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    Agtr1a angiotensin II receptor, type 1a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24180, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.

    DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
    Ghosh K, Zhou JJ, Shao JY, Chen SR, Pan HL., Free PMC Article

    02/26/2024
    Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats.

    Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats.
    Paes-Leme B, Monteiro LDRN, Gholami K, Hoe SZ, Ferguson AV, Murphy D, Antunes-Rodrigues J, Rorato R, Reis LC, Mecawi AS.

    12/15/2023
    Astrocytic AT1R deficiency ameliorates Abeta-induced cognitive deficits and synaptotoxicity through beta-arrestin2 signaling.

    Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.
    Chen X, Gao R, Song Y, Xu T, Jin L, Zhang W, Chen Z, Wang H, Wu W, Zhang S, Zhang G, Zhang N, Chang L, Liu H, Li H, Wu Y.

    10/25/2023
    Angiotensin II type 1a receptor knockout ameliorates high-fat diet-induced cardiac dysfunction by regulating glucose and lipid metabolism.

    Angiotensin II type 1a receptor knockout ameliorates high-fat diet-induced cardiac dysfunction by regulating glucose and lipid metabolism.
    Wang J, Li D, Zhang Y, Xing D, Lei Z, Jiao X., Free PMC Article

    09/21/2023
    Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-kappaB pathway.

    Selenium deficiency causes hypertension by increasing renal AT(1) receptor expression via GPx1/H(2)O(2)/NF-κB pathway.
    Lei L, Zhang F, Huang J, Yang X, Zhou X, Yan H, Chen C, Zheng S, Si L, Jose PA, Zeng C, Yang J., Free PMC Article

    05/23/2023
    Maternal exercise upregulates the DNA methylation of Agtr1a to enhance vascular function in offspring of hypertensive rats.

    Maternal exercise upregulates the DNA methylation of Agtr1a to enhance vascular function in offspring of hypertensive rats.
    Shan M, Li S, Zhang Y, Chen Y, Zhou Y, Shi L.

    03/7/2023
    The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis.

    The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis.
    Li A, Shi W, Wang J, Wang X, Zhang Y, Lei Z, Jiao XY., Free PMC Article

    07/16/2022
    The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.

    The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.
    Brasil TFS, Belém-Filho IJA, Fortaleza EAT, Antunes-Rodrigues J, Corrêa FMA.

    04/9/2022
    Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.

    Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
    Chen Y, Li S, Xu Z, Zhang Y, Zhang H, Shi L.

    03/5/2022
    Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame.

    Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame.
    Kadam PS, Mueller SC, Ji H, Liu J, Pai AV, Ma J, Speth RC, Sandberg K.

    01/29/2022
    Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells.

    Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells.
    Gém JB, Kovács KB, Szalai L, Szakadáti G, Porkoláb E, Szalai B, Turu G, Tóth AD, Szekeres M, Hunyady L, Balla A., Free PMC Article

    01/8/2022
    Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant ratsdagger.

    Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats†.
    Mishra JS, Kumar S., Free PMC Article

    12/25/2021
    Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.

    Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.
    Gao H, Du WY, Lin J, Han SL, Zhang YJ, Sun XF.

    12/25/2021
    Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring.

    Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring.
    Hu C, Tao Y, Deng Y, Cai Q, Ren H, Yu C, Zheng S, Yang J, Zeng C., Free PMC Article

    12/18/2021
    Evidence that angiotensin II does not directly stimulate the MD2-TLR4 innate inflammatory pathway.

    Evidence that angiotensin II does not directly stimulate the MD2-TLR4 innate inflammatory pathway.
    Okechukwu CC, Pirro NT, Chappell MC., Free PMC Article

    12/4/2021
    Blockade of ERK1/2 activation with U0126 or PEP7 reduces sodium appetite and angiotensin II-induced pressor responses in spontaneously hypertensive rats.

    Blockade of ERK1/2 activation with U0126 or PEP7 reduces sodium appetite and angiotensin II-induced pressor responses in spontaneously hypertensive rats.
    Andrade-Franzé GMF, Pereira ED Jr, Yosten GLC, Samson WK, Menani JV, De Luca LA Jr, Andrade CAF.

    12/4/2021
    trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-beta in streptozotocin-induced diabetic rats.

    trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats.
    Samadi-Noshahr Z, Ebrahimzadeh-Bideskan A, Hadjzadeh MA, Shafei MN, Salmani H, Hosseinian S, Khajavi-Rad A.

    07/17/2021
    Central AT1 receptor signaling by circulating angiotensin II is permissive to acute intermittent hypoxia-induced sympathetic neuroplasticity.

    Central AT1 receptor signaling by circulating angiotensin II is permissive to acute intermittent hypoxia-induced sympathetic neuroplasticity.
    Shimoura CG, Andrade MA, Toney GM., Free PMC Article

    07/17/2021
    The AT1 receptor autoantibody causes hypoglycemia in fetal rats via promoting the STT3A-GLUT1-glucose uptake axis in liver.

    The AT1 receptor autoantibody causes hypoglycemia in fetal rats via promoting the STT3A-GLUT1-glucose uptake axis in liver.
    Wang P, He C, Yue M, Wang T, Bai L, Wu Y, Liu D, Wang M, Sun Y, Li Y, Zhang S, Liu H.

    07/3/2021
    Human and Rodent Skeletal Muscles Express Angiotensin II Type 1 Receptors.

    Human and Rodent Skeletal Muscles Express Angiotensin II Type 1 Receptors.
    Deminice R, Hyatt H, Yoshihara T, Ozdemir M, Nguyen B, Levine S, Powers S., Free PMC Article

    03/6/2021
    Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.

    Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
    Chao YM, Wu KLH, Tsai PC, Tain YL, Leu S, Lee WC, Chan JYH., Free PMC Article

    11/21/2020
    AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, blocks inflammatory mediators, and upregulates antioxidant enzymes and bone formation markers.

    AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, blocks inflammatory mediators, and upregulates antioxidant enzymes and bone formation markers.
    Dionísio TJ, Souza GP, Colombini-Ishikiriama BL, Garbieri TF, Parisi VA, Oliveira GM, Cano IP, Rodini CO, Oliveira SHP, Greene AS, Santos CF.

    09/19/2020
    Data support the hypothesis that interaction between AT1R and Mas1 contributes to proangiogenic Ang-(1-7) signaling in the skeletal muscle.

    Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats.
    Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS., Free PMC Article

    07/25/2020
    results indicate the expression of angiotensin II receptor type 1a mRNA in the dorsal raphe nucleus and subfornical organ as a marker of sodium depletion

    Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus.
    Porcari CY, Araujo IG, Urzedo-Rodrigues L, De Luca LA Jr, Menani JV, Caeiro XE, Imboden H, Antunes-Rodrigues J, Reis LC, Vivas L, Godino A, Mecawi AS.

    07/25/2020
    AT1a receptors in the median preoptic nucleus contribute to the sustained blood pressure increase to intermittent hypoxia.

    Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension.
    Shell B, Farmer GE, Nedungadi TP, Wang LA, Marciante AB, Snyder B, Cunningham RL, Cunningham JT., Free PMC Article

    02/22/2020
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