| Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction. | Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction.
Rashid FN, Clayton ZE, Ogawa M, Perdomo J, Hume RD, Kizana E, Chong JJH. | 10/23/2021 |
| an Ntv-a transgenic rat colony was established and used to study glial brain tumors driven by two well-characterized oncogenic gene transformations, PDGFA overexpression and p53 depletion. Combined PDGFA and p53 alterations resulted in large, heterogeneous tumors in all affected animals | Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.
Connolly NP, Stokum JA, Schneider CS, Ozawa T, Xu S, Galisteo R, Castellani RJ, Kim AJ, Simard JM, Winkles JA, Holland EC, Woodworth GF., Free PMC Article | 09/2/2017 |
| Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation. | Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.
Rintala JM, Savikko J, Palin N, Rintala SE, Koskinen PK, von Willebrand E. | 04/23/2016 |
| expression altered in experimental Necrotizing enterocolitis | Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis.
Shepherd JA, Stamper E, Matheson PJ, Galganski L, Garrison RN, Madden K, Downard CD. | 12/5/2015 |
| PDGF regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1. | Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.
Ha JM, Yun SJ, Kim YW, Jin SY, Lee HS, Song SH, Shin HK, Bae SS. | 10/3/2015 |
| Replacing heregulin, PDGF-AA and bFGF with T3 for 6 days resulted in repression of O4, O1, Olig2 and PDGFR-a | Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine.
Abbaszadeh HA, Tiraihi T, Delshad A, Saghedizadeh M, Taheri T, Kazemi H, Hassoun HK. | 07/25/2015 |
| observations indicated that PDGF can contribute to the development of cardiac interstitial fibrosis in the noninfarcted myocardium, but does not alter scar formation in the infarcted myocardium. | Platelet-derived growth factor blockade on cardiac remodeling following infarction.
Liu C, Zhao W, Meng W, Zhao T, Chen Y, Ahokas RA, Liu H, Sun Y. | 07/4/2015 |
| We detected the expression and levels of PDGF-AA, bFGF and IGF-1 in neuroblastoma cells and in conditioned media which stimulated proliferation of oligodendrocyte precursor cells. | PDGF-AA and bFGF mediate B104CM-induced proliferation of oligodendrocyte precursor cells.
Hu JG, Wu XJ, Feng YF, Xi GM, Wang ZH, Zhou JS, Lü HZ. | 03/9/2013 |
| PDGF-AA contained in B104 neuroblastoma cells is a key regulating molecule that instructs oligodendrocyte differentiation from embryonic stem cells through activation of Erk, PI3K, and p38 signal pathway in vitro. | PDGF-AA mediates B104CM-induced oligodendrocyte precursor cell differentiation of embryonic neural stem cells through Erk, PI3K, and p38 signaling.
Hu JG, Wang YX, Wang HJ, Bao MS, Wang ZH, Ge X, Wang FC, Zhou JS, Lü HZ. | 03/2/2013 |
| Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs | Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
Luo Y, Zhang M, Zhang J, Zhang J, Chen C, Chen YE, Xiong JW, Zhu X., Free PMC Article | 12/3/2011 |
| Paraquat-treated rats showed enhanced gene expression of growth factors such as platelet-derived growth factor-A and insulin-like growth factor-1 at 21 days and transforming growth factor-beta 1 at 14 days. | Role of growth factors in acute lung injury induced by paraquat in a rat model.
Xiangdong Jian, Ming Li, Yijing Zhang, Yanjun Ruan, Guangran Guo, Hong Sui, Yuanchao Zhang. | 09/10/2011 |
| The influence of physical exercise on the generation of PDGF-AA, in adipose tissue | The influence of physical exercise on the generation of TGF-β1, PDGF-AA, and VEGF-A in adipose tissue.
Czarkowska-Paczek B, Zendzian-Piotrowska M, Bartlomiejczyk I, Przybylski J, Gorski J., Free PMC Article | 08/6/2011 |
| NF-kappaB modulates the expression of PDGF-a and PDGF-B in rat retina induced by IL-1beta. | [Modulation of expression of platelet-derived growth factor by nuclear transcription factor-kappaB in rats retina].
Mo B, Liu W, Yang L, Jiao J. | 11/6/2010 |
| LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasing PDGF-Ralpha on pulmonary fibroblasts | Bacterial lipopolysaccharide enhances PDGF signaling and pulmonary fibrosis in rats exposed to carbon nanotubes.
Cesta MF, Ryman-Rasmussen JP, Wallace DG, Masinde T, Hurlburt G, Taylor AJ, Bonner JC., Free PMC Article | 08/16/2010 |
| the PDGF/PDGF receptor system is expressed in pituitary folliculostellate cells and is involved in VEGF regulation. | Platelet-derived growth factor (PDGF) and PDGF receptor expression and function in folliculostellate pituitary cells.
Kowarik M, Onofri C, Colaco T, Stalla GK, Renner U. | 05/31/2010 |
| Report effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes. | Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes.
Kim TH, Moon JH, Savard CE, Kuver R, Lee SP. | 01/21/2010 |
| PDGFR (platelet derived growth factor receptor)-alpha mRNA Is Upregulated in Acutely-Rejecting, and PDGF-A and PDGF-C mRNAis upregulated in Chronically-Rejecting Cardiac Allografts | PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.
Tuuminen R, Nykänen AI, Krebs R, Soronen J, Pajusola K, Keränen MA, Koskinen PK, Alitalo K, Lemström KB. | 01/21/2010 |
| PDGF-A may act to mobilize oligodendrocyte progenitor cells that then respond to distinct directional signals to distribute appropriately within the CNS. | Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway.
Frost EE, Zhou Z, Krasnesky K, Armstrong RC., Free PMC Article | 01/21/2010 |
| PTH-induced bone marrow fibrosis is mediated by PDGF-A via a phosphoinositide 3-kinase-dependent signaling pathway. | Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism.
Lowry MB, Lotinun S, Leontovich AA, Zhang M, Maran A, Shogren KL, Palama BK, Marley K, Iwaniec UT, Turner RT., Free PMC Article | 01/21/2010 |
| the inflammatory response associated with spinal cord injury in cutaneous wound healing resulted in no change in expression of platelet-derived growth factor-A at the wound site in injured rats compared to the control group | The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta1) and platelet-derived growth factor (PDGF)-A at the wound site in rats.
Konya D, Gercek A, Akakin A, Akakin D, Tural S, Cetinel S, Ozgen S, Pamir MN. | 01/21/2010 |
| These results suggest that the neurotrophic effect of platelet-derived growth factor is mediated in part via upregulation of the expression and release of secreted amyloid precursor protein alpha. | Upregulation of amyloid precursor protein by platelet-derived growth factor in hippocampal precursor cells.
Lim JS, Cho H, Hong HS, Kwon H, Mook-Jung I, Kwon YK. | 01/21/2010 |
| insulin and PDGF rely differently on the actin cytoskeleton and on tetanus-toxin-sensitive VAMPs for mobilizing GLUT4 | Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts.
Török D, Patel N, Jebailey L, Thong FS, Randhawa VK, Klip A, Rudich A. | 01/21/2010 |
| analysis of expression of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells | Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC).
Breitkopf K, Roeyen Cv, Sawitza I, Wickert L, Floege J, Gressner AM. | 01/21/2010 |
| platelet-derived growth factor-A and -B are stimulated by sphingosine 1-phosphate through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5 | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5.
Usui S, Sugimoto N, Takuwa N, Sakagami S, Takata S, Kaneko S, Takuwa Y. | 01/21/2010 |
| NHERF2 stimulates PDGF-induced proliferation by increasing PI-3-kinase/Akt, MEKindependent ERK, and Src family kinase-mediated signaling pathways | NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway.
Jung Kang Y, Su Jeon E, Jin Lee H, Oh YS, Suh PG, Sup Jung J, Donowitz M, Ho Kim J. | 01/21/2010 |