| calpastatin protein and mRNA levels were low at early developmental time points and increased dramatically by postnatal day 30 | Calpain 1 and Calpastatin expression is developmentally regulated in rat brain.
Li Y, Bondada V, Joshi A, Geddes JW., Free PMC Article | 01/21/2010 |
| Over-expression of calpastatin inhibits calpain activation and improves myocardial function in endotoxaemia. | Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.
Li X, Li Y, Shan L, Shen E, Chen R, Peng T. | 01/21/2010 |
| In hippocampal slices, both basic excitability and long-term synaptic efficacy are significantly increased upon treatment with a synthetic membrane-permeable activator calpastatin peptide. | Synthetic calpain activator boosts neuronal excitability without extra Ca2+.
Világi I, Kiss DS, Farkas A, Borbély S, Tárnok K, Halasy K, Bánóczi Z, Hudecz F, Friedrich P. | 01/21/2010 |
| 2.4-A-resolution crystal structure of the calcium-bound calpain 2 heterodimer bound by one of the four inhibitory domains of calpastatin | Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.
Hanna RA, Campbell RL, Davies PL. | 01/21/2010 |
| 3.0 A structure of Ca(2+)-bound m-calpain in complex with the first calpastatin repeat, both from rat, revealing the mechanism of exclusive specificity | Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Moldoveanu T, Gehring K, Green DR., Free PMC Article | 01/21/2010 |
| Role of the calpain-calpastatin system in the density-dependent growth arrest. | Role of the calpain-calpastatin system in the density-dependent growth arrest.
Stifanese R, Averna M, De Tullio R, Salamino F, Cantoni C, Mingari MC, Prato C, Pontremoli S, Melloni E. | 01/21/2010 |
| c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells | Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc-negative cells by calpastatin suppression.
Niapour M, Yu Y, Berger SA. | 01/21/2010 |
| Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia. | Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia.
Sun M, Xu C. | 01/21/2010 |
| It was concluded that the presence of the XL-domain in these isoforms is not relevant for the formation of the calpain/calpastatin complex in the absence of calcium, that is the interaction of calpastatin with inactive calpain. | Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons.
De Tullio R, Averna M, Stifanese R, Parr T, Bardsley RG, Pontremoli S, Melloni E. | 01/21/2010 |
| Although desmin depletion was not statistical significance, a significant inverse relationship was found between the mu-calpain/calpastatin ratio and the amount of desmin in myofibrils during hindlimb unweighting and reweighting in skeletal muscle. | Calpain/calpastatin activities and substrate depletion patterns during hindlimb unweighting and reweighting in skeletal muscle.
Enns DL, Raastad T, Ugelstad I, Belcastro AN. | 01/21/2010 |
| findings support the hypothesis that dysregulation of the calpain-calpastatin system may play a role in the onset of acute pancreatitis | Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat.
Weber H, Jonas L, Hühns S, Schuff-Werner P. | 01/21/2010 |
| calpastatin overexpression in L8 myoblasts does not inhibit cell proliferation and alignment, but prevents myoblast fusion and fusion-associated protein degradation | Overexpression of calpastatin inhibits L8 myoblast fusion.
Barnoy S, Maki M, Kosower NS. | 01/21/2010 |
| CAST overexpression could be used as a therapeutic strategy to prevent progression of liver injury where liver regeneration is severely hampered. | Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity.
Limaye PB, Bhave VS, Palkar PS, Apte UM, Sawant SP, Yu S, Latendresse JR, Reddy JK, Mehendale HM. | 01/21/2010 |
| Increased calpastatin levels found in juvenile rats muted calpain activity and neuronal apoptosis, following spinal cord injury. | Higher calpastatin levels correlate with resistance to calpain-mediated proteolysis and neuronal apoptosis in juvenile rats after spinal cord injury.
Wingrave JM, Sribnick EA, Wilford GG, Matzelle DD, Mou JA, Ray SK, Hogan EL, Banik NL. | 01/21/2010 |
| there is a discordant expression pattern of cardiac calpastatin mRNA and protein in the hypoxic | Role and differential expression of calpastatin mRNA and protein in cultured cardiomyocytes exposed to hypoxic stress.
Lin H, Risbood MP, Jain A, Vacanti V, Lee T. | 01/21/2010 |
| Calpastatin was capable of simultaneously binding four molecules of calpain. | Calpastatin simultaneously binds four calpains with different kinetic constants.
Hanna RA, Garcia-Diaz BE, Davies PL. | 01/21/2010 |
| induction of degradation by caspase-1 in myoblast differentiation and fusion | Caspase-1-induced calpastatin degradation in myoblast differentiation and fusion: cross-talk between the caspase and calpain systems.
Barnoy S, Kosower NS. | 01/21/2010 |
| The results suggest that sepsis-induced muscle wasting is associated with increased calpain activity, secondary to reduced calpastatin activity, and that caspase-3 activity is not involved in the catabolic response to sepsis. | Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3.
Wei W, Fareed MU, Evenson A, Menconi MJ, Yang H, Petkova V, Hasselgren PO. | 01/21/2010 |