| Together with previous studies, these data support a model whereby Munc18-1 acts as a template for SNARE complex assembly, and autoinhibition of synaptobrevin binding contributes to enabling regulation of neurotransmitter release by Munc13-1. | Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J., Free PMC Article | 02/24/2018 |
| Our study uncovers the postsynaptic function of the SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE complex is involved in excitatory synaptic transmission | Identification of the SNARE complex mediating the exocytosis of NMDA receptors.
Gu Y, Huganir RL., Free PMC Article | 02/10/2018 |
| differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b | Indication for differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b.
Rodepeter FR, Wiegand S, Lüers HG, Bonaterra GA, Lowe AW, Bette M, Jacob R, Mandic R. | 10/7/2017 |
| TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion. | TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
Meng J, Wang J, Steinhoff M, Dolly JO., Free PMC Article | 12/24/2016 |
| residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates. | Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M., Free PMC Article | 11/7/2015 |
| syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes | Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli.
Meng J, Dolly JO, Wang J. | 09/12/2015 |
| distribution of SNAP25, VAMP1 and VAMP2 in adult deep cerebellar nuclei differs significantly from that found in newborn DCN and administration of E2 in the newborn DCN affected synaptic density and also changed their distribution | Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J. | 02/14/2015 |
| The results of this study provided the first evidence showing the dual role of SNAP25 and synaptobrevin in both exocytosis and slow endocytosis at conventional synapses. | The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses.
Zhang Z, Wang D, Sun T, Xu J, Chiang HC, Shin W, Wu LG., Free PMC Article | 08/10/2013 |
| multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion | Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation.
Williams AL, Bielopolski N, Meroz D, Lam AD, Passmore DR, Ben-Tal N, Ernst SA, Ashery U, Stuenkel EL., Free PMC Article | 07/2/2011 |
| Syntaxin-4 and VAMP-1 and VAMP-2 regulate cardiac myocyte exocytosis of ANP. | VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes.
Ferlito M, Fulton WB, Zauher MA, Marbán E, Steenbergen C, Lowenstein CJ., Free PMC Article | 01/22/2011 |
| the trigger site in synaptobrevin is crucial for productive SNARE zippering | A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex.
Wiederhold K, Kloepper TH, Walter AM, Stein A, Kienle N, Sørensen JB, Fasshauer D., Free PMC Article | 08/16/2010 |
| Data report the structure and the assembling behavior of VAMP1 incorporated in a lipid monolayer at an air-water interface which mimics the membrane environment, and show that the structure of VAMP1 is clearly controlled by protein-lipid interactions. | Effect of monolayer lipid charges on the structure and orientation of protein VAMP1 at the air-water interface.
Yassine W, Milochau A, Buchoux S, Lang J, Desbat B, Oda R. | 05/31/2010 |
| Several species of Vamp1 were amplified from a brain cDNA library including a full length clone of Vamp1as and a novel splice variant we termed Vamp1nv that was expressed in each of the cochlear nucleus subdivisions. | Identification of a novel Vamp1 splice variant in the cochlear nucleus.
Friedland DR, Eernisse R, Popper P., Free PMC Article | 01/21/2010 |
| CGRP was found to occur in the majority of neurons from rat trigeminal ganglia, together with the three exocytotic SNAREs [SNAP25, syntaxin 1 and the synaptobrevin (Sbr, also known as VAMP) isoforms] and synaptotagmin. | Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential.
Meng J, Wang J, Lawrence G, Dolly JO. | 01/21/2010 |
| Data show that synaptobrevin in proteoliposomes as well as in purified synaptic vesicles is constitutively active. | Determinants of synaptobrevin regulation in membranes.
Siddiqui TJ, Vites O, Stein A, Heintzmann R, Jahn R, Fasshauer D., Free PMC Article | 01/21/2010 |
| Treatment with botulinum neurotoxins A and B strongly reduced somatodendritic dopamine release, thus demonstrating the requirement for SNARE proteins SNAP-25 and synaptobrevin. | Basal somatodendritic dopamine release requires snare proteins.
Fortin GD, Desrosiers CC, Yamaguchi N, Trudeau LE. | 01/21/2010 |
| is the main isoform in particular brain areas (e.g. zona incerta at the subthalamus or nerve terminals surrounding thalamic neurons) | Distribution of synaptobrevin/VAMP 1 and 2 in rat brain.
Raptis A, Torrejón-Escribano B, Gómez de Aranda I, Blasi J. | 01/21/2010 |
| vesicle-associated membrane protein 1 is involved in secretion of polypeptides from the choroid plexus epithelium. | Expression of two membrane fusion proteins, synaptosome-associated protein of 25 kDa and vesicle-associated membrane protein, in choroid plexus epithelium.
Chung I, Burkart A, Szmydynger-Chodobska J, Dodd KA, Trimble WS, Miller KV, Shim M, Chodobski A. | 01/21/2010 |
| VAMP1 mRNA is transiently decreased during nerve regeneration of the facial motor nucleus after axotomy. | Changes in mRNA for VAMPs following facial nerve transection.
Che YH, Yamashita T, Tohyama M. | 01/21/2010 |