| WTAP-mediated m[6]A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis. | WTAP-mediated m(6)A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis.
An X, Wang R, Lv Z, Wu W, Sun Z, Wu R, Yan W, Jiang Q, Xu X., Free PMC Article | 02/12/2024 |
| FRZB is Regulated by the Transcription Factor EGR1 and Inhibits the Growth and Invasion of Triple-Negative Breast Cancer Cells by Regulating the JAK/STAT3 Pathway. | FRZB is Regulated by the Transcription Factor EGR1 and Inhibits the Growth and Invasion of Triple-Negative Breast Cancer Cells by Regulating the JAK/STAT3 Pathway.
Liu H, Mei Y, Ma X, Zhang X, Nie W. | 10/8/2022 |
| Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis. | Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis.
Tuerlings M, van Hoolwerff M, van Bokkum JM, Suchiman HED, Lakenberg N, Broekhuis D, Nelissen RGHH, Ramos YFM, Mei H, Cats D, Coutinho de Almeida R, Meulenbelt I., Free PMC Article | 07/16/2022 |
| The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity. | The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity.
Huang X, Zhong L, van Helvoort E, Lafeber F, Mastbergen S, Hendriks J, Post JN, Karperien M., Free PMC Article | 01/29/2022 |
| FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity. | FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity.
Oh CK, Ko Y, Park JJ, Heo HJ, Kang J, Kwon EJ, Kang JW, Lee Y, Myung K, Kang JM, Ko DS, Kim YH., Free PMC Article | 12/11/2021 |
| Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip. | Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.
Xu R, Zhang F, Lu J, Wang K, Pan P, Sun Y, Zhang Y., Free PMC Article | 08/7/2021 |
| Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels. | Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels.
Casas-Fraile L, Cornelis FM, Costamagna D, Rico A, Duelen R, Sampaolesi MM, López de Munain A, Lories RJ, Sáenz A., Free PMC Article | 07/31/2021 |
| Our data suggest there might be differential genetic influence on skeletal fluorosis risk in Kazakh and Tibetan participants and that this difference might be modified by tea fluoride intake. | FRZB1 rs2242070 polymorphisms is associated with brick tea type skeletal fluorosis in Kazakhs, but not in Tibetans, China.
Yang Y, Zhao Q, Liu Y, Liu X, Chu Y, Yan H, Fan Y, Huo S, Wang L, Lou Q, Guo N, Sun D, Gao Y. | 10/12/2019 |
| active involvement in placental development and important role in pathology of pregnancy | Negative regulators of Wnt signaling pathway SFRP1 and SFRP3 expression in preterm and term pathologic placentas.
Zmijanac Partl J, Karin V, Skrtic A, Nikuseva-Martic T, Serman A, Mlinarec J, Curkovic-Perica M, Vranic S, Serman L. | 12/22/2018 |
| Systemic and local levels of sFRP3 protein are downregulated in osteosarcoma. | Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients.
Bravo D, Salduz A, Shogren KL, Okuno MN, Herrick JL, Okuno SH, Galindo M, van Wijnen AJ, Yaszemski MJ, Maran A., Free PMC Article | 08/25/2018 |
| we observed that FRZB regulates integrin beta1D expression, its silencing increasing integrin beta1D expression to levels similar to those in controls. | FRZB and melusin, overexpressed in LGMD2A, regulate integrin β1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.
Jaka O, Casas-Fraile L, Azpitarte M, Aiastui A, López de Munain A, Sáenz A. | 04/7/2018 |
| endogenous expression of the WNT antagonists DKK1 and FRZB is necessary for multiple steps during chondrogenesis | Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells.
Zhong L, Huang X, Rodrigues ED, Leijten JC, Verrips T, El Khattabi M, Karperien M, Post JN., Free PMC Article | 09/16/2017 |
| this study shows that sFRP3 regulates fibroblast-like synociocyte transformation | sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context.
Elhaj Mahmoud D, Sassi N, Drissi G, Barsaoui M, Zitouna K, Sahli H, Kallel-Sellami M, Kanoun L, Cheour E, Laadhar L. | 04/8/2017 |
| This may suggest that SFRP3 acts as an agonist of Wnt signaling and promotes invasive behavior. | Expression patterns of Wnt signaling component, secreted frizzled‑related protein 3 in astrocytoma and glioblastoma.
Pećina-Šlaus N, Kafka A, Varošanec AM, Marković L, Krsnik Ž, Njirić N, Mrak G., Free PMC Article | 02/25/2017 |
| The secreted frizzled-related protein and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors. | The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors.
Fabijanovic D, Zunic I, Martic TN, Skenderi F, Serman L, Vranic S. | 01/28/2017 |
| FRZB expression was up-regulated in hepatocellular carcinoma bone metastasis tissue, which suggested that FRZB might play a key role in the HCC bone metastasis. | FRZB up-regulated in hepatocellular carcinoma bone metastasis.
Huang J, Hu W, Lin X, Wang X, Jin K., Free PMC Article | 10/22/2016 |
| Positive expression of FRZB was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis. | FRZB up-regulation is correlated with hepatic metastasis and poor prognosis in colon carcinoma patients with hepatic metastasis.
Shen Y, Zhang F, Lan H, Chen K, Zhang Q, Xie G, Teng L, Jin K., Free PMC Article | 10/1/2016 |
| Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma | Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.
Kephart JJ, Tiller RG, Crose LE, Slemmons KK, Chen PH, Hinson AR, Bentley RC, Chi JT, Linardic CM., Free PMC Article | 08/20/2016 |
| Intermediate SFRP3 levels are associated with better survival and fewer cardiovascular events than low or high SFRP3 levels, independently of conventional risk factors, in older patients with chronic systolic Heart Failure of ischemic origin. | Secreted Frizzled Related Protein 3 in Chronic Heart Failure: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Askevold ET, Gullestad L, Nymo S, Kjekshus J, Yndestad A, Latini R, Cleland JG, McMurray JJ, Aukrust P, Ueland T., Free PMC Article | 05/25/2016 |
| Intermediate levels of sFRP3 were a predictor of all-cause mortality and re-hospitalization in acute coronary syndromes. | Secreted Frizzled-Related Protein 3 (sFRP3) in acute coronary syndromes.
Ueland T, Caidahl K, Askevold ET, Karlsson T, Hartford M, Aukrust P. | 03/5/2016 |
| Data suggest secreted FRP3 (frizzled related protein-3) interacts with ADAM17 (A disintegrin/metalloprotease 17) substrate IL6R (interleukin-6 receptor) release; this interaction is down-regulated in osteoarthritis due to rare double variant in FRP3. | Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.
Oldefest M, Düsterhöft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I. | 10/10/2015 |
| study indicates that increased expression of both SFRP1 and SFRP3 may contribute to the pathogenesis of IUGR placental dysfunction, whereas the loss of these proteins may be involved in the development of human trophoblastic tumors. | Immunohistochemical expression of SFRP1 and SFRP3 proteins in normal and malignant reproductive tissues of rats and humans.
Partl JZ, Fabijanovic D, Skrtic A, Vranic S, Martic TN, Serman L. | 06/20/2015 |
| These data indicate an important role of methylation-induced gene silencing of the sFRP gene family in human GBM. | Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme.
Schiefer L, Visweswaran M, Perumal V, Arfuso F, Groth D, Newsholme P, Warrier S, Dharmarajan A. | 04/25/2015 |
| Our results suggest that the sFRP3 c.970C>G and sFRP4 c.958C>A polymorphisms may be genetic factors associated with the prevalence of osteoporosis at the femoral neck in postmenopausal Korean women. | Association between polymorphisms in sclerostin, dickkopfs and secreted frizzled-related protein genes and bone mineral density in postmenopausal Korean women.
Lee DO, Kim H, Ku SY, Kim SH, Kim JG. | 01/24/2015 |
| Promoter hypermethylation of SFRP3 is a common event hepatocellular carcinoma. | Promoter methylation of SFRP3 is frequent in hepatocellular carcinoma.
Lin YW, Shih YL, Lien GS, Suk FM, Hsieh CB, Yan MD., Free PMC Article | 01/24/2015 |