| Novel variants in GABAA receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy. | Novel variants in GABA(A) receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy.
Chakraborty A, Dey S, Kumar K, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J. | 01/28/2023 |
| Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification. | Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification.
Preuss UW, Koller G, Zill P., Free PMC Article | 12/3/2022 |
| Gabra2 is a genetic modifier of Dravet syndrome in mice. | Gabra2 is a genetic modifier of Dravet syndrome in mice.
Hawkins NA, Nomura T, Duarte S, Barse L, Williams RW, Homanics GE, Mulligan MK, Contractor A, Kearney JA., Free PMC Article | 02/12/2022 |
| Longitudinal Links between Adolescent and Peer Conduct Problems and Moderation by a Sensitivity Genetic Index. | Longitudinal Links between Adolescent and Peer Conduct Problems and Moderation by a Sensitivity Genetic Index.
Schlomer GL, Cleveland HH, Feinberg ME, Murray JL, Vandenbergh DJ. | 12/4/2021 |
| Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia. | Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia.
Frajman A, Maggio N, Muler I, Haroutunian V, Katsel P, Yitzhaky A, Weiser M, Hertzberg L. | 07/3/2021 |
| Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse. | Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse.
Yu W, Hill SF, Xenakis JG, Pardo-Manuel de Villena F, Wagnon JL, Meisler MH., Free PMC Article | 03/6/2021 |
| FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome. | FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome.
Jiang L, Li Y, Yang K, Wang Y, Wang J, Cui X, Mao J, Gao Y, Yi P, Wang L, Liu JY., Free PMC Article | 10/3/2020 |
| The strongest association for alcohol use disorder (rs3756007) was located in GABRA2, the strongest association for antisocial behavior (rs11941860) was located in GABRG1, and the interaction term yielded top associations in GABRA2 (rs2119183) and the intergenic region between GABRA2 and GABRG1 (rs536599). | Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.
Deak JD, Gizer IR, Otto JM, Bizon C, Wilhelmsen KC., Free PMC Article | 06/20/2020 |
| The GABRA2 p.T292K variant reduced channel expression and produced mutant channels that were tonically open, even in the absence of GABA. | De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.
Butler KM, Moody OA, Schuler E, Coryell J, Alexander JJ, Jenkins A, Escayg A., Free PMC Article | 07/20/2019 |
| To test an age-varying interaction between a single nucleotide polymorphism in the GABRA2 gene (rs279845) and a preventive intervention in predicting alcohol misuse in a longitudinal study of adolescents (ages 11-20). Intervention effects on adolescent alcohol misuse may differ by genotype, and evidence suggests that the interaction between GABRA2 and intervention effects on alcohol use may vary with age. | PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.
Russell MA, Schlomer GL, Cleveland HH, Feinberg ME, Greenberg MT, Spoth RL, Redmond C, Vandenbergh DJ., Free PMC Article | 04/13/2019 |
| GABRA2 rs279858-linked variants might be a key genetic modulator for heroin vulnerability by affecting the connections of reward network and cognition. The role of the reward network connections that mediates the effects of GABRA2 rs279858 on cognition would be disrupted by heroin addiction. | GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers.
Sun Y, Zhang Y, Zhang D, Chang S, Jing R, Yue W, Lu L, Chen D, Sun Y, Fan Y, Shi J., Free PMC Article | 03/9/2019 |
| Findings suggest GABRA2 variation influences drug-seeking behavior through both alcohol-related and alcohol-independent pathways. | GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use.
Mallard TT, Ashenhurst JR, Harden KP, Fromme K., Free PMC Article | 12/22/2018 |
| rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, allele frequencies were significantly different between patients and controls.Four haplotypes were significantly associated with Bipolar Disorder TA and AG for rs3815762 and rs4868029 in GABRP, GG for rs11636988 and rs8024256 in GABRB3 and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in GABRA6. | Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.
Ren H, Guan L, Zhao L, Lin Y, Wang Y, Yang Z, Li X, Ma X, Cheng X, Deng W, Aitchison KJ, Cao L, Li T. | 08/11/2018 |
| The results of the present study suggest that the GABRA2 genotype interacts with stress in young people with impact on the development of alcohol use and aggressive behaviour. | Stressful life events increase aggression and alcohol use in young carriers of the GABRA2 rs279826/rs279858 A-allele.
Kiive E, Laas K, Vaht M, Veidebaum T, Harro J. | 04/21/2018 |
| GxE interaction: GABRA2 x Positive Peer Involvement on adolescent behavior. | Beyond risk: Prospective effects of GABA Receptor Subunit Alpha-2 (GABRA2) × Positive Peer Involvement on adolescent behavior.
Trucco EM, Villafuerte S, Burmeister M, Zucker RA., Free PMC Article | 03/17/2018 |
| Association between GABRA2 and Alcohol Dependence was essentially limited to individuals with co-occurring Drug Dependence. The GABAA receptor is a heteropentamer so there are multiple potential variants in either GABRA2 or other receptor subunits which might associate with the phenotypes of interest and there is also a high degree of linkage disequilibrium across the region. | The genetics of alcohol dependence and alcohol-related liver disease.
Stickel F, Moreno C, Hampe J, Morgan MY. | 02/24/2018 |
| GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin secretion. | The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.
Te Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL. | 01/20/2018 |
| An uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. | A GABBR2 gene variant modifies pathophysiology in Huntington's disease.
Philpott AL, Fitzgerald PB, Bailey NW, Churchyard A, Georgiou-Karistianis N, Cummins TD. | 07/29/2017 |
| Our study findings showed COMT polymorphism conferring risk and GABRA1 and GABRA2 polymorphism as a protective genotype for Indian male with alcohol dependence (AD) | Candidate genes for alcohol dependence: A genetic association study from India.
Malhotra S, Basu D, Khullar M, Ghosh A, Chugh N., Free PMC Article | 07/22/2017 |
| SNP rs279858 mediates alcohol drinking in alcohol dependent individuals | Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals.
Boyd SJ, Schacht JP, Prisciandaro JJ, Voronin K, Anton RF., Free PMC Article | 01/28/2017 |
| The alpha2 gradually increased during development, showing some layer specificity in the cerebellar cortex. | The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development.
Stojanovic T, Capo I, Aronica E, Adle-Biassette H, Höger H, Sieghart W, Kovacs GG, Milenkovic I. | 01/14/2017 |
| parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p </= .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele | Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.
Salvatore JE, Meyers JL, Yan J, Aliev F, Lansford JE, Pettit GS, Bates JE, Dodge KA, Rose RJ, Pulkkinen L, Kaprio J, Dick DM., Free PMC Article | 12/17/2016 |
| A GABRA2 x Parental Monitoring effect on externalizing behavior trajectory was observed, such that A-carriers were largely unaffected by parental monitoring, whereas trajectory for those with the GG genotype was affected by parental monitoring. | Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele.
Trucco EM, Villafuerte S, Heitzeg MM, Burmeister M, Zucker RA., Free PMC Article | 09/3/2016 |
| GABRA2 SNPs directly predicted adolescent alcohol problems. | Mechanisms in the relation between GABRA2 and adolescent externalizing problems.
Wang FL, Chassin L, Geiser C, Lemery-Chalfant K., Free PMC Article | 08/20/2016 |
| Alcohol dependence-associated variation in GABRA2 is associated with differential expression of the entire cluster of GABAA subunit genes on chromosome 4p12 in neural stem cells. | GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
Lieberman R, Kranzler HR, Joshi P, Shin DG, Covault J., Free PMC Article | 06/28/2016 |