| ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2. | ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
Benatzy Y, Palmer MA, Lütjohann D, Ohno RI, Kampschulte N, Schebb NH, Fuhrmann DC, Snodgrass RG, Brüne B., Free PMC Article | 05/28/2024 |
| 15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection. | 15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.
Kianfar S, Salimi V, Jahangirifard A, Mirtajani SB, Vaezi MA, Yavarian J, Mokhtari-Azad T, Tavakoli-Yaraki M. | 10/11/2023 |
| Low 15-LOX-2 expression is associated with lung carcinogenesis. | Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.
Li MY, Liu LZ, Li W, Ng CSH, Liu Y, Kong AWY, Zhao Z, Wang S, Qi H, Jia H, Yang S, Du J, Long X, Ho RLK, Chak ECW, Wan IYP, Mok TSK, Underwood MJ, Gali NK, Ning Z, Chen GG., Free PMC Article | 02/15/2020 |
| ALOX15B expression and up-regulation in the functional and non-functional pituitary adenomas. | Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.
Barooni AB, Ghorbani M, Salimi V, Alimohammadi A, Khamseh ME, Akbari H, Imani M, Nourbakhsh M, Sheikhi A, Shirian FI, Ameri M, Tavakoli-Yaraki M., Free PMC Article | 01/4/2020 |
| we identified a novel role for ALOX15B, and to a lesser extent ALOX15, in cholesterol homeostasis and CCL17 production in human macrophages. | A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.
Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, Brüne B., Free PMC Article | 10/5/2019 |
| Results demonstrate the expression of ALOX15 and ALOX15B in failing as well as in donor hearts. ALOX15/B signaling may play an important role in heart disease, including heart failure. Isolated fibroblasts from all four chambers of the heart expressed ALOX15 as well as ALOX15B, and gene expression levels were further increased under hypoxia. | Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner.
Sandstedt M, Rotter Sopasakis V, Lundqvist A, Vukusic K, Oldfors A, Dellgren G, Sandstedt J, Hultén LM., Free PMC Article | 02/9/2019 |
| Ca(2+) binding induces major structural changes in the 15-lipoxygenase-2 PLAT domain. | Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange.
Droege KD, Keithly ME, Sanders CR, Armstrong RN, Thompson MK., Free PMC Article | 10/14/2017 |
| 15-LOX-2 is distributed at the plasma membrane when cells are stimulated by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of a putative membrane insertion loop. | Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS.
Bender G, Schexnaydre EE, Murphy RC, Uhlson C, Newcomer ME., Free PMC Article | 05/20/2017 |
| these results demonstrate the strict regiospecificity of h15-LOX-2 that circumscribes its role in transcellular synthesis. | Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.
Green AR, Barbour S, Horn T, Carlos J, Raskatov JA, Holman TR., Free PMC Article | 04/29/2017 |
| This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2. | Understanding the Mechanism of the Hydrogen Abstraction from Arachidonic Acid Catalyzed by the Human Enzyme 15-Lipoxygenase-2. A Quantum Mechanics/Molecular Mechanics Free Energy Simulation.
Suardíaz R, Jambrina PG, Masgrau L, González-Lafont À, Rosta E, Lluch JM. | 02/18/2017 |
| The ALOX15B gene may be associated with coronary artery disease. | Association of polymorphisms in the ALOX15B gene with coronary artery disease.
Wuest SJ, Horn T, Marti-Jaun J, Kühn H, Hersberger M. | 04/2/2016 |
| Hpoxia-induced pulmonary vascular remodeling is associated with increased levels of 15-LO-2. | Modulation of Pulmonary Vascular Remodeling in Hypoxia: Role of 15-LOX-2/15-HETE-MAPKs Pathway.
Yu X, Li T, Liu X, Yu H, Hao Z, Chen Y, Zhang C, Liu Y, Li Q, Mao M, Zhu D. | 02/13/2016 |
| ALOX15 rs11568070 polymorphisms did not discriminate for the disease or its severity. | Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid.
Setkowicz M, Mastalerz L, Gielicz A, Wojas-Pelc A, Sanak M. | 11/14/2015 |
| 15-LOX2 expression inhibits Myc-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia. | Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer.
Suraneni MV, Moore JR, Zhang D, Badeaux M, Macaluso MD, DiGiovanni J, Kusewitt D, Tang DG., Free PMC Article | 01/17/2015 |
| activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin generation | Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.
Vijil C, Hermansson C, Jeppsson A, Bergström G, Hultén LM., Free PMC Article | 01/10/2015 |
| Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension. | Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Shen T, Ma J, Zhang L, Yu X, Liu M, Hou Y, Wang Y, Ma C, Li S, Zhu D., Free PMC Article | 10/11/2014 |
| Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain. | The structure of human 15-lipoxygenase-2 with a substrate mimic.
Kobe MJ, Neau DB, Mitchell CE, Bartlett SG, Newcomer ME., Free PMC Article | 05/31/2014 |
| ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4, LPS and hypoxia. | Expression and regulation of 12/15-lipoxygenases in human primary macrophages.
Wuest SJ, Crucet M, Gemperle C, Loretz C, Hersberger M. | 04/13/2013 |
| Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups. | Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries.
Wang Y, Zhu D, An Y, Sun J, Cai L, Zheng J. | 05/19/2012 |
| The C2-domain is not essential for catalytic activity and does hardly impact reaction specificity. | The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions.
Walther M, Hofheinz K, Vogel R, Roffeis J, Kühn H. | 01/21/2012 |
| Tumor-associated macrophages isolated from RCC tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid. | Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway.
Daurkin I, Eruslanov E, Stoffs T, Perrin GQ, Algood C, Gilbert SM, Rosser CJ, Su LM, Vieweg J, Kusmartsev S. | 12/17/2011 |
| In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms. | 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.
Gertow K, Nobili E, Folkersen L, Newman JW, Pedersen TL, Ekstrand J, Swedenborg J, Kühn H, Wheelock CE, Hansson GK, Hedin U, Haeggström JZ, Gabrielsen A. | 08/13/2011 |
| White tea extract induces apoptosis via PPAR gamma and 15-lipoxygenases. | White tea extract induces apoptosis in non-small cell lung cancer cells: the role of peroxisome proliferator-activated receptor-{gamma} and 15-lipoxygenases.
Mao JT, Nie WX, Tsu IH, Jin YS, Rao JY, Lu QY, Zhang ZF, Go VL, Serio KJ., Free PMC Article | 01/1/2011 |
| Results from this study suggest a 125-bp region (-157 to -33) is critical for the 15-LOX-2 promoter activity in prostate epithelial cells and cancer cells | Downregulation of 15-lipoxygenase 2 by glucocorticoid receptor in prostate cancer cells.
Feng Y, Bai X, Yang Q, Wu H, Wang D. | 08/23/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |