| SRY directs a previously unrecognized male-specific mechanism of dopaminergic neuron cell death. | Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson's disease.
Lee J, Pinares-Garcia P, Loke H, Ham S, Vilain E, Harley VR., Free PMC Article | 03/28/2020 |
| Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis. | Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
Racca JD, Chen YS, Yang Y, Phillips NB, Weiss MA., Free PMC Article | 05/27/2017 |
| These results suggest that SRY regulation of the renin-angiotensin system is partially shared with its X-chromosome homolog SOX3. | Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.
Araujo FC, Milsted A, Watanabe IK, Del Puerto HL, Santos RA, Lazar J, Reis FM, Prokop JW., Free PMC Article | 01/30/2016 |
| Data show that Sry is involved in male-specific malignant conversion of rodent hepatocellular carcinoma via Sgf29 upregulation. | The male-specific factor Sry harbors an oncogenic function.
Murakami S, Chishima S, Uemoto H, Sakamoto E, Sato T, Kurabe N, Kawasaki Y, Shibata T, Akiyama H, Tashiro F. | 07/26/2014 |
| Data suggest that Sry and Tcf21 (transcription factor 21) induce initial stages of embryonic Sertoli cell differentiation; Scx (scleraxis) induces later stages. This cascade--Sry>Tcf21>Scx--appears to promote subsequent sex differentiation. | SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats.
Bhandari RK, Schinke EN, Haque MM, Sadler-Riggleman I, Skinner MK., Free PMC Article | 05/18/2013 |
| The specific DNA sequence binding site motifs for both SRY and SOX9 were identified. | Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9.
Bhandari RK, Haque MM, Skinner MK., Free PMC Article | 03/16/2013 |
| Observations suggest that SRY physically interacts with the Ntf3 promoter during male sex determination to coordinate cell migration in the testis to form testis cords. | SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in rats.
Clement TM, Bhandari RK, Sadler-Riggleman I, Skinner MK., Free PMC Article | 08/4/2012 |
| The current study identifies one of the first direct downstream targets of the male sex determining factor SRY as the basic-helix-loop-helix (bHLH) transcription factor TCF21. | Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY.
Bhandari RK, Sadler-Riggleman I, Clement TM, Skinner MK., Free PMC Article | 10/1/2011 |
| These actions of Sry could result in increased blood pressure in males and contribute to sex differences in blood pressure. | Regulation of multiple renin-angiotensin system genes by Sry.
Milsted A, Underwood AC, Dunmire J, DelPuerto HL, Martins AS, Ely DL, Turner ME., Free PMC Article | 03/15/2010 |
| The Sry loci is the hypertensive component of the SHR Y chromosome. | Which Sry locus is the hypertensive Y chromosome locus?
Turner ME, Farkas J, Dunmire J, Ely D, Milsted A. | 01/21/2010 |
| Total Sry transcript expression, analyzed by real-time PCR, showed significantly higher levels of Sry in testis than adrenal gland | Genomic and expression analysis of multiple Sry loci from a single Rattus norvegicus Y chromosome.
Turner ME, Martin C, Martins AS, Dunmire J, Farkas J, Ely DL, Milsted A., Free PMC Article | 01/21/2010 |
| Sry is specifically expressed in the substantia nigra of the adult male rodent in tyrosine hydroxylase-expressing neurons. | Direct regulation of adult brain function by the male-specific factor SRY.
Dewing P, Chiang CW, Sinchak K, Sim H, Fernagut PO, Kelly S, Chesselet MF, Micevych PE, Albrecht KH, Harley VR, Vilain E. | 01/21/2010 |