| Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers. | Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers.
Yamaguchi M, Kimura M, Ohno T, Nakahara N, Akiyama N, Takemori S, Yagi N., Free PMC Article | 02/13/2021 |
| The Liver and Kidneys mediate clearance of cardiac troponin in the rat. | The Liver and Kidneys mediate clearance of cardiac troponin in the rat.
Muslimovic A, Fridén V, Tenstad O, Starnberg K, Nyström S, Wesén E, Esbjörner EK, Granholm K, Lindahl B, Hammarsten O., Free PMC Article | 12/5/2020 |
| Replacement of the functionally corresponding N-terminal end portion of rat fast skeletal cardiac muscle (RfsTnT) into cardiac muscle troponin T (RcTnT), the observed functional differences associate with a sequence variation. | The tropomyosin binding region of cardiac troponin T modulates crossbridge recruitment dynamics in rat cardiac muscle fibers.
Gollapudi SK, Gallon CE, Chandra M., Free PMC Article | 06/29/2013 |
| L48Q cTnC reduced crossbridge dependence of thin filament activation in cardiac muscle and changes in Ca(2+) sensitivity of force in response to changes in sarcomere length are at least partially dependent on properties of thin filament troponin. | Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.
Korte FS, Feest ER, Razumova MV, Tu AY, Regnier M., Free PMC Article | 12/22/2012 |
| cTnC, cTnI, cTnT and cTm are not only present in myofilaments of ventricular cardiomyocytes in culture but are also within their nuclei; significantly, these four proteins appear between days 3 and 5 in both myofilaments and nuclei | Nuclear cardiac troponin and tropomyosin are expressed early in cardiac differentiation of rat mesenchymal stem cells.
Asumda FZ, Chase PB. | 09/29/2012 |
| Early single cTnT measurement correlates with infarct size in rats, and a cutoff value of 5.1 mug/l provides good sensitivity and specificity to predict congestive heart failure with secondary pulmonary hypertension. | Single measurement of troponin T for early prediction of infarct size, congestive heart failure, and pulmonary hypertension in an animal model of myocardial infarction.
Jiang BH, Nguyen QT, Tardif JC, Shi Y, Dupuis J. | 09/10/2011 |
| The time course of cTnT elevation was temporally associated with evidence of increased lipid peroxidation in the rat heart. | Temporal association of elevations in serum cardiac troponin T and myocardial oxidative stress after prolonged exercise in rats.
Nie J, Close G, George KP, Tong TK, Shi Q. | 03/26/2011 |
| a novel role for cTnT as a dual-specificity sarcomeric A-kinase anchoring protein | Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.
Sumandea CA, Garcia-Cazarin ML, Bozio CH, Sievert GA, Balke CW, Sumandea MP., Free PMC Article | 02/5/2011 |
| Studies show that the rat Tnnt2-rtTA;TetO-Cre mice transgenic line a valuable genetic tool for analysis of spatiotemporal gene function and cardiomyocyte lineage tracing during developmental and postnatal period. | Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse.
Wu B, Zhou B, Wang Y, Cheng HL, Hang CT, Pu WT, Chang CP, Zhou B., Free PMC Article | 05/31/2010 |
| Study demonstrate profound energetic alterations in DEL-TNT hearts, supporting the notion that inefficient cellular ATP utilization contributes to the pathogenesis of HCM. | Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy.
Luedde M, Flögel U, Knorr M, Grundt C, Hippe HJ, Brors B, Frank D, Haselmann U, Antony C, Voelkers M, Schrader J, Most P, Lemmer B, Katus HA, Frey N. | 01/21/2010 |
| Mdetabolic inhibition of cardiomyocytes induces a parallel release of intact Tnnt3 and its degradation products, starting only after onset of irreversible cardiomyocyte damage. | Release kinetics of intact and degraded troponin I and T after irreversible cell damage.
Hessel MH, Michielsen EC, Atsma DE, Schalij MJ, van der Valk EJ, Bax WH, Hermens WT, van Dieijen-Visser MP, van der Laarse A. | 01/21/2010 |
| Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T. | Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T.
Lu XY, Chen L, Cai XL, Yang HT. | 01/21/2010 |
| The mu-calpain-mediated proteolytic modification of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions. | Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage.
Zhang Z, Biesiadecki BJ, Jin JP., Free PMC Article | 01/21/2010 |