| Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation. | Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation.
Jeon S, Scorletti E, Dempsey J, Buyco D, Lin C, Saiman Y, Bayen S, Harkin J, Martin J, Hooks R, Ogretmen B, Argemi J, Melo L, Bataller R, Carr RM., Free PMC Article | 11/30/2023 |
| CerS6 triggered by high glucose activating the TLR4/IKKbeta pathway regulates ferroptosis of LO2 cells through mitochondrial oxidative stress. | CerS6 triggered by high glucose activating the TLR4/IKKβ pathway regulates ferroptosis of LO2 cells through mitochondrial oxidative stress.
Li D, Tian L, Nan P, Zhang J, Zheng Y, Jia X, Gong Y, Wu Z. | 06/15/2023 |
| CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8. | CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8.
Li X, Jiang X, Lu J, Lin Y, Jiang L, Li Y, Wan F, Wang C. | 11/5/2022 |
| Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. | Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.
Lee WK, Maaß M, Quach A, Poscic N, Prangley H, Pallott EC, Kim JL, Pierce JS, Ogretmen B, Futerman AH, Thévenod F., Free PMC Article | 05/14/2022 |
| Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer. | Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Xing J, Yi J., Free PMC Article | 01/8/2022 |
| AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis. | AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis.
Qi D, Song X, Xue C, Yao W, Shen P, Yu H, Zhang Z. | 01/8/2022 |
| CEBPgamma facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. | CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Shi H, Niimi A, Takeuchi T, Shiogama K, Mizutani Y, Kajino T, Inada K, Hase T, Hatta T, Shibata H, Fukui T, Chen-Yoshikawa TF, Nagano K, Murate T, Kawamoto Y, Tomida S, Takahashi T, Suzuki M., Free PMC Article | 07/10/2021 |
| CERS6 required for cell migration and metastasis in lung cancer. | CERS6 required for cell migration and metastasis in lung cancer.
Suzuki M, Cao K, Kato S, Mizutani N, Tanaka K, Arima C, Tai MC, Nakatani N, Yanagisawa K, Takeuchi T, Shi H, Mizutani Y, Niimi A, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Iwaki S, Fujii S, Satou A, Tamiya-Koizumi K, Murate T, Kyogashima M, Tomida S, Takahashi T., Free PMC Article | 05/8/2021 |
| Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA. | Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA.
Bao G, Huang J, Pan W, Li X, Zhou T., Free PMC Article | 01/23/2021 |
| These associations were successfully replicated in an independent collection of Indigenous Australian T2D cases and controls. These SNPs all lie within the gene encoding ceramide synthase 6 (CERS6) and thus may regulate ceramide synthesis. | Noncoding Variations in the Gene Encoding Ceramide Synthase 6 are Associated with Type 2 Diabetes in a Large Indigenous Australian Pedigree.
Good DA, Duffy DL, Good M, Xia Guo C, Busfield F, Shaw A, Shaw JTE. | 12/21/2019 |
| CERS6 interferes with Fas-Fas-associated protein with death domain death-inducing signaling complex assembly. CERS6 may serve as a biomarker in determining the effectiveness of anticancer agents acting via the extrinsic pathway in T-cell acute lymphoblastic leukemia. | Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia.
Verlekar D, Wei SJ, Cho H, Yang S, Kang MH., Free PMC Article | 11/16/2019 |
| CerS6 could mediate an effective response to cisplatin in chemoresistant oral squamous cell carcinoma. | CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Li S, Wu Y, Ding Y, Yu M, Ai Z. | 10/5/2019 |
| The human CERS6 gene promoter harbors a large CpG island (94 CpGs) and multiple transcription factor binding sites (TFBS), which support precise transcriptional regulation and signaling functions. Additional regulation is conferred by 15 microRNA (miRNA) target sites identified in the CERS6 3'-UTR region | Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution.
Holmes RS, Barron KA, Krupenko NI., Free PMC Article | 06/1/2019 |
| Study found that overexpression of CERS6 in gastric cancer (GC) cells facilitated cell proliferation and spread as well as xenograft proliferation, resulting in a significantly worse prognosis of the patients with GC. These findings suggest that CERS6 overexpression can be a useful biomarker for predicting the outcomes of GC patients. | Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Uen YH, Fang CL, Lin CC, Hseu YC, Hung ST, Sun DP, Lin KY. | 05/18/2019 |
| both SphK1 overexpression and S1P addition increased mTOR phosphorylation as shown by ELISA, while S1PR2 inhibition had the inverse effect. These data suggest that CerS6 and SphK1 regulate mTOR signaling in breast cancer cell proliferation. Moreover, mTOR activity can be regulated by the balance between S1P and C16ceramide, which is generated by CerS6. | C16‑ceramide and sphingosine 1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Kim MH, Park JW, Lee EJ, Kim S, Shin SH, Ahn JH, Jung Y, Park I, Park WJ. | 12/22/2018 |
| ceramide synthase (CerS)6 was specifically up-regulated in zone 3 hepatocytes in alcoholic steatosis | A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
Williams B, Correnti J, Oranu A, Lin A, Scott V, Annoh M, Beck J, Furth E, Mitchell V, Senkal CE, Obeid L, Carr RM., Free PMC Article | 10/13/2018 |
| This study has shown that by direct transcriptional activation of CerS6, p53 can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response. | CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress.
Fekry B, Jeffries KA, Esmaeilniakooshkghazi A, Ogretmen B, Krupenko SA, Krupenko NI., Free PMC Article | 05/6/2017 |
| silencing of CerS6 induced the increased expression of GLUT1, which downregulated the expression of WNT5A and enhanced the invasion and proliferation of melanoma cells. | Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A.
Tang Y, Cao K, Wang Q, Chen J, Liu R, Wang S, Zhou J, Xie H. | 12/31/2016 |
| Identification of CerS6 and ceramide pathways as a novel Methotrexate target. | Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
Fekry B, Esmaeilniakooshkghazi A, Krupenko SA, Krupenko NI., Free PMC Article | 08/20/2016 |
| These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths. | Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.
Sassa T, Hirayama T, Kihara A., Free PMC Article | 08/20/2016 |
| stichoposide D inhibits growth of experimental leukemia by activating Fas/ceramide synthase 6/p38 kinase in lipid rafts | By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts.
Yun SH, Park ES, Shin SW, Ju MH, Han JY, Jeong JS, Kim SH, Stonik VA, Kwak JY, Park JI., Free PMC Article | 08/20/2016 |
| Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients. | Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Eberle M, Ebel P, Mayer CA, Barthelmes J, Tafferner N, Ferreiros N, Ulshöfer T, Henke M, Foerch C, de Bazo AM, Grösch S, Geisslinger G, Willecke K, Schiffmann S. | 04/30/2016 |
| On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction. | Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H., Free PMC Article | 12/5/2015 |
| Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase in a JNK-dependent manner that is independent of CerS6 activity. | Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.
Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C., Free PMC Article | 09/5/2015 |
| CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration. | Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.
Edmond V, Dufour F, Poiroux G, Shoji K, Malleter M, Fouqué A, Tauzin S, Rimokh R, Sergent O, Penna A, Dupuy A, Levade T, Theret N, Micheau O, Ségui B, Legembre P. | 05/2/2015 |