| RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis. | RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
Shi H, Duan L, Lan Y, He Q, Pu P, Tang H., Free PMC Article | 02/4/2023 |
| JUN Regulation of Injury-Induced Enhancers in Schwann Cells. | JUN Regulation of Injury-Induced Enhancers in Schwann Cells.
Ramesh R, Manurung Y, Ma KH, Blakely T Jr, Won S, Moreno-Ramos OA, Wyatt E, Awatramani R, Svaren J., Free PMC Article | 09/3/2022 |
| The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy. | The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Tan Y, Cao H, Li Q, Sun J. | 12/25/2021 |
| Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression. | Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression.
Fujita N, Sase K, Tsukahara C, Arizono I, Takagi H, Kitaoka Y., Free PMC Article | 05/29/2021 |
| Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation. | Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation.
Zhan H, Wang Y, Yu S, Cai G, Zeng Y, Ma J, Liu W, Wu W., Free PMC Article | 02/27/2021 |
| The authors show that c-Jun protected H9c2 cells from apoptosis and promoted the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway. | c-Jun promotes the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway.
Wu F, Gao F, He S, Jiang Y, Luo G, Xiao Y. | 04/11/2020 |
| stimulation of B-Raf strongly activated the transcription factor AP-1 which is accompanied by increased c-Jun and c-Fos promoter activities, an upregulation of c-Jun and c-Fos biosynthesis, and elevated transcriptional activation potentials of c-Jun and c-Fos. | Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells.
Langfermann DS, Rössler OG, Thiel G. | 04/27/2019 |
| Gonadotropin-stimulated Kiss1 expression in granulosa cells is dependent on both the activation of ESR2 and the upregulation of AP-1. | ESR2 Is Essential for Gonadotropin-Induced Kiss1 Expression in Granulosa Cells.
Chakravarthi VP, Khristi V, Ghosh S, Yerrathota S, Dai E, Roby KF, Wolfe MW, Rumi MAK., Free PMC Article | 04/20/2019 |
| miR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun. | miR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun.
Ming S, Shui-Yun W, Wei Q, Jian-Hui L, Ru-Tai H, Lei S, Mei J, Hui W, Ji-Zheng W., Free PMC Article | 12/22/2018 |
| These findings indicated that heat stress stimulation in IEC6 cells induced the proapoptotic role of NFkappaB by regulating HSF1 and cJun activation. | NF‑κB regulates HSF1 and c‑Jun activation in heat stress‑induced intestinal epithelial cell apoptosis.
Li J, Liu Y, Duan P, Yu R, Gu Z, Li L, Liu Z, Su L. | 08/4/2018 |
| AMPK is an important negative regulator of Schwann cell myelination in the peripheral nervous system, and this regulation role may rely on c-Jun activation. | AMPK Negatively Regulates Peripheral Myelination via Activation of c-Jun.
Liu X, Peng S, Zhao Y, Zhao T, Wang M, Luo L, Yang Y, Sun C. | 03/10/2018 |
| Data show that miR-672-5p bound to the 3' UTR of the JUN gene, indicating that JUN is a target of miR-672-5p. | A new miRNA regulator, miR-672, reduces cardiac hypertrophy by inhibiting JUN expression.
Lu Y, Wu F. | 03/3/2018 |
| Results suggest that mammalian target of rapamycin (mTOR) may act via transcription factor AP-1 (AP-1) to regulate vascular endothelial growth factor (VEGF) expression. | The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth.
Wang S, Lu J, You Q, Huang H, Chen Y, Liu K., Free PMC Article | 02/3/2018 |
| Carbon monoxide-releasing molecule-2-enhanced HO-1 promoter activity was inhibited by co-transfection with small interfering RNA (siRNA) of c-Jun, specificity protein 1 (Sp1), or nuclear factor-erythroid 2-related factor 2 (Nrf2). | CO Induces Nrf2-Dependent Heme Oxygenase-1 Transcription by Cooperating with Sp1 and c-Jun in Rat Brain Astrocytes.
Chi PL, Lin CC, Chen YW, Hsiao LD, Yang CM. | 08/31/2017 |
| In summary, our results suggest that HO-1 can decrease H/R-induced myocardiac cell apoptosis; the mechanism may be related to the activation of the Akt signaling pathway and, furthermore, to the inhibition of the JNK/c-Jun/caspase-3 signaling pathway. | Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis : The role of JNK/c-Jun/Caspase-3 inhibition and Akt signaling enhancement.
Li C, Zhang C, Wang T, Xuan J, Su C, Wang Y. | 06/24/2017 |
| These findings indicate that c-Jun induces PLCgamma1 expression transcriptionally and enhances rapid epithelial restitution after injury by activating Ca(2+) signal. | c-Jun enhances intestinal epithelial restitution after wounding by increasing phospholipase C-γ1 transcription.
Wang PY, Wang SR, Xiao L, Chen J, Wang JY, Rao JN., Free PMC Article | 06/10/2017 |
| The results suggest that an increase in the expression of PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and importin-alpha3 expression/activity participates in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation during endotoxemia and thus have a beneficial effect in septic shock treatment | Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B. | 12/31/2016 |
| The aim of the present work was to assess the levels of mRNA encoded by genes c-jun and c-fos and the ratio of expression levels of these genes in various regions of the neonatal rat brain after the administration of dexamethasone | [Influence of dexamethasone on the expression of immediate early genes c-fos and c-jun in different regions of the neonatal brain].
Sukhareva EV, Dygalo NN, Kalinina TS. | 07/2/2016 |
| These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells. | Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.
Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV., Free PMC Article | 09/26/2015 |
| These findings indicate that CORM-3 pretreatment interferes with JNK/AP-1 signaling and suppresses LPS-induced upregulation of the proadhesive phenotype in hCMEC/D3. | Pretreatment of human cerebrovascular endothelial cells with CO-releasing molecule-3 interferes with JNK/AP-1 signaling and suppresses LPS-induced proadhesive phenotype.
Serizawa F, Patterson E, Potter RF, Fraser DD, Cepinskas G. | 09/26/2015 |
| Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway. | Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
Wang C, You X, Jiang C, Jin C, Meng X, Ding D. | 04/4/2015 |
| nerve injury induces Schwann cell activation of c-Jun by phosphorylation, which, in contrast to in sensory neurons, is JNK independent. | Nerve injury-induced c-Jun activation in Schwann cells is JNK independent.
Blom CL, Mårtensson LB, Dahlin LB., Free PMC Article | 02/14/2015 |
| the activated SphK1-S1P signaling pathway in glomerular mesangial cells under diabetic conditions is closely associated with AP-1 to form a positive feedback loop. | AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose.
Huang K, Huang J, Chen C, Hao J, Wang S, Huang J, Liu P, Huang H. | 10/4/2014 |
| Small interfering RNA (siRNA) experiments demonstrated that Nrf2 and c-Jun are involved in the differential modulation of HO-1 expression in primary cultured astrocytes. | Regulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary butylhydroquinone-stimulated rat primary astrocytes.
Park JS, Kim HS. | 08/16/2014 |
| The present study investigated whether NPY Y1 receptor (Y1R) participated in activator protein-1 (AP-1)-mediated feeding. | The neuropeptide Y Y1 receptor knockdown modulates activator protein 1-involved feeding behavior in amphetamine-treated rats.
Hsieh YS, Chen PN, Yu CH, Liao JM, Kuo DY., Free PMC Article | 07/19/2014 |