| Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2. | Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.
Berg RA, Moseley JB., Free PMC Article | 02/24/2023 |
| Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division. | Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
Opalko HE, Miller KE, Kim HS, Vargas-Garcia CA, Singh A, Keogh MC, Moseley JB., Free PMC Article | 09/10/2022 |
| Cdr2 nodal density, which scales with cell size, is used by the cell to sense and control its size. By analyzing cells of different widths, the authors first show that cdr2(+) cells divide at a fixed cell surface area. However, division in the cdr2Delta mutant is more closely specified by cell volume. | Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.
Facchetti G, Knapp B, Flor-Parra I, Chang F, Howard M., Free PMC Article | 02/8/2020 |
| SIN-dependent phosphorylation of Cdr2 promotes its interaction with the 14-3-3 protein Rad24 that sequesters it in the cytoplasm during cell division. | SIN-Dependent Dissociation of the SAD Kinase Cdr2 from the Cell Cortex Resets the Division Plane.
Rincon SA, Estravis M, Dingli F, Loew D, Tran PT, Paoletti A. | 07/14/2018 |
| distinct levels in Pom1 gradients delineate a medial Cdr2 domain, for cell division placement, and control its activity, for mitotic commitment. [Pom1; Cdr2] | Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.
Bhatia P, Hachet O, Hersch M, Rincon SA, Berthelot-Grosjean M, Dalessi S, Basterra L, Bergmann S, Paoletti A, Martin SG. | 03/26/2018 |
| the association of Cdr2 effectors with different domains might constrain Cdr1 and Wee1 spatially to promote Wee1 inhibition upon Cdr2 kinase activation. | Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2.
Guzmán-Vendrell M, Rincon SA, Dingli F, Loew D, Paoletti A. | 06/28/2016 |
| Cdr2 was the only cell cycle target of Pom1 kinase activity that was identified in cells. | Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN, Deng L, Wu Y, Baldissard S, Adamo ME, Gerber SA, Moseley JB., Free PMC Article | 02/6/2016 |
| The dual regulation exerted by Pom1 on Cdr2 prevents Cdr2 assembly into stable nodes in the cell tip region where Pom1 concentration is high. | Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.
Rincon SA, Bhatia P, Bicho C, Guzman-Vendrell M, Fraisier V, Borek WE, Alves Fde L, Dingli F, Loew D, Rappsilber J, Sawin KE, Martin SG, Paoletti A., Free PMC Article | 09/27/2014 |
| Pom1 phosophorylated the C-terminal domain of Cdr2, and this modification reduced Cdr2-T166 phosphorylation by Ssp1 | Dueling kinases regulate cell size at division through the SAD kinase Cdr2.
Deng L, Baldissard S, Kettenbach AN, Gerber SA, Moseley JB., Free PMC Article | 09/13/2014 |
| Data show that the protein Skb1 interacted with both Cdr1 and the Cdr1 inhibitory target Wee1. | Compartmentalized nodes control mitotic entry signaling in fission yeast.
Deng L, Moseley JB., Free PMC Article | 01/18/2014 |
| Cdr2p functions at two positions within the cell at discrete cell cycle stages to influence the timing of mitotic entry and cytokinesis, respectively | The GIN4 family kinase, Cdr2p, acts independently of septins in fission yeast.
Morrell JL, Nichols CB, Gould KL. | 01/21/2010 |