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    Mgp matrix Gla protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25333, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    high proliferative glioma cells expressing a high level of MGP may exist and contribute to tumor infiltration and recurrence.

    Functional Role of Matrix gla Protein in Glioma Cell Migration.
    Fu MH, Wang CY, Hsieh YT, Fang KM, Tzeng SF.

    03/2/2019
    Contiuous expression of Matrix Gla protein contributes to crystal formation in kidney of hyperoxaluric animals.

    Matrix Gla protein is involved in crystal formation in kidney of hyperoxaluric rats.
    Lu X, Gao B, Yasui T, Li Y, Liu T, Mao X, Hirose M, Wu Y, Yu D, Zhu Q, Kohri K, Xiao C.

    01/11/2014
    reduced gamma-Carboxylated MGP (cMGP), through an impaired expression of gamma-carboxylase, is involved in the early development of Medial artery calcification (MAC)in diabetes.

    Decreased expression of γ-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein.
    Doyon M, Mathieu P, Moreau P.

    08/3/2013
    Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein

    Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.
    Beazley KE, Eghtesad S, Nurminskaya MV., Free PMC Article

    04/6/2013
    Synthesis of MGP is increased in renal failure and deficiency of GlaMGP is not a primary cause of medial calcification in this condition.

    Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.
    Lomashvili KA, Wang X, Wallin R, O'Neill WC., Free PMC Article

    10/22/2011
    Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.

    Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.
    Mendoza FJ, Martinez-Moreno J, Almaden Y, Rodriguez-Ortiz ME, Lopez I, Estepa JC, Henley C, Rodriguez M, Aguilera-Tejero E.

    06/18/2011
    Matrix Gla protein expression is up-regulated in NRK-52E (rat kidney tubular epithelial) cells exposed to oxalate and calcium oxalate monohydrate crystals.

    Matrix Gla protein expression in NRK-52E cells exposed to oxalate and calcium oxalate monohydrate crystals.
    Gao B, Yasui T, Lu X, Zhou H, Liu J, Liu P, Okada A, Xiao C, Kohri K.

    01/22/2011
    administration of intermedin inhibits vascular calcification development by increasing cMGP levels

    Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.
    Cai Y, Xu MJ, Teng X, Zhou YB, Chen L, Zhu Y, Wang X, Tang CS, Qi YF.

    05/3/2010
    MGP is rapidly upregulated in response to cardiac overload well before the development of LV hypertrophy and post-infarction remodeling process

    Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli.
    Mustonen E, Pohjolainen V, Aro J, Pikkarainen S, Leskinen H, Ruskoaho H, Rysä J.

    02/1/2010
    Immunological rejection is likely to inhibit MGP expression in cryopreserved vascular allografts.

    Relationship between immunological rejection and matrix GLA protein in cryopreserved vascular allografts.
    Kiji T, Dohi Y, Nishizaki K, Sakaguchi H, Nagasaka S, Hayata Y, Yonemasu K, Taniguchi S.

    01/21/2010
    Matrix Gla protein (MGP), a vitamin K-dependent protein known to be synthesized in type II cells, was also found in fetal fibroblasts, where its expression was stimulated by dexamethasone

    Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.
    Gilbert KA, Rannels SR.

    01/21/2010
    MGP has a novel binding activity for vitronectin

    Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development.
    Nishimoto SK, Nishimoto M.

    01/21/2010
    MGP plays a role in lung growth and development, likely via temporally and spatially specific interactions with other branching morphogenesis-related proteins to influence growth processes.

    Matrix GLA protein modulates branching morphogenesis in fetal rat lung.
    Gilbert KA, Rannels SR.

    01/21/2010
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