| Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells. | Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.
Yang N, Dong B, Song Y, Li Y, Kou L, Qin Q. | 11/5/2022 |
| Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens. | Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens.
Rodríguez-Rivera C, González-Martín C, Fernández-Millán E, Álvarez C, Escrivá F, Alguacil LF. | 10/1/2022 |
| Clusterin enhances cell survival by suppressing neuronal nitric-oxide synthase expression in the rhodopsin S334ter-line3 retinitis pigmentosa model. | Clusterin enhances cell survival by suppressing neuronal nitric-oxide synthase expression in the rhodopsin S334ter-line3 retinitis pigmentosa model.
Vargas A, Yamamoto KL, Craft CM, Lee EJ. | 03/19/2022 |
| Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis. | Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.
Tian Y, Xiao YH, Geng T, Sun C, Gu J, Tang KF, Liu B, Liu YM, Sun F. | 09/4/2021 |
| Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury. | Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury.
Das Gupta S, Lipponen A, Paldanius KMA, Puhakka N, Pitkänen A., Free PMC Article | 11/21/2020 |
| increased CLU expression and secretion after myocardial infarction is, in part, due to a defect of ubiquitin proteasome system and macroautophagy activities in the heart. | Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity.
Turkieh A, Porouchani S, Beseme O, Chwastyniak M, Amouyel P, Lamblin N, Balligand JL, Bauters C, Pinet F., Free PMC Article | 08/1/2020 |
| ApoJ confers cytoprotection to Neonatal rat ventricular cells against Oxidized low-density lipoprotein cytotoxicity through the reactive oxygen species-CaMKII pathways. | Apolipoprotein-J blocks increased cell injury elicited by ox-LDL via inhibiting ROS-CaMKII pathway.
Ma Y, Gong Z, Nan K, Qi S, Chen Y, Ding C, Wang D, Ru L., Free PMC Article | 11/23/2019 |
| clusterin might be involved in the formation of tubular complexes and parenchymal regeneration during rat pancreatitis | Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats.
Park JW, Nam KT, Shin JH, Kim IY, Choi KM, Roh KJ, Oh SH, Yun YM, Suh JG, Oh YS, Yoon YS, Seong JK., Free PMC Article | 12/22/2018 |
| Results showed long-term alteration in protein levels of cPLA2 and clusterin, as well as their downstream autophagy markers Beclin-1, LC3, p62 and Cathepsin-E that is in parallel with cognitive deficits and hippocampal mossy fiber sprouting following recurrent prolonged neonatal seizures, which were restored by chronic ketogenic diet treatment | Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures.
Ni H, Zhao DJ, Tian T. | 10/29/2016 |
| Results suggest that an increase in the secretion of clusterin by Sertoli cells protects the testes from heat stress-induced injury. | Clusterin produced by Sertoli cells inhibits heat stress-induced apoptosis in the rat testis.
Matsushita K, Miyake H, Chiba K, Fujisawa M. | 10/22/2016 |
| Clusterin/Akt signaling pathway is involved in GATA-4 mediated cytoprotection against hypoxia stress. | Clusterin/Akt Up-Regulation Is Critical for GATA-4 Mediated Cytoprotection of Mesenchymal Stem Cells against Ischemia Injury.
Yu B, Yang Y, Liu H, Gong M, Millard RW, Wang YG, Ashraf M, Xu M., Free PMC Article | 08/6/2016 |
| ApoJ serves as a cytoprotective protein in neonatal rat ventricular cells against cytotoxicity of AngII through the PI3K-Akt-ROS and MAPK/ NF-kappaB pathways. | Apolipoprotein-J prevents angiotensin II-induced apoptosis in neonatal rat ventricular cells.
Ma Y, Kong L, Nan K, Qi S, Ru L, Ding C, Wang D., Free PMC Article | 07/16/2016 |
| rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus | Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals.
Tian T, Ni H, Sun BL. | 06/4/2016 |
| Overexpression of clusterin in proximal tubular epithelial cells decreased the levels of Ang II-stimulated fibrotic markers and AT1R. | Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.
Jung GS, Jeon JH, Jung YA, Choi YK, Kim HS, Kim JG, Park KG, Kim MK, Lee IK., Free PMC Article | 11/14/2015 |
| Following restraint stress, hypothalamic and pituitary clusterin expression levels are augmented. | Hypothalamic and pituitary clusterin modulates neurohormonal responses to stress.
Shin MS, Chang H, Namkoong C, Kang GM, Kim HK, Gil SY, Yu JH, Park KH, Kim MS. | 08/30/2014 |
| Exendin-4 treatment induces new beta cell clusters via up-regulation of clusterin, which might be effective on beta-cell proliferation and neogenesis. | The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats.
Kaya-Dagistanli F, Ozturk M. | 10/19/2013 |
| Nulear clusterin plays a pro-apoptotic role in ethanol-induced cell death in the developing brain. | Nuclear clusterin is associated with neuronal apoptosis in the developing rat brain upon ethanol exposure.
Kim N, Han JY, Roh GS, Kim HJ, Kang SS, Cho GJ, Park JY, Choi WS. | 08/25/2012 |
| Cox-2 induces clusterin in a 15d-PGJ(2)-dependent manner. | Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism.
Gates D, Dollin K, Connolly R, Young I, Powell L, McEneny J, Gleave M, McGinty A. | 04/14/2012 |
| Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. | Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.
Materia S, Cater MA, Klomp LW, Mercer JF, La Fontaine S., Free PMC Article | 03/17/2012 |
| attenuates renal fibrosis in obstructive nephropathy | Clusterin attenuates the development of renal fibrosis.
Jung GS, Kim MK, Jung YA, Kim HS, Park IS, Min BH, Lee KU, Kim JG, Park KG, Lee IK., Free PMC Article | 03/10/2012 |
| The results suggested that clusterin may contribute to gastrin's growth-promoting effect on the oxyntic mucosa. | Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats.
Fjeldbo CS, Bakke I, Erlandsen SE, Holmseth J, Lægreid A, Sandvik AK, Thommesen L, Bruland T. | 02/18/2012 |
| bisphenol A upregulated clusterin expression in atrophic prostate epithelial cells and induced lipid peroxidation and DNA fragmentation in spermatozoa. | Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells.
De Flora S, Micale RT, La Maestra S, Izzotti A, D'Agostini F, Camoirano A, Davoli SA, Troglio MG, Rizzi F, Davalli P, Bettuzzi S. | 12/10/2011 |
| clusterin is an important mediator of neural precursor cell-derived neuronal survival and differentiation | Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells.
Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Chandran S, Caldwell MA., Free PMC Article | 09/24/2011 |
| The chaperone clusterin mediates systemic clearance of misfolded extracellular proteins | Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Wyatt AR, Yerbury JJ, Berghofer P, Greguric I, Katsifis A, Dobson CM, Wilson MR., Free PMC Article | 05/4/2011 |
| The chaperone clusterin inhibits aggregation and precipitation of major human plasma proteins | Identification of human plasma proteins as major clients for the extracellular chaperone clusterin.
Wyatt AR, Wilson MR., Free PMC Article | 05/4/2011 |