| Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress. | Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress.
Magg V, Manetto A, Kopp K, Wu CC, Naghizadeh M, Lindner D, Eke L, Welsch J, Kallenberger SM, Schott J, Haucke V, Locker N, Stoecklin G, Ruggieri A. | 05/10/2024 |
| Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers. | Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y., Free PMC Article | 03/1/2024 |
| The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP). | The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP).
Hicks D, Giresh K, Wrischnik LA, Weiser DC., Free PMC Article | 01/12/2024 |
| Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation. | Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.
Li H, Li W, Zhang S, Qiu M, Li Z, Lin Y, Tan J, Qiao W., Free PMC Article | 03/12/2022 |
| Substrate recognition determinants of human eIF2alpha phosphatases. | Substrate recognition determinants of human eIF2α phosphatases.
Hodgson G, Andreeva A, Bertolotti A., Free PMC Article | 03/5/2022 |
| Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF. | Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Monkley S, Overed-Sayer C, Parfrey H, Rassl D, Crowther D, Escudero-Ibarz L, Davis N, Carruthers A, Berks R, Coetzee M, Kolosionek E, Karlsson M, Griffin LR, Clausen M, Belfield G, Hogaboam CM, Murray LA., Free PMC Article | 01/29/2022 |
| Higher-order phosphatase-substrate contacts terminate the integrated stress response. | Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Yan Y, Harding HP, Ron D., Free PMC Article | 11/27/2021 |
| GADD34 plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Hence, the TFEB-GADD34 axis integrates the mTORC1 and ISR pathways in response to starvation. | GADD34 is a modulator of autophagy during starvation.
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, di Bernardo D., Free PMC Article | 03/4/2021 |
| these findings suggest that GADD34 inhibits TRAIL-induced HCC cell apoptosis through TRAF6- and ERK-mediated stabilization of MCL-1. | The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells.
Song P, Yang S, Hua H, Zhang H, Kong Q, Wang J, Luo T, Jiang Y., Free PMC Article | 10/19/2019 |
| The results highlighted a novel role for the GADD34/PP1alpha complex in coordinating the dephosphorylation and reactivation of eIF2alpha and SIRT1 to determine cell fate following oxidative stress. | Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Lee IC, Ho XY, George SE, Goh CW, Sundaram JR, Pang KKL, Luo W, Yusoff P, Sze NSK, Shenolikar S., Free PMC Article | 08/24/2019 |
| Depletion of HES1 increased cell death in response to endoplasmic reticulum stress in mouse and human cells, in a manner that depended on the pro-apoptotic gene growth arrest and DNA damage-inducible protein GADD34. | Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress-induced apoptosis through repression of GADD34.
Lee JE, Morrison W, Hollien J., Free PMC Article | 01/12/2019 |
| Findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1 and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies. | Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.
Goh CW, Lee IC, Sundaram JR, George SE, Yusoff P, Brush MH, Sze NSK, Shenolikar S., Free PMC Article | 12/1/2018 |
| Loss of GADD34 cause vanishing white matter disease due to translation defects. | EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Moon SL, Parker R., Free PMC Article | 07/28/2018 |
| Compared with normal controls, the wild type TT and allele T of rs611251 of PPP1R15A showed higher frequency in gastric carcinoma, nasopharyngeal carcinomas and lymphomas. | Relationship between PPP1R15A gene polymorphism (rs611251) and Epstein-Barr virus-associated tumors.
Song Y, Liu S, Zhao Z, Zhang Y, Yang Y, Luo B. | 05/12/2018 |
| Inhibition of IRE1 modifies the hypoxic regulation of GADD34 family gene expression in cultured glioma cells. | Inhibition of IRE1 modifies the hypoxic regulation of GADD family gene expressions in U87 glioma cells.
Minchenko OH, Kryvdiuk IV, Riabovol OO, Minchenko DO, Danilovskyi SV, Ratushna OO. | 01/20/2018 |
| GADD34 constitutes a mechanistic link between endoplasmic reticulum stress and mTOR inactivation, therefore promotes cell survival during endoplasmic reticulum stress. | GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy.
Holczer M, Bánhegyi G, Kapuy O., Free PMC Article | 07/8/2017 |
| reduction of GADD34 expression significantly suppressed tumor, and resulted in decreased accumulation of MDSCs and T-cells, and inhibition of GADD34 reduced secretion of vascular epithelial growth factor alpha and transforming growth factor beta by MDSCs | GADD34 Promotes Tumor Growth by Inducing Myeloid-derived Suppressor Cells.
Liu L, Ito S, Nishio N, Sun Y, Tanaka Y, Isobe K. | 02/18/2017 |
| ANXA11 rs1049550 and PPP1R15A rs557806 may improve the identification of mCRC patients sensitive to bevacizumab regimens, and further validation is required in large cohorts | Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancer.
Roh SA, Park IJ, Yoon YS, Kwon YH, Chung JH, Kim TW, Cho DH, Lim BH, Kim SK, Kim SY, Kim YS, Kim JC. | 02/18/2017 |
| Data of this study strengthen the evidence of an unfolded protein response during the course of RA and provide an insight of the potential interest in GADD34 as a relevant marker for RA. | Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies.
Clavarino G, Adriouach S, Quesada JL, Clay M, Chevreau M, Trocmé C, Grange L, Gaudin P, Gatti E, Pierre P, Cesbron JY, Dumestre-Pérard C. | 12/31/2016 |
| The results suggest that dephosphorylation of eIF2a by GADD34 plays an important role in doxorubicin resistance of MCF-7/ADR cells. | Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells.
Jeon YJ, Kim JH, Shin JI, Jeong M, Cho J, Lee K., Free PMC Article | 11/5/2016 |
| The reactive oxygen species-generating NADPH oxidase-4 (Nox4) is induced downstream of ATF4, binds to a PP1-targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 activity to increase eIF2alpha phosphorylation and ATF4 levels. | Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.
Santos CX, Hafstad AD, Beretta M, Zhang M, Molenaar C, Kopec J, Fotinou D, Murray TV, Cobb AM, Martin D, Zeh Silva M, Anilkumar N, Schröder K, Shanahan CM, Brewer AC, Brandes RP, Blanc E, Parsons M, Belousov V, Cammack R, Hider RC, Steiner RA, Shah AM., Free PMC Article | 06/28/2016 |
| stress pathways lead to the induction of the protein GADD34, which appears to provide protection against the toxic effects of the secreted virulence factors in Pseudomonas aeruginosa infection | Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
van 't Wout EF, van Schadewijk A, van Boxtel R, Dalton LE, Clarke HJ, Tommassen J, Marciniak SJ, Hiemstra PS., Free PMC Article | 04/9/2016 |
| The data highlight independent interactions of PP1 and eIF2alpha with GADD34, demonstrating that GADD34 functions as a scaffold both in vitro and in cells | Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
Choy MS, Yusoff P, Lee IC, Newton JC, Goh CW, Page R, Shenolikar S, Peti W., Free PMC Article | 03/26/2016 |
| GADD34 may play a neuroprotective role against amyloid-beta toxicity. | Induction of GADD34 Regulates the Neurotoxicity of Amyloid β.
Xu N, Xiao Z, Zou T, Huang Z., Free PMC Article | 02/20/2016 |
| GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS combined with amino acid deprivation through regulation of mTOR signaling pathway in macrophages. | GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy.
Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K., Free PMC Article | 11/28/2015 |