| These findings confirm a critical albeit differential role of T-cell lymphopenia in the susceptibility to organ-specific autoimmune responses. | Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.
Fischer HJ, Witte AK, Walter L, Gröne HJ, van den Brandt J, Reichardt HM. | 08/19/2017 |
| functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. | TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).
Chen XL, Serrano D, Ghobadi F, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S., Free PMC Article | 09/3/2016 |
| Data indicate that reduced Ca2+ influx in GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5)-deficient T-cells is associated with the inability of their mitochondria to sequester Ca2+ following capacitative entry. | GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.
Chen XL, Serrano D, Mayhue M, Wieden HJ, Stankova J, Boulay G, Ilangumaran S, Ramanathan S. | 03/30/2013 |
| results suggest that lack of the Gimap5 protein in the DR.(lyp/lyp) congenic rat was associated with impaired expression of the entire family of Gimap genes and may regulate T cell homeostasis in the peripheral lymphoid organs. | BB rat Gimap gene expression in sorted lymphoid T and B cells.
Moralejo DH, Fuller JM, Rutledge EA, Van Yserloo B, Ettinger RA, Jensen R, Osborne W, Kwitek A, Lernmark A., Free PMC Article | 12/3/2011 |
| Obesity and type 2 diabetes in the BioBreeding diabetes-resistant (BBDR) rat result in islet expansion associated with protection from T1D in female but not male BBDR(lepr-/lepr-,Gimap5-/Gimap5-) congenic rats. | Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A., Free PMC Article | 06/14/2010 |
| results show that spontaneous type 1 diabetes is controlled by at least two genetic loci 7 Mb apart on rat chromosome 4 | Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene.
Fuller JM, Bogdani M, Tupling TD, Jensen RA, Pefley R, Manavi S, Cort L, Blankenhorn EP, Mordes JP, Lernmark A, Kwitek AE., Free PMC Article | 01/21/2010 |
| GIMAP5 is an important regulator of calcium response in T lymphocytes and impaired calcium signaling might underlie spontaneous apoptosis of gimap5(lyp/lyp) T cells. | Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes.
Ilangumaran S, Forand-Boulerice M, Bousquet SM, Savard A, Rocheleau P, Chen XL, Dupuis G, Poussier P, Boulay G, Ramanathan S. | 01/21/2010 |
| Knockdown of CHOP by siRNA protected Gimap5(-/-) T cells from endoplasmic reticulum stress-induced apoptosis. | CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R., Free PMC Article | 01/21/2010 |
| These findings suggest that GIMAP5 regulates T lymphocyte survival by mechanisms that operate upstream of mitochondria. | GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment.
Keita M, Leblanc C, Andrews D, Ramanathan S. | 01/21/2010 |
| Ian4 is a tissue-specific regulator of mitochondrial integrity and is required for T cell survival | Ian4 is required for mitochondrial integrity and T cell survival.
Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R., Free PMC Article | 01/21/2010 |
| mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity | Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.
Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A., Free PMC Article | 01/21/2010 |
| in addition to their role in apoptosis, IAN family members may also play a role in regulating the T cell activation state through modulation of TCR signaling strength. | Partial activation precedes apoptotic death in T cells harboring an IAN gene mutation.
Lang JA, Kominski D, Bellgrau D, Scheinman RI. | 01/21/2010 |
| Gimap5 functions to promote both T cell survival and quiescence | Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway.
Kupfer R, Lang J, Williams-Skipp C, Nelson M, Bellgrau D, Scheinman RI. | 01/21/2010 |
| Lymphopenia in the BioBreeding rat model of spontaneous autoimmune diabetes is due to a frameshift deletion in Ian5 (immune-associated nucleotide-related gene 5) that results in truncation of a significant portion of the protein. | Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A., Free PMC Article | 01/21/2010 |
| diabetes-prone BB rat carries a frameshift mutation in Ian4; propose that Ian4 is identical to Iddm1 [Ian4] | The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.
Hornum L, Rømer J, Markholst H. | 01/21/2010 |