| The beta2 subunit E155 residue as a proton sensor at the binding site on GABA type A receptors. | The β(2) subunit E155 residue as a proton sensor at the binding site on GABA type A receptors.
Michałowski MA, Czyżewska MM, Iżykowska I, Mozrzymas JW. | 12/18/2021 |
| Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate alpha1beta2gamma2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone. | Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABA(A) Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone.
Germann AL, Pierce SR, Tateiwa H, Sugasawa Y, Reichert DE, Evers AS, Steinbach JH, Akk G., Free PMC Article | 09/25/2021 |
| In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ... | The GABA(A) Receptor β Subunit Is Required for Inhibitory Transmission.
Nguyen QA, Nicoll RA., Free PMC Article | 08/3/2019 |
| the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions. | Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.
Wongsamitkul N, Baur R, Sigel E., Free PMC Article | 05/13/2017 |
| The data of this study reveal that GABAA receptor beta2 and beta3 decrease following 1 h of acute restraint stress and may play a critical role in stress-induced hyperalgesia. | Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
Ma X, Bao W, Wang X, Wang Z, Liu Q, Yao Z, Zhang D, Jiang H, Cui S. | 06/20/2015 |
| These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops. | Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.
Kowalczyk S, Winkelmann A, Smolinsky B, Förstera B, Neundorf I, Schwarz G, Meier JC. | 11/16/2013 |
| The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the alpha(1)beta(2)gamma(2)L receptor. | Interactions of midazolam and propofol on α1β2γ2L and α1β2γ2S gamma aminobutyric acid type A receptors expressed in human embryonic kidney cells.
Hong DM, Kim CS, Eom W, Choi K, Oh YJ, Jung SJ, Kim HS. | 07/14/2012 |
| Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors. | Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.
Wang Q, Pless SA, Lynch JW., Free PMC Article | 01/15/2011 |
| Results indicate that beta2 Loop 9 is involved in receptor activation by GABA, propofol, and pregnanolone and that beta2(Q185) participates in hydrophilic interactions that are important for stabilizing the closed state of the GABA(A) receptor. | A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.
Williams CA, Bell SV, Jenkins A., Free PMC Article | 05/3/2010 |
| the density of surface clusters of GABA(A)R beta2/3 subunits was reduced by D(4), suggesting that the D(4) reduction of GABA(A)R current is associated with a decrease in functional GABA(A)Rs at the plasma membrane. | Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Graziane NM, Yuen EY, Yan Z., Free PMC Article | 01/21/2010 |
| Intriguingly, although there is no direct interaction between GISP and the GABA(B2) subunit, their co-expression in HEK293 cells increases levels of GABA(B2). | GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
Kantamneni S, Holman D, Wilkinson KA, Corrêa SA, Feligioni M, Ogden S, Fraser W, Nishimune A, Henley JM., Free PMC Article | 01/21/2010 |
| Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. | Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.
Mercado J, Czajkowski C., Free PMC Article | 01/21/2010 |
| Using wild type/mutated receptor subunits to identify compounds with anesthetic effect. | The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors.
Yang L, Sonner JM. | 01/21/2010 |
| To elucidate the role of the beta2Ile154-Asp163 region in GABA(A)R activation, each residue was individually mutated to cysteine and coexpressed with wild-type alpha1 subunits in Xenopus laevis oocytes. | Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation.
Newell JG, McDevitt RA, Czajkowski C., Free PMC Article | 01/21/2010 |
| A gate exists between the picrotoxin binding site and the channel's extracellular end, consistent with a closed channel gate in the middle of the channel. | The location of a closed channel gate in the GABAA receptor channel.
Bali M, Akabas MH., Free PMC Article | 01/21/2010 |
| alpha6-beta2-delta GABA A receptors exist in high/low affinity states and expression of subunits alters equilibrium between the two states. | Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.
Hadley SH, Amin J., Free PMC Article | 01/21/2010 |
| analysis of the role of a single M1 residue in the beta2 subunit of GABAA receptor alters channel gating of GABAA receptor in anesthetic modulation and direct activation | A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.
Chang CS, Olcese R, Olsen RW. | 01/21/2010 |
| Activity-dependent bidirectional regulation of receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. | Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons.
Cai X, Flores-Hernandez J, Feng J, Yan Z., Free PMC Article | 01/21/2010 |
| GABA(B2) subunit mRNAs were were first weakly detected on GD 13.5. On GD 15.5, 17.5, and 19.5, these subunit mRNAs were found in the retina, hippocampus, cerebral cortex, spinal cord, and cerebellum area. | Prenatal alteration and distribution of the GABA(B1) and GABA(B2) receptor subunit mRNAs during rat central nervous system development.
Li S, Park MS, Kim MO. | 01/21/2010 |
| Slow GABA-A receptor kinetics are not governed by simple ligand-receptor interactions. Access to the steroid direct gating (and perhaps potentiation) site occurs via the plasma membrane & the membrane concentration of steroid governs direct gating. | Slow actions of neuroactive steroids at GABAA receptors.
Shu HJ, Eisenman LN, Jinadasa D, Covey DF, Zorumski CF, Mennerick S., Free PMC Article | 01/21/2010 |
| The magnitude of GABA(A) receptor beta 2 subunit mRNA expression in rat telencephalic neuronal populations is found to be inferior to that of the distantly related hedgehog. | Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon.
Facciolo RM, Alo' R, Canonaco M, Franzoni MF. | 01/21/2010 |
| identified a number of highly conserved charged residues in the GABAA-R beta2 subunit that appear to be involved in receptor activation | Charged residues in the beta2 subunit involved in GABAA receptor activation.
Kash TL, Dizon MJ, Trudell JR, Harrison NL. | 01/21/2010 |
| Tonic activation of GABA-A receptors in developing hippocampus enhances glutamergic cell excitability and synaptic activity. | In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells.
Marchionni I, Omrani A, Cherubini E., Free PMC Article | 01/21/2010 |
| TM1 glycine on the beta2 subunit is involved with desensitization of GABA-,pentobarbital-, and propofol-induced currents | Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating.
Engblom AC, Carlson BX, Olsen RW, Schousboe A, Kristiansen U. | 01/21/2010 |