| Data suggest that CYP17A1 and aromatase/Cyp19a1 are induced in hippocampus by the environmental pollutant/retinoid X receptor agonist tributyltin; thus, tributyltin appears to stimulate estradiol biosynthesis. | Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices.
Munetsuna E, Hattori M, Yamazaki T. | 06/20/2015 |
| Data from a rat model of polycystic ovary syndrome suggest that hyperandrogenism develops and this may partially up-regulate expression of steroidogenic enzymes (CYP17 and P450scc [cholesterol side-chain cleavage enzyme]) in ovarian tissue. | Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS.
Li H, Chen Y, Yan LY, Qiao J. | 06/15/2013 |
| these data demonstrate the occurrence of P450C(17) in the deep cerebellar nuclei of the rat | Cytochrome P450 17α-hydroxylase/C(17,20)-lyase immunoreactivity and molecular expression in the cerebellar nuclei of adult male rats.
Manca P, Caria MA, Blasi J, Martín-Satué M, Mameli O. | 04/20/2013 |
| Data demonstrate, for the first time, the presence and anatomical distribution of P450C(17) in the vestibular nuclei. | Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome P450 17α-hydroxylase /C(17,20)-lyase in the vestibular nuclei of adult male rats.
Manca P, Mulliri G, Burrai GP, Pirino S, Mameli O. | 08/27/2011 |
| Dibromoacetic acid can directly target rat Leydig cells and downregulate testicular CYP17 expression with a resulting decreased testicular testosterone production. | Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats.
Carr TL, Ciurlionis R, Milicic I, Whitney K, Liguori MJ, Warder SE, Strakhova MI, Blomme EA. | 08/20/2011 |
| immunolocalization of 3beta-hydroxysteroid dehydrogense, cytochrome P450c17 and androgen receptor were investigated in rat cumuli oophori of late pre-ovulatory follicles and in post-ovulatory COCs bearing fertilized oocytes | Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats.
Szołtys M, Słomczyńska M, Knapczyk-Stwora K, Durlej M, Lechowska A, Starowicz A. | 02/26/2011 |
| Results suggest that PCB126 may affect testicular steroidogenesis by downregulating P450(17alpha), P450(scc) and have inhibitory effect on the testicular functions. | Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc).
Han DY, Kang SR, Park OS, Cho JH, Won CK, Park HS, Park KI, Kim EH, Kim GS. | 09/13/2010 |
| The expression of the mouse CYP17A1 gene is epigenetically controlled. | Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents.
Missaghian E, Kempná P, Dick B, Hirsch A, Alikhani-Koupaei R, Jégou B, Mullis PE, Frey BM, Flück CE. | 01/21/2010 |
| GDF-9 plays an important role in promoting preantral follicle growth by up-regulating follicular androgen biosynthesis. GDF-9 is essential for CYP17A1 expression during follicular development from the preantral to the early antral stage. | Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis.
Orisaka M, Jiang JY, Orisaka S, Kotsuji F, Tsang BK. | 01/21/2010 |
| Cyp17a1 in beta-cells of rat pancreas and its local steroidogenesis are reported. | Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis.
Ogishima T, Mitani F, Suematsu M. | 01/21/2010 |
| 17beta-estradiol is synthesized by P45017alpha and P450 aromatase localized in hippocampal neurons from endogenous cholesterol | Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.
Hojo Y, Hattori TA, Enami T, Furukawa A, Suzuki K, Ishii HT, Mukai H, Morrison JH, Janssen WG, Kominami S, Harada N, Kimoto T, Kawato S., Free PMC Article | 01/21/2010 |
| CYP17 is expressed in rat kidney throughout the life-span and has a role in autonomous hormonal steroidogenesis | Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span.
Dalla Valle L, Toffolo V, Vianello S, Belvedere P, Colombo L. | 01/21/2010 |