| Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1. | Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1.
Chai Q, Meng Z, Lu D, Zhang Z, Liu M, Wu W. | 07/31/2021 |
| this study also aims to determine the active ingredients of H. sabdariffa (Hib) that interact with sodium-glucose cotransporter-1 (SGLT-1) so that it can increase GLP-1 secretion in the ileum and interact with GLP-1 receptors (GLP-1R) in the pancreas. | The Potential of Hibiscus sabdariffa Linn in Inducing Glucagon-Like Peptide-1 via SGLT-1 and GLPR in DM Rats.
Kartinah NT, Fadilah F, Ibrahim EI, Suryati Y., Free PMC Article | 04/25/2020 |
| SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation. | SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation.
Oliveira TL, Candeia-Medeiros N, Cavalcante-Araújo PM, Melo IS, Fávaro-Pípi E, Fátima LA, Rocha AA, Goulart LR, Machado UF, Campos RR, Sabino-Silva R., Free PMC Article | 12/24/2016 |
| CG was mainly transported into the small intestinal cells by sodium-dependent glucose transporter 1. | SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats.
Shi J, Zheng H, Yu J, Zhu L, Yan T, Wu P, Lu L, Wang Y, Hu M, Liu Z. | 10/29/2016 |
| Present study indicated that inhibition of SGLT1 by phlorizin abrogated the beneficial effect of ischemic-preconditioning and for the first time, provides evidence that SGLT1 plays a crucial role in ischemic preconditioning-induced cardioprotection. | Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury.
Kanwal A, Nizami HL, Mallapudi S, Putcha UK, Mohan GK, Banerjee SK. | 08/13/2016 |
| Elevated SGLT activity increases Na+ influx into myocytes and causes Na+ overload in type 2 diabetes. | Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.
Lambert R, Srodulski S, Peng X, Margulies KB, Despa F, Despa S., Free PMC Article | 06/11/2016 |
| Data indicate that there are several alternative channels for urea in the rat inner medulla that could potentially contribute to the high urea permeabilities in thin limb segments. | Alternative channels for urea in the inner medulla of the rat kidney.
Nawata CM, Dantzler WH, Pannabecker TL., Free PMC Article | 04/2/2016 |
| These findings suggest that SGLT1 in the ventromedial hypothalamus plays a significant role in the detection and activation of counterregulatory responses to hypoglycemia. | Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats.
Fan X, Chan O, Ding Y, Zhu W, Mastaitis J, Sherwin R., Free PMC Article | 01/16/2016 |
| glucose stimulates neurotensin secretion by uptake through SGLT1 and GLUT2, both causing depolarization either as a consequence of sodium-coupled uptake (SGLT1) or by closure of KATP channels (GLUT2 and SGLT1) secondary to the ATP-generating metabolism of glucose. | Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2, leading to cell depolarization and calcium influx.
Kuhre RE, Bechmann LE, Wewer Albrechtsen NJ, Hartmann B, Holst JJ. | 08/29/2015 |
| Chronic and direct silencing of basolateral Na-K-ATPase uniquely regulates brush border membrane Na absorptive pathways in intestinal epithelial cells. Specifically, SGLT1 is stimulated secondary to enhanced affinity of the cotransporter. | Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells.
Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick GM, Sundaram U., Free PMC Article | 07/25/2015 |
| SGLT1 or GLUT2 interact with the cytoskeleton in the intestinal epithelium during hexose absorption. | [The interaction between SGLT1 or GLUT2 glucose transporter and the cytoskeleton in the enterocyte as well as Caco2 cell during hexose absorption].
Grefner NM, Gromova LV, Gruzdkov AA, Komissarchik IaIu. | 03/21/2015 |
| Immunofluorescence experiments showed that NHE3 colocalizes with SGLT2 but not SGLT1 in the renal proximal tubule. | Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule.
Pessoa TD, Campos LC, Carraro-Lacroix L, Girardi AC, Malnic G., Free PMC Article | 11/22/2014 |
| Tunicamycin to inhibit glycosylation reduced SGLT1 activity. | Regulation of sodium glucose co-transporter SGLT1 through altered glycosylation in the intestinal epithelial cells.
Arthur S, Coon S, Kekuda R, Sundaram U. | 05/24/2014 |
| Lean and obese ZDF rats exhibited disruptions in circadian feeding. Glucose intolerance was evident in lean rats, but only obese rats developed diabetes and exhibited disrupted circadian rhythmicity of SGLT1 expression and function. | Disrupted circadian rhythmicity of the intestinal glucose transporter SGLT1 in Zucker diabetic fatty rats.
Bhutta HY, Deelman TE, Ashley SW, Rhoads DB, Tavakkoli A., Free PMC Article | 08/31/2013 |
| Data suggest that contribution of Sglt1 to renal glucose reabsorption is greater under hypoglycemia than under hyperglycemia; as hypoglycemic agents, Sglt1-selective inhibitors carry a greater risk of causing hypoglycemia than Sglt2 inhibitors. | Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats.
Nagata T, Fukazawa M, Honda K, Yata T, Kawai M, Yamane M, Murao N, Yamaguchi K, Kato M, Mitsui T, Suzuki Y, Ikeda S, Kawabe Y. | 04/6/2013 |
| down regulation of the expression of SGLT1 and brush border sucrase and lactase activities may be responsible for the observed malabsorption in G. lamblia infection | Expression of sodium-glucose co-transporter and brush border disaccharidases in Giardia lamblia infected rat intestine.
Mahmood S, Sodhi CP, Ganguly NK. | 09/22/2012 |
| High glucose induced cardiac myocyte p47phox translocation to the plasma membrane, resulting in SGLT1 dependent NOX2 activation. | NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
Balteau M, Tajeddine N, de Meester C, Ginion A, Des Rosiers C, Brady NR, Sommereyns C, Horman S, Vanoverschelde JL, Gailly P, Hue L, Bertrand L, Beauloye C. | 02/4/2012 |
| Hexose transporter-mediated glucose uptake was greater in duodenum and jejunum compared with ileum. | Coordinated, diurnal hexose transporter expression in rat small bowel: implications for small bowel resection.
Houghton SG, Iqbal CW, Duenes JA, Fatima J, Kasparek MS, Sarr MG., Free PMC Article | 12/6/2011 |
| SGLT1 and rosmarinic acid modulate the trafficking of SGLT1 to the brush-border membrane and may contribute to the control of plasma glucose. | Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose.
Azevedo MF, Lima CF, Fernandes-Ferreira M, Almeida MJ, Wilson JM, Pereira-Wilson C. | 08/6/2011 |
| Na/H exchange protein NHE3 and SGLT1 function together to regulate sodium absorption in the brush border membrane of intestinal epithelial cells. | Reciprocal regulation of the primary sodium absorptive pathways in rat intestinal epithelial cells.
Coon S, Kekuda R, Saha P, Sundaram U., Free PMC Article | 04/23/2011 |
| SGLT1 glucose uptake alleviated ischemia/reperfusion-induced barrier dysfunction and bacterial translocation, partly by inhibiting epithelial apoptosis via activation of PI3K/Akt signaling. | Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia.
Huang CY, Hsiao JK, Lu YZ, Lee TC, Yu LC. | 03/19/2011 |
| the present findings show that diabetic- and/or hypertensive-induced changes in the sympathetic activity correlate with changes in SGLT1 expression in basolateral membrane of acinar cells | SGLT1 protein expression in plasma membrane of acinar cells correlates with the sympathetic outflow to salivary glands in diabetic and hypertensive rats.
Sabino-Silva R, Alves-Wagner AB, Burgi K, Okamoto MM, Alves AS, Lima GA, Freitas HS, Antunes VR, Machado UF. | 01/1/2011 |
| SGLT1 appears to be also expressed in alveolar type I cells | Evidence for Na+-glucose cotransporter in type I alveolar epithelium.
Bodega F, Sironi C, Armilli M, Porta C, Agostoni E. | 12/4/2010 |
| Infusion of sweetening agents into the small intestine resulted in rapid upregulation of sodium-glucose transporter SGLT1 in the Sprague-Dawley rat. | Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation.
Stearns AT, Balakrishnan A, Rhoads DB, Tavakkolizadeh A., Free PMC Article | 05/31/2010 |
| Baseline regulation of hexose transporter (SGLT1, GLUT2, and GLUT5) function is not mediated tonically by intrinsic or extrinsic neural continuity to the jejunoileum. | Expression and function of intestinal hexose transporters after small intestinal denervation.
Iqbal CW, Fatima J, Duenes J, Houghton SG, Kasparek MS, Sarr MG., Free PMC Article | 01/21/2010 |