| Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. | Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP., Free PMC Article | 04/30/2022 |
| Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function. | Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.
Clark-Patterson GL, Roy S, Desrosiers L, Knoepp LR, Sen A, Miller KS., Free PMC Article | 01/29/2022 |
| PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. | PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC., Free PMC Article | 01/22/2022 |
| Upregulation of PTK7 and beta-catenin after vaginal mechanical dilatation: an examination of fibulin-5 knockout mice. | Upregulation of PTK7 and β-catenin after vaginal mechanical dilatation: an examination of fibulin-5 knockout mice.
Uemura R, Tachibana D, Shiota M, Yoshida K, Kitada K, Hamuro A, Misugi T, Koyama M. | 11/22/2021 |
| Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus. | Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus.
Eekhoff JD, Steenbock H, Berke IM, Brinckmann J, Yanagisawa H, Wagenseil JE, Lake SP., Free PMC Article | 08/21/2021 |
| Fibulin 5 localized to the RPE, choroid, and Bruch's membrane. Knockout mice had a significantly reduced scotopic A response by 1 month of age, when compared to their wild-type counterparts, which remained throughout life and only declined as a result of normal aging. The functional decline was associated with reduced number of photoreceptor cells. | Role of Fibulins 2 and 5 in Retinal Development and Maintenance.
Ikelle L, Naash MI, Al-Ubaidi MR. | 05/11/2019 |
| Fibulin-5 overexpression promoted the proliferation and migration of airway smooth muscle cell. | Fibulin-5 promotes airway smooth muscle cell proliferation and migration via modulating Hippo-YAP/TAZ pathway.
Fu J, Zheng M, Zhang X, Zhang Y, Chen Y, Li H, Wang X, Zhang J. | 10/21/2017 |
| Fibulin-5 overexpression significantly down-regulated the phosphorylation level of eIF2alpha and subsequently inhibited the TRPV1 channel and CREB/CGRP signaling | Overexpression of Fibulin-5 attenuates burn-induced inflammation via TRPV1/CGRP pathway.
Hou X, Li H, Zhang C, Wang J, Li X, Li X. | 10/14/2017 |
| therapy-induced hypoxia elevated Fbln5 expression, whereas pharmacologic inhibition of TGF-beta signaling reduced Fbln5 expression. These findings offer insight into the signaling axis that induces Fbln5 expression in PDA and a potential strategy to block its production | Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
Topalovski M, Hagopian M, Wang M, Brekken RA., Free PMC Article | 05/27/2017 |
| Identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation in abdominal aortic aneurysms. | Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.
Orriols M, Varona S, Martí-Pàmies I, Galán M, Guadall A, Escudero JR, Martín-Ventura JL, Camacho M, Vila L, Martínez-González J, Rodríguez C. | 02/18/2017 |
| involved in the stiffening of fibrotic tissue | The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.
Nakasaki M, Hwang Y, Xie Y, Kataria S, Gund R, Hajam EY, Samuel R, George R, Danda D, M J P, Nakamura T, Shen Z, Briggs S, Varghese S, Jamora C., Free PMC Article | 05/28/2016 |
| Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce ROS production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease. | Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.
Wang M, Topalovski M, Toombs JE, Wright CM, Moore ZR, Boothman DA, Yanagisawa H, Wang H, Witkiewicz A, Castrillon DH, Brekken RA., Free PMC Article | 04/30/2016 |
| While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative. | Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice.
Noda K, Nakamura T, Komatsu Y., Free PMC Article | 04/23/2016 |
| Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review) | [Diverse functions of fibulin-5 in tumors].
Tang JC, Xie AY, Cai XJ. | 04/18/2015 |
| These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 in regulating fibulin-5 dependent elastic fiber assembly. | Function of latent TGFβ binding protein 4 and fibulin 5 in elastogenesis and lung development.
Dabovic B, Robertson IB, Zilberberg L, Vassallo M, Davis EC, Rifkin DB., Free PMC Article | 01/10/2015 |
| Without LTBP-4, fibulin-5 and tropoelastin deposition was discontinuous and punctate in vitro and in vivo | Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.
Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T., Free PMC Article | 04/27/2013 |
| This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries. | Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation.
Wan W, Gleason RL Jr., Free PMC Article | 04/20/2013 |
| suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility | Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.
Kapustin A, Stepanova V, Aniol N, Cines DB, Poliakov A, Yarovoi S, Lebedeva T, Wait R, Ryzhakov G, Parfyonova Y, Gursky Y, Yanagisawa H, Minashkin M, Beabealashvilli R, Vorotnikov A, Bobik A, Tkachuk V., Free PMC Article | 05/19/2012 |
| MMP9 and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans | Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.
Budatha M, Roshanravan S, Zheng Q, Weislander C, Chapman SL, Davis EC, Starcher B, Word RA, Yanagisawa H., Free PMC Article | 07/16/2011 |
| mechanical testing and confocal imaging of common carotid arteries from fibulin-5 null mice and littermate controls to characterize the mechanical behavior and microstructural content of these arteries | Biomechanical and microstructural properties of common carotid arteries from fibulin-5 null mice.
Wan W, Yanagisawa H, Gleason RL Jr., Free PMC Article | 03/5/2011 |
| These findings introduce a novel function for Fbln5 in the regulation of integrin-induced reactive oxygen species production. | Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.
Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA., Free PMC Article | 09/6/2010 |
| Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury | Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.
Chapman SL, Sicot FX, Davis EC, Huang J, Sasaki T, Chu ML, Yanagisawa H., Free PMC Article | 01/21/2010 |
| Fibulin-5 plays 2 roles in elastogenesis; 1st, limiting the extent of aggregation of tropoelastin monomers and/or coacervates and aiding the incorporation of elastin into the microfibril bundles, & 2nd, potentially assisting in the activation of LOXL-1. | Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly.
Choi J, Bergdahl A, Zheng Q, Starcher B, Yanagisawa H, Davis EC., Free PMC Article | 01/21/2010 |
| Fibulin 5(-/-) mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and increased vaginal protease activity (MMP-2 and MMP-9) precedes the development of prolapse. | Quantification of pelvic organ prolapse in mice: vaginal protease activity precedes increased MOPQ scores in fibulin 5 knockout mice.
Wieslander CK, Rahn DD, McIntire DD, Acevedo JF, Drewes PG, Yanagisawa H, Word RA., Free PMC Article | 01/21/2010 |
| a novel Epithelial-mesenchymal transition and tumor-promoting function for FBLN5 in developing and progressing breast cancers | Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism.
Lee YH, Albig AR, Regner M, Schiemann BJ, Schiemann WP., Free PMC Article | 01/21/2010 |