| Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats. | Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Shirakami Y, Nakanishi T, Ozawa N, Ideta T, Kochi T, Kubota M, Sakai H, Ibuka T, Tanaka T, Shimizu M., Free PMC Article | 10/23/2021 |
| the miR-30 family/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical. | Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility.
Yuan B, Wu W, Zhang H, Gu H, Guo D, Jiang J, Wang X. | 07/27/2019 |
| Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons | Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.
Veas-Pérez de Tudela M, Maestre C, Delgado-Esteban M, Bolaños JP, Almeida A., Free PMC Article | 10/22/2016 |
| Study shows APC is an RNA-binding protein and identify an RNA interactome; among the targets is beta2B-tubulin, known to be required in human neuron and axon migration; results identify APC as a platform binding functionally related protein and RNA networks, and suggest a self-organizing model for the microtubule to localize synthesis of its own subunits. | APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly.
Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG., Free PMC Article | 10/25/2014 |
| APC is essential for maintenance of intestinal mucosal homeostasis and can consequently contribute to inflammatory bowel disease pathogenesis. | Tumor suppressor APC protein is essential in mucosal repair from colonic inflammation through angiogenesis.
Yoshimi K, Tanaka T, Serikawa T, Kuramoto T. | 08/31/2013 |
| These results point to APC as a crucial regulator of intermediate filament organization. | APC binds intermediate filaments and is required for their reorganization during cell migration.
Sakamoto Y, Boëda B, Etienne-Manneville S., Free PMC Article | 04/6/2013 |
| APC and PSD-95 colocalize and form a protein complex in nerve fibers as well as in postsynaptic sites in matured neurons. | Colocalization of APC and PSD-95 in the nerve fiber as well as in the post-synapse of matured neurons.
Onouchi T, Takamori N, Senda T. | 02/16/2013 |
| the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability. | Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
Pfister AS, Hadjihannas MV, Röhrig W, Schambony A, Behrens J., Free PMC Article | 01/5/2013 |
| results identify a previously unknown APC regulatory pathway during growth-factor-induced cell extension and indicate that the GSK-3beta and ERK pathways act in parallel to regulate interactions between APC and the cytoskeleton during formation of cell extensions | Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension.
Caro-Gonzalez HY, Nejsum LN, Siemers KA, Shaler TA, Nelson WJ, Barth AI., Free PMC Article | 11/24/2012 |
| APC, through a direct interaction with the NPC (nuclear pore complex) protein Nup153 (nucleoporin 153), promotes the association of microtubules with the nuclear membrane. | APC nuclear membrane association and microtubule polarity.
Collin L, Schlessinger K, Hall A. | 01/21/2010 |
| Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity | Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Etienne-Manneville S, Hall A. | 01/21/2010 |
| mutated in 2-AMIQ-induced tumors in various organs in rats | Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
Blum CA, Tanaka T, Zhong X, Li Q, Dashwood WM, Pereira C, Xu M, Dashwood RH., Free PMC Article | 01/21/2010 |
| These results suggest that APC may be involved in neuronal process extension, and that APC may exert different functions on axons and dendritic processes. | Subcellular localization of the tumor suppressor protein APC in developing cultured neurons.
Shimomura A, Kohu K, Akiyama T, Senda T. | 01/21/2010 |
| loss of the wild-type Apc allele in tumors does not involve chromosome loss in rats | A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.
Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, Dove WF., Free PMC Article | 01/21/2010 |
| beta-catenin has a structural role in inhibiting APC function in neurite growth. | Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin.
Votin V, Nelson WJ, Barth AI., Free PMC Article | 01/21/2010 |