| The HDAC Inhibitor Butyrate Impairs beta Cell Function and Activates the Disallowed Gene Hexokinase I. | The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I.
Bridgeman S, Ellison G, Newsholme P, Mamotte C., Free PMC Article | 01/15/2022 |
| Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina. | Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina.
Ramírez-Pérez G, Sánchez-Chávez G, Salceda R. | 06/12/2021 |
| alpha-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease. | α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.
Dehghani Z, Meratan AA, Saboury AA, Nemat-Gorgani M. | 08/22/2020 |
| specific roles of mitochondria bound-HK and SDH on the metabolism of each brain region, are reported. | Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in H(2)O(2) Depuration.
Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A. | 02/9/2019 |
| results suggest that phenylpyruvic acid is the cause of the reduction of glucose consumption by decreasing hexokinase activity. Therefore, production of ATP declines in brain cells. | In-silico and in-vitro investigation on the phenylalanine metabolites' interactions with hexokinase of Rat's brain mitochondria.
Ziamajidi N, Jamshidi S, Ehsani-Zonouz A. | 12/9/2017 |
| There was an increase in hexokinase1 expression in right ventricle from pulmonary hypertension rats. | Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension.
Zhang WH, Qiu MH, Wang XJ, Sun K, Zheng Y, Jing ZC., Free PMC Article | 04/18/2015 |
| Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls. | The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
Martins-de-Souza D, Alsaif M, Ernst A, Harris LW, Aerts N, Lenaerts I, Peeters PJ, Amess B, Rahmoune H, Bahn S, Guest PC., Free PMC Article | 03/2/2013 |
| The results show that Hk1 and GLUT3 may play a role in the pathophysiology of ketamine-induced behavioral abnormalities. | The expression of genes involved in glucose metabolism is affected by N-methyl-D-aspartate receptor antagonism: a putative link between metabolism and an animal model of psychosis.
Iasevoli F, Latte G, Avvisati L, Sarappa C, Aloj L, de Bartolomeis A. | 11/24/2012 |
| The activities of HK in all subcellular fractions are enhanced in response to myocardial infarction | Enhanced activity and subcellular redistribution of myocardial hexokinase after acute myocardial infarction.
Yeih DF, Yeh HI, Lin LY, Tsay YG, Chiang FT, Tseng CD, Tseng YZ. | 09/17/2011 |
| Abeta-induced cellular redistribution and inactivation of neuronal HKI play important roles in oxidative stress and neurodegeneration in Alzheimer's disease | Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.
Saraiva LM, Seixas da Silva GS, Galina A, da-Silva WS, Klein WL, Ferreira ST, De Felice FG., Free PMC Article | 07/9/2011 |
| HKI remains strongly bound to mitochondria, whereas HKII translocates between mitochondria and the cytosol in response to glucose, G-6-P and Akt, but not ATP. | Subcellular localization of hexokinases I and II directs the metabolic fate of glucose.
John S, Weiss JN, Ribalet B., Free PMC Article | 07/9/2011 |
| Ischemic preconditioning is associated with 1) a biphasic response of increased mitochondrial HK activity before and after ischemia, 2) decreased cytosolic HK activity during ischemia, and 3) cellular redistribution of HKII but not HKI. | Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion.
Gürel E, Smeele KM, Eerbeek O, Koeman A, Demirci C, Hollmann MW, Zuurbier CJ. | 01/21/2010 |
| The results support a key role for hexokinase activity and/or localization to the mitochondria in the regulation of neurite outgrowth in cultured adult sensory neurons. | Blockade of hexokinase activity and binding to mitochondria inhibits neurite outgrowth in cultured adult rat sensory neurons.
Wang Z, Gardiner NJ, Fernyhough P. | 01/21/2010 |
| Between these two strategies to activate glycogen deposition in the absence of GK, embryonic livers choose to express massive levels of HKI and HKII. | Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.
Cifuentes D, Martínez-Pons C, García-Rocha M, Galina A, Ribas de Pouplana L, Guinovart JJ. | 01/21/2010 |
| Cmplex effects of diabetes on hexokinase I expression in the DRG may be due to glucose-driven up-regulation of expression or the result of impaired axonal transport and perikaryal accumulation in the large neuron sub-population. | Expression of hexokinase isoforms in the dorsal root ganglion of the adult rat and effect of experimental diabetes.
Gardiner NJ, Wang Z, Luke C, Gott A, Price SA, Fernyhough P. | 01/21/2010 |
| results imply that the high hexokinase-binding capability of porin-enriched mitochondria was due to a quantitative difference in binding sites | Involvement of porin N,N-dicyclohexylcarbodiimide-reactive domain in hexokinase binding to the outer mitochondrial membrane.
Al Jamal JA. | 01/21/2010 |
| These events are isoform specific, suggesting that HK I and HK II are independently regulated and implying that they perform different roles in cardiac glucose regulation. | A reevaluation of the roles of hexokinase I and II in the heart.
Southworth R, Davey KA, Warley A, Garlick PB. | 01/21/2010 |
| the Hexokinase-mitochondria interaction mediated by Akt has a role in inhibiting apoptosis but does not require Bax and Bak | Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.
Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N. | 01/21/2010 |
| Findings suggest the presence of hexokinase I in detergent-resistant membrane domains of spermatogenic cells, and support a role for caveolae in relation to glucose uptake and glucose phosphorylation. | Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells.
Rauch MC, Ocampo ME, Bohle J, Amthauer R, Yáñez AJ, Rodríguez-Gil JE, Slebe JC, Reyes JG, Concha II. | 01/21/2010 |