| Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. | Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats.
Rahamim N, Liran M, Aronovici C, Flumin H, Gordon T, Urshansky N, Barak S., Free PMC Article | 08/9/2024 |
| Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia. | Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia.
Martínez-Alonso E, Escobar-Peso A, Guerra-Pérez N, Roca M, Masjuan J, Alcázar A., Free PMC Article | 05/22/2023 |
| Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy. | Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.
Li Y, Tong F, Zhang Y, Cai Y, Ding J, Wang Q, Wang X., Free PMC Article | 10/15/2022 |
| CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy. | CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.
Li Y, Tong F, Liu L, Su Z, Ding J, Wang Q, Wang X. | 04/23/2022 |
| GSK3beta Interacts With CRMP2 and Notch1 and Controls T-Cell Motility. | GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility.
Fazil MHUT, Prasannan P, Wong BHS, Kottaiswamy A, Salim NSBM, Sze SK, Verma NK., Free PMC Article | 03/5/2022 |
| Resilience in the LPS-induced acute depressive-like behaviors: Increase of CRMP2 neuroprotection and microtubule dynamics in hippocampus. | Resilience in the LPS-induced acute depressive-like behaviors: Increase of CRMP2 neuroprotection and microtubule dynamics in hippocampus.
Wu Z, Wang G, Xiao L, Wei Y, Wang H, Zhou L, Sun L. | 10/2/2021 |
| Bone marrow-derived mesenchymal stem cells improve post-ischemia neurological function in rats via the PI3K/AKT/GSK-3beta/CRMP-2 pathway. | Bone marrow-derived mesenchymal stem cells improve post-ischemia neurological function in rats via the PI3K/AKT/GSK-3β/CRMP-2 pathway.
Lin X, Chen H, Chen M, Li T, Lai Y, Lin L, Lin P, Liu J, Zhang Y, Chen R, Du H, Jiang X, Liu N. | 07/31/2021 |
| Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury. | Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury.
Moutal A, Ji Y, Bellampalli SS, Khanna R., Free PMC Article | 06/5/2021 |
| aFGF Promotes Neurite Growth by Regulating GSK3beta-CRMP2 Signaling Pathway in Cortical Neurons Damaged by Amyloid-beta. | aFGF Promotes Neurite Growth by Regulating GSK3β-CRMP2 Signaling Pathway in Cortical Neurons Damaged by Amyloid-β.
Cao Q, Meng T, Man J, Peng D, Chen H, Xiang Q, Su Z, Zhang Q, Huang Y. | 11/21/2020 |
| Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking. | Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
Buchta WC, Moutal A, Hines B, Garcia-Keller C, Smith ACW, Kalivas P, Khanna R, Riegel AC., Free PMC Article | 10/10/2020 |
| elevated ammonia level may induce neuronal dysfunction via abnormal calcium influx and calpain-dependent CRMP-2 cleavage | Ammonia induces calpain-dependent cleavage of CRMP-2 during neurite degeneration in primary cultured neurons.
Cai Z, Zhu X, Zhang G, Wu F, Lin H, Tan M., Free PMC Article | 07/25/2020 |
| Dorsal root ganglion neurons expressing the CRMP2-K374A mutant also exhibited total sodium current increases after exposure to TNF-alpha, indicating that these effects were independent of SUMOylation of CRMP2. | TNF-α mediated upregulation of Na(V)1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation.
de Macedo FHP, Aires RD, Fonseca EG, Ferreira RCM, Machado DPD, Chen L, Zhang FX, Souza IA, Lemos VS, Romero TRL, Moutal A, Khanna R, Zamponi GW, Cruz JS., Free PMC Article | 07/11/2020 |
| The increase of CDK5 activity can lead to CRMP-2 hyperphosphorylation, which results in the difficult repair of damaged optic nerve. Therefore, inhibition on CDK5 could promote the repair of damaged optic nerve. | Induction of CRMP-2 phosphorylation by CDK5 restricts the repair of damaged optic nerve.
Chen X, Yuan R, Gao L, Huang C, Fan W, Ye J, Chen C. | 05/9/2020 |
| CRMP2 regulated the low voltage-gated (T-type/CaV3.x) channels in sensory neurons. | Activity of T-type calcium channels is independent of CRMP2 in sensory neurons.
Cai S, Shan Z, Zhang Z, Moutal A, Khanna R., Free PMC Article | 04/11/2020 |
| The concordance in normalization of ion channel dysregulation by a CRMP2-directed strategy and of hyperalgesia supports the translational targeting of CRMP2 to curb NF1-related pain. | CRMP2 is necessary for Neurofibromatosis type 1 related pain.
Moutal A, Cai S, Luo S, Voisin R, Khanna R., Free PMC Article | 08/24/2019 |
| The data of this study support a model in which phosphorylation and SUMOylation modification of CRMP2 independently promote the formation and maturation of dendritic spines and participate in the process of dendritic spine plasticity. | Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines.
Zhang J, Zhao B, Zhu X, Li J, Wu F, Li S, Gong X, Cha C, Guo G. | 03/16/2019 |
| The results of the present study suggested that TLR4 may promote the phosphorylation of CRMP2 via the activation of ROCKII in MCAO rats, which further characterizes the pathological mechanism of TLR4 in stroke, and that modulation of TLR4 could be a potential target to limit secondary poststroke brain damage. | Toll‑Like receptor 4 promotes the phosphorylation of CRMP2 via the activation of Rho‑kinase in MCAO rats.
Li XB, Ding MX, Ding CL, Li LL, Feng J, Yu XJ., Free PMC Article | 10/20/2018 |
| The cytosolic regulatory protein collapsin response mediator protein 2 (CRMP2) regulates activity of voltage-gated calcium (specifically N-type or CaV2.2) and voltage-gated sodium channels | CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R., Free PMC Article | 08/4/2018 |
| -overexpression effectively protected the proximal axon from fragmentation within 6 hours after crush. Finally, a proteomic analysis of the optic nerve was performed at 6 hours after crush, which identified further proteins regulated during acute axonal degeneration, including several interactors of CRMP2 | Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration.
Zhang JN, Michel U, Lenz C, Friedel CC, Köster S, d'Hedouville Z, Tönges L, Urlaub H, Bähr M, Lingor P, Koch JC., Free PMC Article | 05/19/2018 |
| CRMP2 expression was significantly upregulated, particularly in the ruptured site of Achilles tendon tissues derived from animals in the mobilization group compared with the immobilization group (0.32+/-0.00 vs. 0.08+/-0.00; P<0.05). Active mobilization may promote Achilles tendon healing via upregulation of CRMP2 protein expression. | Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats.
Qianman B, Jialihasi A, Asilehan B, Kubai A, Aibek R, Wupuer A, Tangkejie W, Maimaitiaili A, Shawutali N, Badelhan A, Aizezi A, Aisaiding A, Wuerliebieke J, Bakyt Y, Makemutibieke E, Jielile J. | 05/5/2018 |
| cross-talk between distinct CRMP2 posttranslational modifications is a key factor in determining NaV1.7 trafficking and localization | Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Dustrude ET, Moutal A, Yang X, Wang Y, Khanna M, Khanna R., Free PMC Article | 04/14/2018 |
| Results indicate that activation of the CDK5/CRMP2 pathway may mediate sevoflurane-induced dendritic development abnormalities in the cortical neurons. The physiological significance of these findings remains to be determined. | Cyclin-dependent kinase 5/Collapsin response mediator protein 2 pathway may mediate sevoflurane-induced dendritic development abnormalities in rat cortical neurons.
Liu Y, Lin D, Liu C, Zhao Y, Shen Z, Zhang K, Cao M, Li Y. | 03/31/2018 |
| The results of this study suggested that the neuroplasticity effect of BMSCs on cerebral ischemia may be associated with the phosphorylated modulation of CRMP2. | Bone marrow stromal cells promote neuroplasticity of cerebral ischemic rats via a phosphorylated CRMP2-mediated mechanism.
He X, Jiang L, Dan QQ, Lv Q, Hu Y, Liu J, Wang SF, Wang TH. | 12/30/2017 |
| Data suggest collapsin response mediator proteins (CRMP) CRMP2 and CRMP4 form complexes to bridge microtubules and actin and work cooperatively to regulate growth cone development and axonal elongation. | CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation.
Tan M, Cha C, Ye Y, Zhang J, Li S, Wu F, Gong S, Guo G., Free PMC Article | 03/12/2016 |
| The present findings demonstrated that the downregulation of genes such as Dpysl2 and Dypsl3 in a rat model of prenatal stress may affect subsequent behavioral changes | Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans.
Lee H, Joo J, Nah SS, Kim JW, Kim HK, Kwon JT, Lee HY, Kim YO, Kim HJ., Free PMC Article | 01/30/2016 |