion-like" protein Doppel is expressed in both Sertoli cells and spermatozoa.
Peoc'h K, Serres C, Frobert Y, Martin C, Lehmann S, Chasseigneaux S, Sazdovitch V, Grassi J, Jouannet P, Launay JM, Laplanche JL. | 01/21/2010 |
| Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. | Spatio-developmental distribution of the prion-like protein doppel in Mammalian testis: a comparative analysis focusing on its presence in the acrosome of spermatids.
Serres C, Peoc'h K, Courtot AM, Lesaffre C, Jouannet P, Laplanche JL. | 01/21/2010 |
| Doppel interacts with the full-length laminin receptor precursor protein | Interaction of Doppel with the full-length laminin receptor precursor protein.
Yin SM, Sy MS, Yang HY, Tien P. | 01/21/2010 |
| human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour | The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two-hybrid system.
Hundt C, Weiss S. | 01/21/2010 |
| results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane | Human Doppel and prion protein share common membrane microdomains and internalization pathways.
Massimino ML, Ballarin C, Bertoli A, Casonato S, Genovesi S, Negro A, Sorgato MC. | 01/21/2010 |