| HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion. | HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
Zhao X, Liu D, Zhao Y, Wang Z, Wang Y, Chen Z, Ning S, Wang G, Meng L, Yao J, Tian X., Free PMC Article | 02/23/2024 |
| TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity. | TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity.
Narita T, Tobisawa Y, Bobkov A, Jackson M, Ohyama C, Irie F, Yamaguchi Y., Free PMC Article | 01/29/2024 |
| Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression. | Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.
Sato S, Miyazaki M, Fukuda S, Mizutani Y, Mizukami Y, Higashiyama S, Inoue S., Free PMC Article | 07/7/2023 |
| Concurrent Overexpression of Two Hyaluronidases, KIAA1199 and TMEM2, Strongly Predicts Shorter Survival After Resection in Pancreatic Ductal Adenocarcinoma. | Concurrent Overexpression of Two Hyaluronidases, KIAA1199 and TMEM2, Strongly Predicts Shorter Survival After Resection in Pancreatic Ductal Adenocarcinoma.
Kudo Y, Sato N, Oba T, Adachi Y, Amaike T, Koga A, Kohi S, Noguchi H, Nakayama T, Hirata K. | 11/26/2022 |
| Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage. | Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage.
Shiozawa J, de Vega S, Yoshinaga C, Ji X, Negishi Y, Momoeda M, Nakamura T, Yoshida H, Kaneko H, Ishijima M, Okada Y., Free PMC Article | 10/22/2022 |
| TMEM2 expression is downregulated as bladder cancer invades the muscle layer. | TMEM2 expression is downregulated as bladder cancer invades the muscle layer.
Yoneyama MS, Yoneyama T, Tobisawa Y, Yamamoto H, Hatakeyama S, Yoneyama T, Hashimoto Y, Suzuki T, Ohyama C. | 06/11/2022 |
| miR-518a-3p Suppresses Triple-Negative Breast Cancer Invasion and Migration Through Regulation of TMEM2. | miR-518a-3p Suppresses Triple-Negative Breast Cancer Invasion and Migration Through Regulation of TMEM2.
Gan L, Yang H, Xiong Z, Yang Z, Wang T, Lyu G., Free PMC Article | 11/27/2021 |
| Transcriptome alterations in HepG2 cells induced by shRNA knockdown and overexpression of TMEM2 gene. | Transcriptome alterations in HepG2 cells induced by shRNA knockdown and overexpression of TMEM2 gene.
Jia X, Mo Z, Zhao Q, Bao T, Xu W, Gao Z, Peng L, Zhu X. | 02/13/2021 |
| ectopic expression of human TMEM2 in C. elegans protected animals from endoplasmic reticulum stress and increased both longevity and pathogen resistance. | The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPR(ER).
Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A., Free PMC Article | 05/30/2020 |
| Findings indicate that hyaluronan-binding protein (HYBID) is indispensable for KIAA1199 (CEMIP)-mediated hyaluronan-B (HA) depolymerization in skin fibroblasts, but transmembrane protein 2 (TMEM2) is not involved in the HYBID-mediated process as a catalytic hyaluronidase. | The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts.
Yoshino Y, Goto M, Hara H, Inoue S. | 06/1/2019 |
| TMEM2 inhibits Hepatitis b virus infection in HepG2 and HepG2.2.15 by activating the JAK-STAT signaling pathway. | TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK-STAT signaling pathway.
Zhu X, Xie C, Li YM, Huang ZL, Zhao QY, Hu ZX, Wang PP, Gu YR, Gao ZL, Peng L., Free PMC Article | 10/14/2017 |
| our findings lead us to propose that TMEM2 may not only mediate the pathologic effects of SOX4 on cancer progression but also potentially its contributions to embryonic development | TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration and Invasion in Breast Cancer.
Lee H, Goodarzi H, Tavazoie SF, Alarcón CR., Free PMC Article | 07/29/2017 |
| Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. | Rare inborn errors associated with chronic hepatitis B virus infection.
Zhao Q, Peng L, Huang W, Li Q, Pei Y, Yuan P, Zheng L, Zhang Y, Deng J, Zhong C, Hu B, Ding H, Fang W, Li R, Liao Q, Lin C, Deng W, Yan H, Hou J, Wu Q, Xu T, Liu J, Hu L, Peng T, Chen S, Lai KN, Yuen MF, Wang Y, Maini MK, Li C, Li M, Wang J, Zhang X, Sham PC, Wang J, Gao ZL, Wang Y. | 01/26/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |