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    Oxtr oxytocin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25342, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.

    Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.
    El Heni H, Kemenesi-Gedei PB, Pálvölgyi L, Kozma-Szeredi ID, Kis G., Free PMC Article

    01/16/2024
    Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding.

    Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding.
    Demarchi L, Sanson A, Bosch OJ.

    08/9/2023
    Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat.

    Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat.
    Suzuki J, Nagase M, Sato N, Takahashi Y, Okamoto A, Kato F.

    01/21/2023
    Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse.

    Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse.
    Almeida D, Fiori LM, Chen GG, Aouabed Z, Lutz PE, Zhang TY, Mechawar N, Meaney MJ, Turecki G.

    04/16/2022
    Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis.

    Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis.
    D'Addario C, Pucci M, Bellia F, Girella A, Sabatucci A, Fanti F, Vismara M, Benatti B, Ferrara L, Fasciana F, Celebre L, Viganò C, Elli L, Sergi M, Maccarrone M, Buzzelli V, Trezza V, Dell'Osso B., Free PMC Article

    04/9/2022
    Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.

    Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.
    Wang F, Yin XS, Lu J, Cen C, Wang Y.

    04/9/2022
    Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2.

    Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2.
    Khodagholi F, Maleki A, Motamedi F, Mousavi MA, Rafiei S, Moslemi M.

    04/9/2022
    Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors.

    Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors.
    Mardanpour M, Ghavidel N, Asadi S, Khodagholi F.

    03/19/2022
    Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms.

    Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms.
    Hu B, Boyle CA, Lei S., Free PMC Article

    02/19/2022
    Oxytocin receptor expression in the midbrain dorsal raphe is dynamic across female reproduction in rats.

    Oxytocin receptor expression in the midbrain dorsal raphe is dynamic across female reproduction in rats.
    Grieb ZA, Lonstein JS.

    12/11/2021
    Ultrastructural Evidence for Oxytocin and Oxytocin Receptor at the Spinal Dorsal Horn: Mechanism of Nociception Modulation.

    Ultrastructural Evidence for Oxytocin and Oxytocin Receptor at the Spinal Dorsal Horn: Mechanism of Nociception Modulation.
    Martínez-Lorenzana G, Palma-Tirado L, Cifuentes-Diaz C, González-Hernández A, Condés-Lara M.

    10/30/2021
    Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.

    Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
    Salehi MS, Neumann ID, Jurek B, Pandamooz S., Free PMC Article

    09/25/2021
    Sex-dimorphic role of prefrontal oxytocin receptors in social-induced facilitation of extinction in juvenile rats.

    Sex-dimorphic role of prefrontal oxytocin receptors in social-induced facilitation of extinction in juvenile rats.
    Maroun M, Sarussi-Elyahu A, Yaseen A, Hatoum OA, Kritman M., Free PMC Article

    07/3/2021
    Downregulation of microRNA29c reduces pain after child delivery by activating the oxytocinGABA pathway.

    Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway.
    Li C, Wang X, Zhang G, Zhang Y, Xia F, Xu S, Shen X., Free PMC Article

    04/24/2021
    Cellular mechanism underlying oxytocin-stimulated Cl(-) secretion in rat cauda epididymal epithelium.

    Cellular mechanism underlying oxytocin-stimulated Cl(-) secretion in rat cauda epididymal epithelium.
    Gao DD, Wang LL, Xu JW, Qiu ZE, Zhu YX, Zhang YL, Zhou WL.

    12/19/2020
    Expression of OXTR became reduced following SPS in mPFC and amygdala, the latter exhibited higher therapeutic specificity to OXT. Expression of CRHR1 appeared more sensitive than CRHR2 to SPS, higher CRHR1 protein levels were found in mPFC and amygdala.

    Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder.
    Wang SC, Lin CC, Tzeng NS, Tung CS, Liu YP., Free PMC Article

    08/3/2019
    Findings suggest that forebrain oxytocin receptor and vasopressin 1a are down-regulated in response to chronic oxytocin treatment.

    Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain.
    Freeman SM, Ngo J, Singh B, Masnaghetti M, Bales KL, Blevins JE., Free PMC Article

    03/9/2019
    oxytocin receptor binding density was higher in the dorsal lateral septum and nucleus accumbens shell in rats that underwent social instability stress.

    Social instability stress in adolescent male rats reduces social interaction and social recognition performance and increases oxytocin receptor binding.
    Hodges TE, Baumbach JL, Marcolin ML, Bredewold R, Veenema AH, McCormick CM.

    05/5/2018
    Pharmacological blockade of paraventricular nucleus oxytocin receptors prevented the anxiolytic effect of synthetic neuropeptide S.

    Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis.
    Grund T, Goyon S, Li Y, Eliava M, Liu H, Charlet A, Grinevich V, Neumann ID., Free PMC Article

    01/20/2018
    To investigate confounding effects of long-term antipsychotic medication, study treated rats with clozapine or haloperidol for 12weeks and assessed expression of the oxytocin receptor in cortical and subcortical brain regions; found no differences between antipsychotic-treated rats and controls.

    Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study.
    Uhrig S, Hirth N, Broccoli L, von Wilmsdorff M, Bauer M, Sommer C, Zink M, Steiner J, Frodl T, Malchow B, Falkai P, Spanagel R, Hansson AC, Schmitt A.

    01/6/2018
    Oxytocin receptor binding density was higher in juveniles than in adults in regions associated with reward and socio-spatial memory and higher in adults than in juveniles in key regions of the social decision-making network and in cortical regions.

    Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network.
    Smith CJW, Poehlmann ML, Li S, Ratnaseelan AM, Bredewold R, Veenema AH., Free PMC Article

    10/21/2017
    A critical role for endogenous nucleus tractus solitarius OT-R signaling in mediating the intake-inhibitory effects of endogenous gastrointestinal satiation signals and in diet-induced thermogenesis.

    Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation-Mediated Feeding and Thermogenic Control in Male Rats.
    Ong ZY, Bongiorno DM, Hernando MA, Grill HJ., Free PMC Article

    10/7/2017
    Results show that extracellular oxytocin release in the central amygdala is similar between males and females and that OTR in the central amygdala plays a causal role in the regulation of social interest toward juvenile conspecifics in males.

    Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats.
    Dumais KM, Alonso AG, Bredewold R, Veenema AH., Free PMC Article

    07/15/2017
    These findings suggest a sex-specific role of the OTr in the Bed Nucleus Stria Terminalis in the regulation of social recognition.

    Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition.
    Dumais KM, Alonso AG, Immormino MA, Bredewold R, Veenema AH., Free PMC Article

    04/22/2017
    Oxytocin receptor expression was identified in calcitonin gene-related peptide containing trigeminal ganglion neurons.

    Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders.
    Tzabazis A, Mechanic J, Miller J, Klukinov M, Pascual C, Manering N, Carson DS, Jacobs A, Qiao Y, Cuellar J, Frey WH 2nd, Jacobs D, Angst M, Yeomans DC.

    02/25/2017
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