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    TRIM29 tripartite motif containing 29 [ Homo sapiens (human) ]

    Gene ID: 23650, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency.

    O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency.
    Zhao FY, Chen X, Wang JM, Yuan Y, Li C, Sun J, Wang HQ.

    07/24/2024
    Silencing TRIM29 Sensitizes Non-small Cell Lung Cancer Cells to Anlotinib by Promoting Apoptosis via Binding RAD50.

    Silencing TRIM29 Sensitizes Non-small Cell Lung Cancer Cells to Anlotinib by Promoting Apoptosis via Binding RAD50.
    Wu M, Jin MM, Cao XH, Zhao L, Li YH.

    06/1/2024
    TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC.

    TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC.
    Huang W, Hu X, He X, Pan D, Huang Z, Gu Z, Huang G, Wang P, Cui C, Fan Y.

    05/28/2024
    TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.

    TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.
    Yin YT, Shi L, Wu C, Zhang MY, Li JX, Zhou YF, Wang SC, Wang HY, Mai SJ.

    04/3/2024
    TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer.

    TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer.
    Jiang T, Xia Y, Li Y, Lu C, Lin J, Shen Y, Lv J, Xie L, Gu C, Xu Z, Wang L.

    12/21/2023
    NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.

    NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.
    Xiao B, Ge Y, Zhao R, Zhang Y, Guo Y, Zhang S, Li B, Qiu P, Chao Z, Zuo S.

    11/14/2023
    lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.

    lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
    Huang J, Yuan W, Chen B, Li G, Chen X., Free PMC Article

    05/23/2023
    Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.

    Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.
    Cha MY, Hong YJ, Choi JE, Kwon TS, Kim IJ, Hong KW., Free PMC Article

    08/20/2022
    Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.

    Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.
    Smits JPH, Dirks RAM, Qu J, Oortveld MAW, Brinkman AB, Zeeuwen PLJM, Schalkwijk J, Zhou H, Marks H, van den Bogaard EH., Free PMC Article

    04/2/2022
    TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer.

    TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer.
    Qiao HY, Zhang Q, Wang JM, Jiang JY, Huyan LY, Yan J, Li C, Wang HQ.

    02/26/2022
    TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.

    TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
    Wikiniyadhanee R, Lerksuthirat T, Stitchantrakul W, Chitphuk S, Sura T, Dejsuphong D., Free PMC Article

    11/27/2021
    E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1.

    E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1.
    Deng X, Fu X, Teng H, Fang L, Liang B, Zeng R, Chen L, Zou Y., Free PMC Article

    09/11/2021
    TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell.

    TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell.
    Lei G, Liu S, Yang X, He C., Free PMC Article

    08/21/2021
    Long noncoding RNA TP73AS1 accelerates the progression and cisplatin resistance of nonsmall cell lung cancer by upregulating the expression of TRIM29 via competitively targeting microRNA34a5p.

    Long non‑coding RNA TP73‑AS1 accelerates the progression and cisplatin resistance of non‑small cell lung cancer by upregulating the expression of TRIM29 via competitively targeting microRNA‑34a‑5p.
    Luo S, Shen M, Chen H, Li W, Chen C., Free PMC Article

    05/1/2021
    TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells.

    TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells.
    Wu T, Zhang DL, Wang JM, Jiang JY, Du X, Zeng XY, Du ZX., Free PMC Article

    04/24/2021
    m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells.

    m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells.
    Hao L, Wang JM, Liu BQ, Yan J, Li C, Jiang JY, Zhao FY, Qiao HY, Wang HQ.

    04/17/2021
    TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin.

    TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin.
    Xu W, Chen B, Ke D, Chen X., Free PMC Article

    03/13/2021
    Study demonstrated that extracellular free ISG15 played an important role in maintenance of cancer stem cell-like features of pancreatic ductal adenocarcinoma (PDAC) and revealed a novel mechanism by which TRIM29 modulates ISG15 stability via CAPN3-mediated processing, and subsequently extracellular ISG15 maintains the cancer stem cell-like features of PDAC via autocrine mode of action.

    Loss of TRIM29 suppresses cancer stem cell-like characteristics of PDACs via accelerating ISG15 degradation.
    Sun J, Yan J, Qiao HY, Zhao FY, Li C, Jiang JY, Liu BQ, Meng XN, Wang HQ.

    06/20/2020
    TRIM29 has a role in regulating the distribution of keratins, as well as in the migration and invasion of squamous cell carcinoma

    Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma.
    Yanagi T, Watanabe M, Hata H, Kitamura S, Imafuku K, Yanagi H, Homma A, Wang L, Takahashi H, Shimizu H, Hatakeyama S.

    10/12/2019
    High TRIM29 expression is associated with invasion in hepatocellular carcinoma.

    MicroRNA-424-5p acts as a potential biomarker and inhibits proliferation and invasion in hepatocellular carcinoma by targeting TRIM29.
    Du H, Xu Q, Xiao S, Wu Z, Gong J, Liu C, Ren G, Wu H.

    05/25/2019
    Results show that the depletion of tripartite motif-containing 29 protein (TRIM29) promoted liver cancer cell proliferation, clone formation, migration and invasion in vitro probably through the Wnt/beta-catenin signaling pathway.

    TRIM29 prevents hepatocellular carcinoma progression by inhibiting Wnt/β-catenin signaling pathway.
    Xu M, Hu J, Zhou B, Zhong Y, Lin N, Xu R.

    05/25/2019
    decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC.

    MicroRNA‑122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro.
    Yang Y, Li Q, Guo L., Free PMC Article

    09/29/2018
    Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma.

    High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma.
    Zeng SX, Cai QC, Guo CH, Zhi LQ, Dai X, Zhang DF, Ma W.

    04/28/2018
    Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus.

    TRIM29 promotes DNA virus infections by inhibiting innate immune response.
    Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z., Free PMC Article

    03/10/2018
    the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways.

    TRIM29 Overexpression Promotes Proliferation and Survival of Bladder Cancer Cells through NF-κB Signaling.
    Tan ST, Liu SY, Wu B., Free PMC Article

    02/3/2018
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