| LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients. | LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients.
Wanka G, Schmoeckel E, Mayr D, Fuerst S, Kuhn C, Mahner S, Knabl J, Karsten MM, Dannecker C, Heidegger HH, Vattai A, Jeschke U, Jueckstock J., Free PMC Article | 05/15/2021 |
| LDOC1 is differentially expressed in thyroid cancer and display tumor-suppressive function in papillary thyroid carcinoma. | LDOC1 is differentially expressed in thyroid cancer and display tumor-suppressive function in papillary thyroid carcinoma.
Zhao S, Zhao Y, Wang Q, Li Z, Ma X, Wu L, Li W, Du M, Ji H, Qin G. | 11/21/2020 |
| Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway. | Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway.
Zhao C, Du F, Zhao Y, Wang S, Qi L., Free PMC Article | 09/5/2020 |
| LDOC1 is a tumor suppressor in Colorectal cancer (CRC) and it inhibits cell proliferation and promotes cell apoptosis. Additionally, it inhibits CRC cell metastasis by downregulating the Wnt/betacatenin signaling pathway. | Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.
Jiang J, Li Y, Jiang Z., Free PMC Article | 08/17/2019 |
| that epigenetic silencing of LDOC1 in high-risk Group A ependymoma regulates tumor biology and drives inflammatory immune phenotype | NF-κB upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma.
Griesinger AM, Witt DA, Grob ST, Georgio Westover SR, Donson AM, Sanford B, Mulcahy Levy JM, Wong R, Moreira DC, DeSisto JA, Balakrishnan I, Hoffman LM, Handler MH, Jones KL, Vibhakar R, Venkataraman S, Foreman NK., Free PMC Article | 06/16/2018 |
| GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis. | Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation.
Thoompumkal IJ, Rehna K, Anbarasu K, Mahalingam S., Free PMC Article | 06/24/2017 |
| These finding of this study suggested that the hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with Klinefelter Syndrome. | LDOC1 Gene Expression in Men With Klinefelter Syndrome.
Salemi M, Condorelli RA, Longo G, Bullara V, Romano C, Campagna C, Bosco P, La Vignera S, Calogero AE., Free PMC Article | 04/1/2017 |
| data show that LDOC1 is a tumor suppressor in osteosarcoma, and that it regulates metastasis of osteosarcoma cells. Furthermore, LDOC1 might be a valuable prognostic marker in osteosarcomas. | LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients.
Yong BC, Lu JC, Xie XB, Su Q, Tan PX, Tang QL, Wang J, Huang G, Han J, Xu HW, Shen JN. | 03/11/2017 |
| Cigarette smoke-induced promoter methylation may contribute to LDOC1 downregulation, thereby conferring oncogenic features to oral cells. | LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation.
Lee CH, Pan KL, Tang YC, Tsai MH, Cheng AJ, Shen MY, Cheng YM, Huang TT, Lin P., Free PMC Article | 07/30/2016 |
| LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-kappaB activation in papillary thyroid carcinoma | LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-κB activation in papillary thyroid carcinoma.
Zhao S, Wang Q, Li Z, Ma X, Wu L, Ji H, Qin G., Free PMC Article | 07/2/2016 |
| It has potential roles in apoptosis of well differentiated carcinoma without metastases and in neurodegeneration of Alzheimer's disease. | CASP3 and LDOC-1 gene expression in a patient with carcinoma in the hairy part of the head skin and Alzheimer disease.
Salemi M, Soma PF, Bosco P, Vicari E, Castiglione R, Calogero AE. | 03/29/2014 |
| Silencing of LDOC1 is a frequent event in cervical cancer and may be of interest as a molecular marker in cervical cancer. | Loss of LDOC1 expression by promoter methylation in cervical cancer cells.
Buchholtz ML, Jückstock J, Weber E, Mylonas I, Dian D, Brüning A. | 12/21/2013 |
| Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence. | Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma.
Lee CH, Wong TS, Chan JY, Lu SC, Lin P, Cheng AJ, Chen YJ, Chang JS, Hsiao SH, Leu YW, Li CI, Hsiao JR, Chang JY. | 08/31/2013 |
| Letter/Case Report: LDOC1/PARP1 are down-regulated in melanoma with repeated in-transit metastases. | Two proapoptotic genes are downregulated in a patient with melanoma and repeated in-transit metastases.
Salemi M, Giuffrida D, Soma PF, Giuffrida MC, Galia A, Calogero AE. | 09/29/2012 |
| The aim of this study was to evaluate the possible differential expression of LDOC1 mRNA in leucocytes of peripheral blood of Down's syndrome subjects. compared with the normal population. | Expression of LDOC1 mRNA in leucocytes of patients with Down's syndrome.
Salemi M, Barone C, Romano C, Ridolfo F, Salluzzo R, Scillato F, Scavuzzo C, Caraci F, Calogero AE, Romano C, Bosco P. | 09/8/2012 |
| Over expression of LDOC1 may explain the clinical manifestation found in patients with cryptochidism and Digeorge anomaly. | Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly.
Salemi M, Castiglione R, La Vignera S, Condorelli RA, Bosco P, Vicari E, Calogero AE. | 12/17/2011 |
| LDOC1 is dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases, and have identified a new splice variant, LDOC1S | LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients.
Duzkale H, Schweighofer CD, Coombes KR, Barron LL, Ferrajoli A, O'Brien S, Wierda WG, Pfeifer J, Majewski T, Czerniak BA, Jorgensen JL, Medeiros LJ, Freireich EJ, Keating MJ, Abruzzo LV., Free PMC Article | 06/25/2011 |
| These observations suggest that LDOC1 is a novel regulator of NF-kappaB that can affect the PMA or TNF-alpha-mediated pathway to apoptosis through inhibition of NF-kappaB activation in BxPC3 pancreatic cancer cells. | Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis.
Nagasaki K, Schem C, von Kaisenberg C, Biallek M, Rösel F, Jonat W, Maass N. | 01/21/2010 |
| MZF-1 was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis | LDOC1, a novel MZF-1-interacting protein, induces apoptosis.
Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C. | 01/21/2010 |