| Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model. | Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model.
Zheng C, Gulappa T, Menon B, Menon KMJ., Free PMC Article | 06/26/2021 |
| The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats. | The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
Ameli M, Moghimian M, Saeb F, Bashtani E, Shokoohi M, Salimnejad R, Abtahi H. | 05/2/2020 |
| MiR-122 plays a regulatory role in LHCGR expression. | Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary.
Menon B, Gulappa T, Menon KM., Free PMC Article | 11/4/2017 |
| The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP. | LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.
Gulappa T, Menon B, Menon KMJ., Free PMC Article | 09/23/2017 |
| these results suggest that hCG-induced LHR mRNA downregulation is mediated by cAMP-PKA-ERK1/2 signaling leading to activation of eIF5A hypusination. | Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.
Gulappa T, Menon B, Menon KM., Free PMC Article | 04/9/2016 |
| Demonstrate the presence of LH receptors. Activation resulted in a dose-dependent increase in glucose-induced release of insulin. | The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells.
Parkash J, Lei Z, Rao CV. | 03/26/2016 |
| interaction of NF-kappaB p65 with histone deacetylase in the promoter region of Lhcgr might be responsible for TNF-alpha action on the regulation of LH receptor | TNF-α Suppressed FSH-Induced LH Receptor Expression Through Transcriptional Regulation in Rat Granulosa Cells.
Nakao K, Kishi H, Imai F, Suwa H, Hirakawa T, Minegishi T. | 11/21/2015 |
| miR-122 plays a regulatory role in LH/hCG-induced LHR mRNA down-regulation by increasing LRBP expression through the activation of the SREBP pathway. | miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries.
Menon B, Gulappa T, Menon KM., Free PMC Article | 11/21/2015 |
| Palmitoylated peptide 562-572 of luteinizing hormone receptor increases testosterone level in male rats. | Palmitoylated peptide 562-572 of luteinizing hormone receptor increases testosterone level in male rats.
Derkach KV, Shpakova EA, Shpakov AO. | 08/29/2015 |
| miR-136-3p participated in the down-regulation of LHR mRNA by binding directly to LHR mRNA. | Role of microRNA-136-3p on the expression of luteinizing hormone-human chorionic gonadotropin receptor mRNA in rat ovaries.
Kitahara Y, Nakamura K, Kogure K, Minegishi T. | 07/26/2014 |
| IL-6 up-regulates FSH-induced LHR production by increasing mRNA transcription, and JAK/signal transducer and activator of transcription 3 signaling is required for up-regulation by IL-6 in granulosa cells | IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation.
Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T. | 05/24/2014 |
| protein kinase A, upon activation in response to FSH signaling to raise intracellular cAMP levels in granulosa cells, phosphorylatesbeta-catenin on 2 C-terminal Serine residues to function as a co-activator for both SF1 and TCF3 on the Lhcgr promoter. | Lhcgr expression in granulosa cells: roles for PKA-phosphorylated β-catenin, TCF3, and FOXO1.
Law NC, Weck J, Kyriss B, Nilson JH, Hunzicker-Dunn M., Free PMC Article | 04/7/2014 |
| increased LH concentration induces production of incomplete LHR transcripts in hippocampal cells and decreases immature LHR at the protein level | Regulation of luteinizing hormone receptor in hippocampal neurons following different long-lasting treatments of castrated adult rats.
Abtahi H, Shabani M, Jameie SB, Zarnani AH, Talebi S, Lakpour N, Heidari-Vala H, Edalatkhah H, Akhondi MA, Amiri M, Mahmoudi AR, Sadeghi MR. | 06/22/2013 |
| These data suggest that the association of LRBP with Luteinizing hormone receptor mRNA results in the translocation of the messenger ribonucleoprotein complex to the p bodies leading to decapping and degradation. | Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies.
Menon B, Sinden J, Menon KM., Free PMC Article | 06/22/2013 |
| These results reveal a novel mechanism of luteinizing hormone receptor regulation by GRP78 in the early stage of corpus luteum formation. | Glucose-regulated protein, 78-kilodalton is a modulator of luteinizing hormone receptor expression in luteinizing granulosa cells in rats.
Kogure K, Nakamura K, Ikeda S, Kitahara Y, Nishimura T, Iwamune M, Minegishi T. | 06/8/2013 |
| that LH acts on the uterus to inhibit contraction at ovulation. | Downregulation of LH receptor mRNA in the rat uterus.
Kasahara Y, Kitahara Y, Nakamura K, Minegishi T. | 07/7/2012 |
| Luteinizing hormone upregulates CYP1B1 protein expression in rat R2C leydig cells. | Regulation of cytochrome P450 1B1 expression by luteinizing hormone in mouse MA-10 and rat R2C Leydig cells: role of protein kinase A.
Deb S, Bandiera SM. | 11/26/2011 |
| Neuropeptide Y activity in the medial preoptic area which affects luteinizing hormone surge may be controlled by locus coerulus neurons. | Neuropeptide Y in the medial basal hypothalamus and medial preoptic area during the induction of LH surge may be controlled by locus coeruleus.
Rocha AA, Guerra-Sá R, Silveira NA, Anselmo-Franci JA, Franci CR. | 07/28/2011 |
| VEGF-A-induced vascularization of the ovary is dictated by the expression of LHR and this might play a regulatory role in ovarian physiology. | Expression of vascular endothelial growth factor A during ligand-induced down-regulation of luteinizing hormone receptor in the ovary.
Harada M, Peegel H, Menon KM., Free PMC Article | 01/22/2011 |
| LHR signaling via PKA activates a cofilin-regulated rearrangement of the actin cytoskeleton and active cofilin is required to initiate progesterone secretion by preovulatory granulosa cells. | Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin.
Karlsson AB, Maizels ET, Flynn MP, Jones JC, Shelden EA, Bamburg JR, Hunzicker-Dunn M., Free PMC Article | 01/1/2011 |
| during ligand-induced downregulation, LRBP translocates to ribosomes and associates with LHR mRNA to form an untranslatable ribonucleoprotein complex and inhibits LHR mRNA translation, paving the way to its degradation. | Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation.
Menon B, Peegel H, Menon KM., Free PMC Article | 01/21/2010 |
| LHCGR mRNA is expressed as a function of the passage of granulosa cells across the G1-S phase boundary | Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells.
Cannon JD, Seekallu SV, Vandevoort CA, Chaffin CL., Free PMC Article | 01/21/2010 |
| The LHR-stimulated ERK1/2 pathway stimulates epiregulin release. | The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells.
Andric N, Ascoli M., Free PMC Article | 01/21/2010 |
| These results suggest that the extracellular domain of the LHR is one of the determinants that confer its ability for proper maturation and cell surface expression. | The extracellular domain of luteinizing hormone receptor dictates its efficiency of maturation.
Lin CC, Clouser C, Peegel H, Menon B, Menon KM., Free PMC Article | 01/21/2010 |
| phosphorylation status of the AKAP MAP2D is acutely regulated by LH receptor-mediated modulation of kinase and phosphatase activities via PKA | Luteinizing hormone receptor activation in ovarian granulosa cells promotes protein kinase A-dependent dephosphorylation of microtubule-associated protein 2D.
Flynn MP, Maizels ET, Karlsson AB, McAvoy T, Ahn JH, Nairn AC, Hunzicker-Dunn M., Free PMC Article | 01/21/2010 |