| Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B. | Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B.
Zhang X, Nham GTH, Ito K, Shinomura T. | 02/20/2021 |
| Induction of OA caused downregulation of Col2a1. Expression of Col2a1 showed upregulation in therapeutic group with separate administration chondroitin sulfate or a probiotic diet and the cumulative effects in case of co-administration. | The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis.
Korotkyi OH, Vovk AA, Dranitsina AS, Falalyeyeva TM, Dvorshchenko KO, Fagoonee S, Ostapchenko LI. | 08/31/2019 |
| E1 and E2 enhancer activities in type II collagen and aggrecan are regulated through distinct epigenetic modifications by histone deacetylase 10 and sirtuin 6. | Expression of type II collagen and aggrecan genes is regulated through distinct epigenetic modifications of their multiple enhancer elements.
Nham GTH, Zhang X, Asou Y, Shinomura T. | 06/22/2019 |
| These findings suggest a novel mechanism of action of SOX5/6; namely, the SOX9/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1. | A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6.
Yasuda H, Oh CD, Chen D, de Crombrugghe B, Kim JH., Free PMC Article | 06/3/2017 |
| The ERK1/2 and Smad2/3 signaling pathways regulate type II collagen and aggrecan expression in rat chondrocytes. | Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways.
Zhu Y, Tao H, Jin C, Liu Y, Lu X, Hu X, Wang X. | 06/28/2016 |
| Local adipose tissue stem cells protected the bronchial stump after pneumonectomy and induced local changes in Col2a1 gene expression. | Stem cells protect the bronchial stump in rat, increasing Sox6, Col2a1, and Agc1 expression.
Llontop P, Santana-Rodríguez N, Clavo B, Quintana A, Fiuza MD, Camacho R, Santana-Rodríguez A, Santana C, Ruíz-Caballero JA. | 02/28/2015 |
| Rat collagen II citrullination decreased the adhesion of human synovial fibroblasts and rat mesenchymal stem cells by decreasing the binding of integrins alpha10beta1 and alpha11beta1 (but not alpha1beta1 and alpha2beta1)to Arg-containing motifs. It decreased MSC survival. | Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner.
Sipilä K, Haag S, Denessiouk K, Käpylä J, Peters EC, Denesyuk A, Hansen U, Konttinen Y, Johnson MS, Holmdahl R, Heino J. | 10/11/2014 |
| Screening of the Col2a1 gene, and enhancer domain, for the sequence encoded regulation of its expression. | A newly identified enhancer element responsible for type II collagen gene expression.
Shinomura T, Ito K, Höök M, Kimura JH. | 05/18/2013 |
| While urinary C-telopeptide of type II collagen was significantly increased during the experimental periods, serum type II procollagen-C-peptide was significantly decreased at the early phase. | Skeletal unloading induces a full-thickness patellar cartilage defect with increase of urinary collagen II CTx degradation marker in growing rats.
Tomiya M, Fujikawa K, Ichimura S, Kikuchi T, Yoshihara Y, Nemoto K. | 12/13/2011 |
| immunohistochemical findings are consistent with the concept that the major source of serum c-telopeptide type Ii is the damaged articular cartilage in collagen-induced arthritis. | Early elevation in circulating levels of C-telopeptides of type II collagen predicts structural damage in articular cartilage in the rodent model of collagen-induced arthritis.
Oestergaard S, Chouinard L, Doyle N, Smith SY, Tankó LB, Qvist P. | 10/4/2011 |
| Substate stiffness regulates the gene expression of Col1alpha1, Col2alpha1, aggrecan, MMP-3, MMp-13, and ADAMTS-5 in rat annular (intervertebral disc) cells. | Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells.
Zhang YH, Zhao CQ, Jiang LS, Dai LY. | 08/27/2011 |
| important role of Col2a1 gene strong interaction sites on Col2a1 transcription regulation by SOX9 | Identification of SOX9 interaction sites in the genome of chondrocytes.
Oh CD, Maity SN, Lu JF, Zhang J, Liang S, Coustry F, de Crombrugghe B, Yasuda H., Free PMC Article | 06/18/2011 |
| Second harmonic generation intensity as a function of the excitation polarization angle for type I and type II collagens, was measured. | The discrimination of type I and type II collagen and the label-free imaging of engineered cartilage tissue.
Su PJ, Chen WL, Li TH, Chou CK, Chen TH, Ho YY, Huang CH, Chang SJ, Huang YY, Lee HS, Dong CY. | 02/26/2011 |
| study found gene transcripts of type II and X collagen were most abundant at day 10 postnatally in the spheno-occipital synchondrosis | Development dependent collagen gene expression in the rat cranial base growth plate.
Römer P, Weingärtner J, Roldán JC, Proff P, Reicheneder C. | 10/23/2010 |
| mechanical stress from a functional lateral shift of the mandible have effects the expression of type II collagen | Functional lateral shift of the mandible effects on the expression of ECM in rat temporomandibular cartilage.
Wattanachai T, Yonemitsu I, Kaneko S, Soma K. | 01/21/2010 |
| Data reveal that COL2 is attacked at a susceptible peptide bond at the surface of developing articular cartilage canals, and is cleaved by MMP-13. | Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development.
Lee ER, Lamplugh L, Kluczyk B, Leblond CP, Mort JS. | 01/21/2010 |
| During pubertal growth spurt, two-week static compression reduced caudal vertebrae growth rates; this mechanical growth modulation occurred with decreased type II and X collagen proteins in the growth plate. | Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix.
Cancel M, Grimard G, Thuillard-Crisinel D, Moldovan F, Villemure I. | 01/21/2010 |
| Cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. | Ultrastructural co-localization of cochlin and type II collagen in the rat semicircular canal.
Mizuta K, Ikezono T, Iwasaki S, Arai M, Hashimoto Y, Pawankar R, Watanabe T, Shindo S, Mineta H. | 01/21/2010 |
| results suggest that COLII is more immunogenic and arthritogenic in an acidic environment than in a neutral environmen | A pH-induced modification of CII increases its arthritogenic properties.
Lundberg K, Ottosson L, Westman E, Sunnerhagen M, Hultenby K, Harris HE. | 01/21/2010 |
| Dysregulated genes expressed in rats with surgically-induced osteoarthritis included Mmp13, Adamts5, Ptges, Cxcr4, Ccl2, and Col2a1. | Global analyses of gene expression in early experimental osteoarthritis.
Appleton CT, Pitelka V, Henry J, Beier F. | 01/21/2010 |
| The present study shows the reduced Col II expression in hypothyroid rat ovary, with the concomitant increase in Col II degradation. This information will be useful for further studies on reproductive disorders. | Localization and thyroid hormone influenced expression of collagen II in ovarian tissue.
Saha S, Ghosh P, Mitra D, Mukherjee S, Bhattacharya S, Roy SS. | 01/21/2010 |