| Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain. | Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain.
Wang J, Zielewicz L, Dong Y, Grewer C., Free PMC Article | 07/16/2022 |
| NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model. | NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model.
Magi S, Piccirillo S, Maiolino M, Lariccia V, Amoroso S. | 08/7/2021 |
| miR-101b targets the neuronal glutamate transporter SLC1A1. Both mRNA and protein levels of SLC1A1 were found to be upregulated in the prefrontal cortex of rats genetically predisposed to develop major depressive disorder. | MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.
Wei YB, Melas PA, Villaescusa JC, Liu JJ, Xu N, Christiansen SH, Elbrønd-Bek H, Woldbye DP, Wegener G, Mathé AA, Lavebratt C., Free PMC Article | 01/13/2018 |
| Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 through binding the YxNxxF (where x stands for any amino acid) motif. | Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif.
Su JF, Wei J, Li PS, Miao HH, Ma YC, Qu YX, Xu J, Qin J, Li BL, Song BL, Xu ZP, Luo J. | 08/5/2017 |
| Exercise-Mediated Increase in Nigral EAAC1 in aging rats. | Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats.
Arnold JC, Salvatore MF., Free PMC Article | 12/17/2016 |
| results suggest that the down-regulation of morphine-dependent EAAT3 expression in primary hippocampal cultures may be mediated by micro opioid receptor and delta opioid receptor and that kappa opioid receptor may not contribute significantly to this effect | Chronic exposure to morphine decreases the expression of EAAT3 via opioid receptors in hippocampal neurons.
Guo M, Cao D, Zhu S, Fu G, Wu Q, Liang J, Cao M. | 10/1/2016 |
| Chronic postnatal stress led to decreased Eaat3 expression in hippocampus and frontal cortex. | Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats.
Odeon MM, Andreu M, Yamauchi L, Grosman M, Acosta GB. | 07/16/2016 |
| data indicate that NRG1 induced the up-regulation of EAAC1 in primary cortical neurons with an increase in glutamate uptake | Neuregulin 1 Controls Glutamate Uptake by Up-regulating Excitatory Amino Acid Carrier 1 (EAAC1).
Yu HN, Park WK, Nam KH, Song DY, Kim HS, Baik TK, Woo RS., Free PMC Article | 12/12/2015 |
| changes of phosphorylated GluR1 subunit of AMPAR protein level in the hippocampus and frontal cortex, as well as markedly decreased EAAT2 mRNA expression in the hippocampus, striatum and frontal cortex and EAAT3 mRNA expression in the hippocampus | Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress.
Zhang XH, Jia N, Zhao XY, Tang GK, Guan LX, Wang D, Sun HL, Li H, Zhu ZL. | 04/5/2014 |
| Nicotine decreases EAAT3 activity, and this inhibition seems to be dependent on PKC and PI3K. | Nicotine decreases the activity of glutamate transporter type 3.
Yoon HJ, Lim YJ, Zuo Z, Hur W, Do SH. | 03/8/2014 |
| Buffering and reuptake, but not presynaptic release, of glutamate is altered via Eaat3 in glutamate synapses in temporal lobe haloperidol-treated rat model of schizophrenia. | Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia.
Shan D, Lucas EK, Drummond JB, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE., Free PMC Article | 08/31/2013 |
| Spinal EAAC1 expression is significantly increased only in the nonpainful groups on day 7 following whiplash injury. | Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity.
Dong L, Quindlen JC, Lipschutz DE, Winkelstein BA., Free PMC Article | 04/6/2013 |
| Increased EAAT3 expression in the hippocampus may be a compensatory response to possible deficits of glutamatergic neurotransmission induced by methamphetamine. | Changes in the neuronal glutamate transporter EAAT3 in rat brain after exposure to methamphetamine.
Kerdsan W, Thanoi S, Nudmamud-Thanoi S. | 02/9/2013 |
| interaction of NCX1 and EAAC1 transporters leads to glutamate-enhanced ATP production in brain mitochondria | Physical and functional interaction of NCX1 and EAAC1 transporters leading to glutamate-enhanced ATP production in brain mitochondria.
Magi S, Lariccia V, Castaldo P, Arcangeli S, Nasti AA, Giordano A, Amoroso S., Free PMC Article | 11/17/2012 |
| EAAC1 mRNA localizes to dendrites via dendritic targeting of EAAC1 mRNA, which is increased by seizure activity and may be regulated by neuronal activity/depolarization. | mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizure.
Ross JR, Porter BE, Buckley PT, Eberwine JH, Robinson MB., Free PMC Article | 12/31/2011 |
| Following subarachnoid hemorrhage there is significant downregulation of EAAC1 glutamate transporter in cerebral cortex and hippocampus. | Temporal changes in glutamate, glutamate transporters, basilar arteries wall thickness, and neuronal variability in an experimental rat model of subarachnoid hemorrhage.
Wu CT, Wen LL, Wong CS, Tsai SY, Chan SM, Yeh CC, Borel CO, Cherng CH. | 04/23/2011 |
| EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2 and EAAT3 are capable of co-assembling into heterotrimers. Co-expression of EAAT3 and EAAT4 results in additional appearance of basolateral EAAT3 | Hetero-oligomerization of neuronal glutamate transporters.
Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C., Free PMC Article | 03/26/2011 |
| Existence of a pool of EAAC1 transporters associated with the actin binding protein alpha-adducin in a PKC-insensitive manner is suggested. | The glutamate transporter excitatory amino acid carrier 1 associates with the actin-binding protein alpha-adducin.
Bianchi MG, Gatti R, Torielli L, Padoani G, Gazzola GC, Bussolati O. | 11/27/2010 |
| Results indicate a transient decrease in EAAC1 glutamate transporter RNA expression in the rat hippocampus during the early stages of a spatial learning task. | Glutamate transporters are differentially expressed in the hippocampus during the early stages of one-day spatial learning task.
Fraticelli-Torres AI, Matos-Ocasio F, Thompson KJ., Free PMC Article | 08/16/2010 |
| analysis of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr10 | Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
Tao Z, Rosental N, Kanner BI, Gameiro A, Mwaura J, Grewer C., Free PMC Article | 06/28/2010 |
| Our findings reveal an adaptive response of subcortical white matter to increased levels of glutamate (by enhanced expression of EAAT1, 2 and 3) during focal cerebral ischemia which may limit excitotoxic damage. | Increased expression of glutamate transporters in subcortical white matter after transient focal cerebral ischemia.
Arranz AM, Gottlieb M, Pérez-Cerdá F, Matute C. | 03/1/2010 |
| Our results suggest a critical role of serine 465 in the increased EAAT3 activity by protein kinase C activation | Critical role of s465 in protein kinase C-increased rat glutamate transporter type 3 activity.
Baik HJ, Huang Y, Washington JM, Zuo Z., Free PMC Article | 02/1/2010 |
| Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3. | Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3.
Lee SA, Choi JG, Zuo Z., Free PMC Article | 01/21/2010 |
| Data show that EAAC1 is up-regulated in the hippocampal CA1 region and the motor cortex area in rats with global cerebral ischemia with epilepsy. | The expression of glutamate transporters in chest compression-induced audiogenic epilepsy: a comparative study.
Lu Z, Zhang W, Zhang N, Jiang J, Luo Q, Qiu Y. | 01/21/2010 |
| different regulatory pathways of EAAC1 are associated with different neuronal maturation stages | Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: evidence for different regulatory pathways associated with neuronal maturation.
Lortet S, Canolle B, Masmejean F, Nieoullon A. | 01/21/2010 |