| In vivo interaction screening reveals liver-derived constraints to metastasis. | In vivo interaction screening reveals liver-derived constraints to metastasis.
Borrelli C, Roberts M, Eletto D, Hussherr MD, Fazilaty H, Valenta T, Lafzi A, Kretz JA, Guido Vinzoni E, Karakatsani A, Adivarahan S, Mannhart A, Kimura S, Meijs A, Baccouche Mhamedi F, Acar IE, Handler K, Ficht X, Platt RJ, Piscuoglio S, Moor AE., Free PMC Article | 08/9/2024 |
| Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability. | Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.
Smith CEL, Laugel-Haushalter V, Hany U, Best S, Taylor RL, Poulter JA, Wortmann SB, Feichtinger RG, Mayr JA, Al Bahlani S, Nikolopoulos G, Rigby A, Black GC, Watson CM, Mansour S, Inglehearn CF, Mighell AJ, Bloch-Zupan A, UK Inherited Retinal Disease Consortium, Genomics England Research Consortium., Free PMC Article | 07/10/2024 |
| Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor. | Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
Hu A, Nussbaum YI, Mitchem J, Yoo J. | 03/20/2024 |
| Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia. | Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
Guo Z, Guo D, Kong D, Bian S, Zhao L, Li Q, Lin L, Hao J, Sun L, Li Y. | 09/26/2023 |
| CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis. | CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
Wang J, Wu C, Zhou W. | 06/7/2023 |
| Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival. | Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
Yang H, Yuan L, Ibaragi S, Li S, Shapiro R, Vanli N, Goncalves KA, Yu W, Kishikawa H, Jiang Y, Hu AJ, Jay D, Cochran B, Holland EC, Hu GF., Free PMC Article | 08/13/2022 |
| Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding. | Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
Yu Y, Zhou Y, Di C, Zhao C, Chen J, Su W, Wu Q, Wu M, Su X, Xia Z., Free PMC Article | 02/26/2022 |
| Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion. | Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonça JP, Azeloglu EU, Zou H, Friedel RH., Free PMC Article | 11/13/2021 |
| Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics. | Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Huang Y, Tejero R, Lee VK, Brusco C, Hannah T, Bertucci TB, Junqueira Alves C, Katsyv I, Kluge M, Foty R, Zhang B, Friedel CC, Dai G, Zou H, Friedel RH., Free PMC Article | 08/14/2021 |
| Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis. | Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
Bai R, Sun D, Chen M, Shi X, Luo L, Yao Z, Liu Y, Ge X, Gao X, Hu GF, Zhou W, Sheng J, Xu Z., Free PMC Article | 04/13/2021 |
| Plexin-B2 in psoriasis; a clinical and immunohistochemical study. | Plexin-B2 in psoriasis; a clinical and immunohistochemical study.
Hemida AS, Mareae AH, Elbasiony ASA, Shehata WA. | 02/13/2021 |
| Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly. | Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly.
Atkin-Smith GK, Miles MA, Tixeira R, Lay FT, Duan M, Hawkins CJ, Phan TK, Paone S, Mathivanan S, Hulett MD, Chen W, Poon IKH. | 09/19/2020 |
| PLEXIN-B2 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the RhoA signaling pathway. | PLEXIN-B2 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the RhoA signaling pathway.
Zhang Y, Shen S, Li P, Fan Y, Zhang L, Li W, Liu Y. | 08/22/2020 |
| data indicate that Sema4C/PlexinB2 signaling is essential for the growth of breast carcinoma cells, featuring a novel potential therapeutic target. In addition, elevated Sema4C expression enables indolent luminal-type tumors to become resistant to estrogen deprivation, invasive and metastatic in vivo | Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential.
Gurrapu S, Pupo E, Franzolin G, Lanzetti L, Tamagnone L., Free PMC Article | 09/21/2019 |
| Study data showed that cooperation of CD100 and PlxnB2 promoted the inflammatory responses in keratinocytes by activating NF-kappaB and the NLRP3 inflammasome and participated in the pathogenesis of psoriasis. | CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-κB and the Inflammasome in Keratinocytes.
Zhang C, Xiao C, Dang E, Cao J, Zhu Z, Fu M, Yao X, Liu Y, Jin B, Wang G, Li W. | 03/9/2019 |
| Knocking down of PLXNB2 with PLXNB2 siRNA results in repressed ovarian cancer cell proliferation and invasion, and decreased phosphorylation of AKT and ERK1/2 | MiR-126-3p inhibits ovarian cancer proliferation and invasion via targeting PLXNB2.
Xiang G, Cheng Y. | 12/22/2018 |
| Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells. | Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.
Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF., Free PMC Article | 11/25/2017 |
| Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity. | Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.
Wylie T, Garg R, Ridley AJ, Conte MR., Free PMC Article | 11/4/2017 |
| plexin-B2 is a downstream target for Rnd3, which contributes to its cellular function. | Rnd3-induced cell rounding requires interaction with Plexin-B2.
McColl B, Garg R, Riou P, Riento K, Ridley AJ., Free PMC Article | 08/12/2017 |
| Results show that decreased expression of Sema4D, plexin-B1 and -B2 was associated with local recurrence and poor prognosis of breast neoplasm. | Reduced expression of semaphorin 4D and plexin-B in breast cancer is associated with poorer prognosis and the potential linkage with oestrogen receptor.
Malik MF, Ye L, Jiang WG. | 04/30/2016 |
| Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. | Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.
Pascoe HG, Gutowski S, Chen H, Brautigam CA, Chen Z, Sternweis PC, Zhang X., Free PMC Article | 04/16/2016 |
| Plexin-B2 promotes glioma invasion and vascularization | Plexin-B2 promotes invasive growth of malignant glioma.
Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH., Free PMC Article | 01/16/2016 |
| Blocking of CD100, plexin B1 and/or B2 in adhesion experiments have shown that both CD100 and plexins act as adhesion molecules involved in monocyte-endothelial cell binding. | CD100 and plexins B2 and B1 mediate monocyte-endothelial cell adhesion and might take part in atherogenesis.
Luque MC, Gutierrez PS, Debbas V, Kalil J, Stolf BS. | 12/19/2015 |
| In endometrial luminal epithelium, cadherin 6, desmoglein 2 and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity. | Endometrial apical glycoproteomic analysis reveals roles for cadherin 6, desmoglein-2 and plexin b2 in epithelial integrity.
Singh H, Aplin JD. | 08/22/2015 |
| High PLEXIN B2 expression is associated with high-grade gliomas. | Experimental validation of 5 in-silico predicted glioma biomarkers.
Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD., Free PMC Article | 07/12/2014 |