| Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNbeta production. | Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNβ production.
Kula A, Makuch E, Lisowska M, Reniewicz P, Lipiński T, Siednienko J. | 06/16/2023 |
| miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3. | miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3.
Li F, Li H, Li S, Lv B, Shi J, Yan H, Zhang H, He Y. | 06/19/2021 |
| Long Non-coding RNA MIAT Mediates Non-small Cell Lung Cancer Development Through Regulating the miR-128-3p/PELI3 Axis. | Long Non-coding RNA MIAT Mediates Non-small Cell Lung Cancer Development Through Regulating the miR-128-3p/PELI3 Axis.
Li F, Li H, Li S, Lv B, Shi J, Yan H, Zhang H, He Y. | 05/29/2021 |
| PELI3 gene expression in blood and ovarian cancer. | Role of a novel circulatory RNA-based biomarker panel expression in ovarian cancer.
El-Shal AS, Matboli M, Abdelaziz AM, Morsy AA, Abdelbary EH. | 07/11/2020 |
| Two protective, low-frequency, non-synonymous variants were significantly associated with a decrease in age-related macular degeneration (AMD)risk: A307V in PELI3 and N1050Y in CFH .We also identified a strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD risk (logistic regression: OR = 0.71, P = 1.8 x 10-07). | Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.
Yu Y, Wagner EK, Souied EH, Seitsonen S, Immonen IJ, Häppölä P, Raychaudhuri S, Daly MJ, Seddon JM., Free PMC Article | 07/29/2017 |
| The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response. | Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins.
Smith SM, Freeley M, Moynagh PN, Kelleher DP. | 02/18/2017 |
| Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling. | Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE., Free PMC Article | 03/26/2016 |
| Peptide PEL3 derived from the interleukin-1 receptor-associated kinase (IRAK)1-binding motif reveals a distinct phosphothreonine peptide binding preference. | The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.
Huoh YS, Ferguson KM., Free PMC Article | 09/27/2014 |
| Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation. | Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.
Yang S, Wang B, Humphries F, Jackson R, Healy ME, Bergin R, Aviello G, Hall B, McNamara D, Darby T, Quinlan A, Shanahan F, Melgar S, Fallon PG, Moynagh PN. | 11/2/2013 |
| suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity [Pellino 3b] | Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.
Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X., Free PMC Article | 01/21/2010 |
| Pellino3 is a novel upstream regulator of p38 MAPK that activates CREB in a p38-dependent manner | Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.
Butler MP, Hanly JA, Moynagh PN. | 01/21/2010 |