| Effect of Surgery on Postoperative Levels of the Gut Homeostasis-Regulating Enzyme Intestinal Alkaline Phosphatase. | Effect of Surgery on Postoperative Levels of the Gut Homeostasis-Regulating Enzyme Intestinal Alkaline Phosphatase.
Duan R, von Ehrlich-Treuenstätt VH, Kakoschke SC, Schardey J, Wirth U, Albertsmeier M, Renz BW, Andrassy J, Bazhin AV, Hodin RA, Werner J, Ilmer M, Kühn F. | 12/28/2023 |
| The role of intestinal alkaline phosphatase in the development of necrotizing enterocolitis. | The role of intestinal alkaline phosphatase in the development of necrotizing enterocolitis.
Martins RDS, Kooi EMW, Poelstra K, Hulscher JBF. | 07/26/2023 |
| Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene. | Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.
Noda S, Yamada A, Asawa Y, Nakamura H, Matsumura T, Orimo H, Goseki-Sone M. | 09/10/2022 |
| Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway. | Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway.
Singh SB, Coffman CN, Varga MG, Carroll-Portillo A, Braun CA, Lin HC., Free PMC Article | 06/18/2022 |
| Intestinal alkaline phosphatase deficiency increases the risk of diabetes. | Intestinal alkaline phosphatase deficiency increases the risk of diabetes.
Malo J, Alam MJ, Islam S, Mottalib MA, Rocki MMH, Barmon G, Tinni SA, Barman SK, Sarker T, Khan MNI, Kaliannan K, Hasanat MA, Rahman S, Pathan MF, Khan AKA, Malo MS., Free PMC Article | 03/26/2022 |
| Role of Intestinal Alkaline Phosphatase in Innate Immunity. | Role of Intestinal Alkaline Phosphatase in Innate Immunity.
Singh SB, Lin HC., Free PMC Article | 01/22/2022 |
| A role for intestinal alkaline phosphatase in preventing liver fibrosis. | A role for intestinal alkaline phosphatase in preventing liver fibrosis.
Liu Y, Cavallaro PM, Kim BM, Liu T, Wang H, Kühn F, Adiliaghdam F, Liu E, Vasan R, Samarbafzadeh E, Farber MZ, Li J, Xu M, Mohad V, Choi M, Hodin RA., Free PMC Article | 08/7/2021 |
| Study establishes that IAP deficiency in stool is associated with ischemic heart disease (IHD), and a high level of IAP might play a protective role against IHD. | Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease.
Malo J, Alam MJ, Shahnaz M, Kaliannan K, Chandra G, Aziz T, Sarker T, Bala M, Paul R, Saha CK, Karmakar PK, Malo MS., Free PMC Article | 05/16/2020 |
| Data confirm that, in enterocytes (Caco-2 cells), 1-alpha,25-dihydroxy-vitamin-D3 up-regulates expression of 2 isoforms of IAP, alternative splicing variants. | 1-alpha,25-Dihydroxyvitamin D(3) up-regulates the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis.
Noda S, Yamada A, Nakaoka K, Goseki-Sone M. | 07/28/2018 |
| Expressions of human intestinal alkaline phosphatase and sucrase-isomaltase, which are intestinal differentiation markers, were highly enhanced in Caco-2 cells by menaquinone-4. | Menaquinone-4 (vitamin K(2)) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells.
Noda S, Yamada A, Tanabe R, Nakaoka K, Hosoi T, Goseki-Sone M. | 02/3/2018 |
| Data indicate alkaline phosphatase (AP) as the primary soluble ectonucleotidase in infants undergoing cardiopulmonary bypass and show decreased capacity to clear AMP when AP activity decreases post-bypass. | Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass.
Davidson JA, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer PE, Klawitter J., Free PMC Article | 08/5/2017 |
| Intestinal alkaline phosphatase is a major regulator of gut mucosal permeability and appears to work at least partly through improving tight junction protein levels and localization. | Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.
Liu W, Hu D, Huo H, Zhang W, Adiliaghdam F, Morrison S, Ramirez JM, Gul SS, Hamarneh SR, Hodin RA., Free PMC Article | 07/22/2017 |
| A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity | A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity.
Malo MS., Free PMC Article | 10/22/2016 |
| Review of the role of intestinal alkaline phosphatase in inflammatory diseases. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation. | Intestinal alkaline phosphatase: a summary of its role in clinical disease.
Fawley J, Gourlay DM., Free PMC Article | 09/10/2016 |
| The expression of ALPi and MUC5AC in cocultures of Caco-2 and HT29 cells developed for permeability studies is reported. | Optimization of Caco-2 and HT29 co-culture in vitro cell models for permeability studies.
Pan F, Han L, Zhang Y, Yu Y, Liu J. | 06/28/2016 |
| Data indicate that histone deacetylase inhibitors (HDACi) induce intestinal alkaline phosphatase (ALPi) in a subset of colon cancer cell lines in a Kruppel-like factor 5 (KLF5)-dependent manner. | The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.
Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM., Free PMC Article | 01/31/2015 |
| Report lowered intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease. | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.
Molnár K, Vannay A, Szebeni B, Bánki NF, Sziksz E, Cseh A, Győrffy H, Lakatos PL, Papp M, Arató A, Veres G., Free PMC Article | 11/24/2012 |
| we are the first to demonstrate the alteration of protein expression of iAP in the duodenal mucosa of children with newly diagnosed coeliac disease | Decreased mucosal expression of intestinal alkaline phosphatase in children with coeliac disease.
Molnár K, Vannay A, Sziksz E, Bánki NF, Győrffy H, Arató A, Dezsőfi A, Veres G. | 04/28/2012 |
| Mechanism of IAP action appears to be through dephosphorylation of specific bacterial components, including LPS, CpG DNA, and flagellin, and not on live bacteria. IAP likely targets these bacterially derived molecules as gut mucosal defense factor. | Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase.
Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA., Free PMC Article | 09/6/2010 |
| Suggest role for lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration. | Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.
Nakano T, Inoue I, Alpers DH, Akiba Y, Katayama S, Shinozaki R, Kaunitz JD, Ohshima S, Akita M, Takahashi S, Koyama I, Matsushita M, Komoda T., Free PMC Article | 01/21/2010 |
| Cathepsin C propeptide interacts with intestinal alkaline phosphatase (IAP) and heat shock cognate protein 70. The propeptide of cathepsin C may stimulate the sorting to the lysosome contributing to the degradation of IAP in Caco-2 cells. | Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells.
Hirasaka K, Tokuoka K, Nakao R, Yamada C, Oarada M, Imagawa T, Ishidoh K, Okumura Y, Kishi K, Nikawa T. | 01/21/2010 |
| has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier. IAP expression and function are lost with starvation and maintained by enteral feeding | Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.
Goldberg RF, Austen WG Jr, Zhang X, Munene G, Mostafa G, Biswas S, McCormack M, Eberlin KR, Nguyen JT, Tatlidede HS, Warren HS, Narisawa S, Millán JL, Hodin RA., Free PMC Article | 01/21/2010 |
| Crohn's disease increases the alkaline phosphatase activity in the intestine. Use histochemistry to differentiate Crohn's disease/ulcerative colitis. | A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.
Torres MI, Lorite P, López-Casado MA, Ríos A. | 01/21/2010 |
| intestinal alkaline transactivation by Kruppel-like factor-4 is likely mediated through a critical region located within the proximal IAP promoter region | Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.
Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, Abedrapo MA, Chen X, Yang VW, Hodin RA. | 01/21/2010 |
| the structural differences in human AP isoforms are demonstrated through models | Structural evidence of functional divergence in human alkaline phosphatases.
Le Du MH, Millan JL. | 01/21/2010 |