| Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study. | Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study.
Cibulka M, Brodnanova M, Grendar M, Necpal J, Benetin J, Han V, Kurca E, Nosal V, Skorvanek M, Vesely B, Stanclova A, Lasabova Z, Pös Z, Szemes T, Stuchlik S, Grofik M, Kolisek M., Free PMC Article | 03/19/2022 |
| Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. | Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
Tsao YT, Shih YY, Liu YA, Liu YS, Lee OK., Free PMC Article | 11/11/2017 |
| The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of Parkinson's Disease was replicated in our population. | Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.
Madadi F, Khaniani MS, Shandiz EE, Ayromlou H, Najmi S, Emamalizadeh B, Taghavi S, Jamshidi J, Tafakhori A, Shahidi GA, Darvish H., Free PMC Article | 03/11/2017 |
| Authors performed direct DNA sequencing of the SLC41A1 gene in 100 early-onset PD cases. | Genetic analysis of SLC41A1 in Chinese Parkinson's disease patients.
Wang L, Cheng L, Li NN, Yu WJ, Sun XY, Peng R. | 09/10/2016 |
| Na+-dependent Mg2+ efflux conducted by Na+/Mg2+ exchanger SLC41A1 is regulated by insulin. | Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells.
Mastrototaro L, Tietjen U, Sponder G, Vormann J, Aschenbach JR, Kolisek M. | 02/13/2016 |
| This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese Parkinson disease. | Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function.
Lin CH, Wu YR, Chen WL, Wang HC, Lee CM, Lee-Chen GJ, Chen CM. | 01/17/2015 |
| SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas | SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.
Kolisek M, Galaviz-Hernández C, Vázquez-Alaniz F, Sponder G, Javaid S, Kurth K, Nestler A, Rodríguez-Moran M, Verlohren S, Guerrero-Romero F, Aschenbach JR, Vormann J. | 07/19/2014 |
| Binding partners of SLC41A1, were identified. | Nature of SLC41A1 complexes: report on the split-ubiquitin yeast two hybrid assay.
Nestler A, Sponder G, Rutschmann K, Mastrototaro L, Weise C, Vormann J, Schweigel-Röntgen M, Kolisek M. | 06/14/2014 |
| Alanine350Valine substitution in Na/Mg(2) exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation. | Substitution p.A350V in Na⁺/Mg²⁺ exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation.
Kolisek M, Sponder G, Mastrototaro L, Smorodchenko A, Launay P, Vormann J, Schweigel-Röntgen M., Free PMC Article | 04/12/2014 |
| In normal human kidney tissue, endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary, consistent with the region of cystogenesis observed in nephronophthisis. | Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype.
Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, Yamada H, Halbritter J, Seki G, Konishi M, Zhou W, Yamane T, Murakami S, Caridi G, Ghiggeri G, Abe T, Hildebrandt F., Free PMC Article | 08/10/2013 |
| Direct DNA sequencing of the SLC41A1 and RAB7L1 genes within the PARK16 locus in 205 Chinese Parkinson's disease patients shows no significant difference with controls. | Genetic variants in the RAB7L1 and SLC41A1 genes of the PARK16 locus in Chinese Parkinson's disease patients.
Yan Y, Tian J, Mo X, Zhao G, Yin X, Pu J, Zhang B. | 08/11/2012 |
| The human SLC41A1 gene encodes for the Na+/Mg(2)+ exchanger, the predominant Mg(2)+ efflux system. | Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger.
Kolisek M, Nestler A, Vormann J, Schweigel-Röntgen M. | 02/11/2012 |
| Results indicate that SLC41A1 proteins are a central component of Mg(2+) transport systems, and that their Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain. | SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain.
Mandt T, Song Y, Scharenberg AM, Sahni J. | 11/19/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variability at the PARK16 locus.
Tucci A, Nalls MA, Houlden H, Revesz T, Singleton AB, Wood NW, Hardy J, Paisán-Ruiz C., Free PMC Article | 09/15/2010 |
| SLC41A1 is a novel mammalian Mg2+ carrier | SLC41A1 is a novel mammalian Mg2+ carrier.
Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, Froschauer EM, Martens H, Fleig A, Schweigel M., Free PMC Article | 01/21/2010 |
| The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. | Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.
Goytain A, Quamme GA. | 01/21/2010 |
| Data report the identification and structural characterization of solute carrier family 41 member 1 (SLC41A1), a eukaryotic protein with homology to the bacterial MgtE family of potential Mg(2+) transporters. | The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.
Wabakken T, Rian E, Kveine M, Aasheim HC. | 01/21/2010 |